Article
Robotics
Chingyi Nam, Wei Rong, Waiming Li, Chingyee Cheung, Wingkit Ngai, Tszching Cheung, Mankit Pang, Li Li, Junyan Hu, Honwah Wai, Xiaoling Hu
Summary: This article presents a novel electromyography (EMG)-driven exoneuromusculoskeleton that integrates the neuromuscular electrical stimulation (NMES), soft pneumatic muscle, and exoskeleton techniques, for self-help upper limb training after stroke. The developed system provides significant improvement in limb performance and muscular coordination, supporting self-help upper limb rehabilitation after stroke.
Review
Physiology
Alexandre Foure, Julien Gondin
Summary: This review focuses on the functional, structural, and cellular consequences of electrically evoked submaximal isometric contractions that can lead to severe and localized skeletal muscle damage, as well as discussing hypotheses related to the underlying physiological and mechanical processes involved.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Article
Automation & Control Systems
Heber H. Arcolezi, Willian R. B. M. Nunes, Rafael A. de Araujo, Selene Cerna, Marcelo A. A. Sanches, Marcelo C. M. Teixeira, Aparecido A. de Carvalho
Summary: In this study, a novel, robust, and intelligent closed-loop NMES system control approach was introduced, utilizing robust control and machine learning tools to build realistic data-driven models using past rehabilitation data. The use of the RISE controller in rehabilitation showed improved control performance and avoided premature fatigue in NMES-based procedures.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2021)
Article
Chemistry, Multidisciplinary
Paula Ketilly Nascimento Alves, Joao G. Silvestre, Wenddy Wyllie Damascena Sougey, Andre Cruz, Anselmo Sigari Moriscot
Summary: Efficient and suitable animal models for skeletal muscle hypertrophy are needed. In this study, researchers developed an improved muscle training protocol by directly stimulating the tibialis anterior muscle in mice. The results showed that this strategy promoted quick and intense muscle hypertrophy.
APPLIED SCIENCES-BASEL
(2022)
Review
Physiology
Kelly R. Greve, Christopher F. Joseph, Blake E. Berry, Kornel Schadl, Jessica Rose
Summary: Neuromuscular Electrical Stimulation (NMES) shows potential in improving neuromuscular impairments and function in individuals with spastic cerebral palsy (CP). Studies have demonstrated that NMES-assisted strengthening, NMES-assisted gait, and NMES for spasticity reduction can enhance functional mobility and reduce spasticity in these individuals.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Thomas B. Inns, Daniel McCormick, Carolyn A. Greig, Philip J. Atherton, Bethan E. Phillips, Mathew Piasecki
Summary: This study compared NMES and PNS in terms of fatigue performance and peripheral contribution to voluntary force capacity. While both induced force reductions, NMES led to changes in myoelectrical activity suggesting performance fatigability, whereas PNS did not. This suggests PNS recruits a wider pool of muscle fibres and motor units, making it a favorable alternative for rehabilitation.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Edward J. Hardy, Jacob Hatt, Brett Doleman, Thomas F. Smart, Matthew Piasecki, Jonathan N. Lund, Bethan E. Phillips
Summary: Neuromuscular electrical stimulation (NMES) can reduce muscle atrophy and functional declines in older adults following major abdominal surgery, which may be a promising tool for post-operative recovery.
Article
Chemistry, Analytical
Kelly Greve, Caroline Colvin
Summary: This study demonstrates a novel approach of using neuromuscular electrical stimulation (NMES) in acute rehabilitation phase following orthopaedic surgery in children with CP. Results show that children experienced improvements in walking ability and most children showed progress in functional mobility and gross motor function.
Article
Orthopedics
Isabel de Almeida Paz, Graciane Taglian Rigo, Amanda Sgarioni, Bruno Manfredini Baroni, Viviane Bortoluzzi Frasson, Marco Aurelio Vaz
Summary: The study found that under submaximal contraction level, PC is more effective than AC in generating muscle fatigue, while there is no significant difference in discomfort level between the two.
Article
Multidisciplinary Sciences
Yuichiro Honda, Ayumi Takahashi, Natsumi Tanaka, Yasuhiro Kajiwara, Ryo Sasaki, Seima Okita, Junya Sakamoto, Minoru Okita
Summary: Muscle contractile exercise through a belt electrode device can effectively prevent immobilization-induced myofiber atrophy, muscle contracture, and muscular pain.
Article
Rehabilitation
Yiming Ma, Sonja de Groot, Ad Vink, Wouter Harmsen, Christof A. J. Smit, Janneke M. Stolwijk-Swuste, Peter J. M. Weijs, Thomas W. J. Janssen
Summary: This study aimed to evaluate the increase in energy expenditure using surface neuromuscular electrical stimulation (NMES) for paralyzed lower-limb muscles and whether the number of activated muscles and duty cycle affect the potential increase. The results showed that energy expenditure during all NMES protocols was significantly higher than without NMES, with the highest increase for the protocol with more muscles activated and the duty cycle with a shorter rest period.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Sport Sciences
Lasse Gliemann, Nicolai Rytter, Tue Smith Jorgensen, Peter Piil, Howard Carter, Michael Nyberg, Marcello Grassi, Martin Daumer, Ylva Hellsten
Summary: The study found that 2 weeks of leg immobilization significantly reduces angiogenesis potential, as evidenced by reduced muscle and platelet VEGF content, as well as a decreased muscle VEGF to thrombospondin-1 ratio. Despite undergoing 4 weeks of intense aerobic exercise training following immobilization, there was no increase in capillarization in the previously immobilized leg due to the angiostatic condition caused by immobilization.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Cell Biology
J. H. Lautaoja, D. C. Turner, A. P. Sharples, R. Kivela, S. Pekkala, J. J. Hulmi, L. Yla-Outinen
Summary: The number of studies using skeletal muscle cell culture models to study exercise in vitro is increasing rapidly. Omics approaches, such as transcriptomics, proteomics, and metabolomics, have been used to analyze the molecular responses to exercise mimicking stimuli in cultured myotubes. Electrical pulse stimulation and mechanical stretch are the most commonly used methods to mimic exercise in vitro. This mini-review provides an up-to-date overview of the 2-D and 3-D models and the use of omics approaches to study the molecular response to exercise in vitro.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Renato Fraga Righetti, Samantha Torres Grams, Wesla Neves da Silva Costa, Leandro Teixeira Saraiva, Isabel Chateaubriand Diniz de Salles, Wellington Pereira Yamaguti
Summary: Rehabilitation with NMES showed improvement in muscle strength and functionality in patients with severe COVID-19 associated with sepsis and septic shock, with a potential protective effect on muscle mass loss.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Elisabeth A. Kilroy, Amanda C. Ignacz, Kaylee L. Brann, Claire E. Schaffer, Devon Varney, Sarah S. Alrowaished, Kodey J. Silknitter, Jordan N. Miner, Ahmed Almaghasilah, Tashawna L. Spellen, Alexandra D. Lewis, Karissa Tilbury, Benjamin L. King, Joshua B. Kelley, Clarissa A. Henry
Summary: Neuromuscular electrical stimulation has the potential to promote muscle homeostasis in patients with muscle disease, with endurance neuromuscular stimulation showing the best improvement in muscle health.
Article
Biochemistry & Molecular Biology
Pieter A. Leermakers, Alexander H. V. Remels, Marijke I. Zonneveld, Kasper M. A. Rouschop, Annemie M. W. J. Schols, Harry R. Gosker
Article
Biochemistry & Molecular Biology
Wessel F. Theeuwes, Nicholas A. M. Pansters, Harry R. Gosker, Annemie M. W. J. Schols, Koen J. P. Verhees, Chiel C. de Theije, Rick H. P. van Gorp, Marco C. J. M. Kelders, Onne Ronda, Astrid Haegens, Alexander H. Remels, Ramon C. J. Langen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Nutrition & Dietetics
Martijn van Beers, Harry R. Gosker, Daisy J. A. Janssen, Fiona A. H. M. Cleutjens, Frits M. E. Franssen, Martin P. J. van Boxtel, Emiel F. Wouters, Rudolf W. H. M. Ponds, Annemie M. W. J. Schols
Summary: The study found that cognitive performance was not significantly more impaired in COPD patients with sarcopenia or MetS compared to those without. Domain-specific cognitive performance was not different between metabolic subgroups, although those with sarcopenia had a lower prevalence of cognitive impairment in verbal memory compared to those without. Only the digit span subtest showed significant difference between metabolic subgroups, in favor of those without MetS.
CLINICAL NUTRITION
(2021)
Review
Respiratory System
Sophie I. J. van Bakel, Harry R. Gosker, Ramon C. Langen, Annemie M. W. J. Schols
Summary: Awareness of sarcopenia has increased over the past decade, with COPD patients having a higher prevalence of the condition. In addition to physical inactivity, COPD-specific physiological changes contribute to the accelerated development of sarcopenia. Treatment of muscle impairment through exercise training and protein supplementation can halt or even reverse sarcopenia, despite respiratory limitations. There are current and new interventions targeting the pulmonary system that may also help maintain muscle mass in COPD patients.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Review
Nutrition & Dietetics
Lieke E. J. van Iersel, Rosanne J. H. C. G. Beijers, Harry R. Gosker, Annemie M. W. J. Schols
Summary: This systematic review examines the association between dietary intake and nutrient status with the risk and onset of COPD, as well as pulmonary function decline in patients with COPD. The unhealthy Western-style diet is associated with an increased risk of COPD and accelerated decline of pulmonary function. On the other hand, the intake of certain fruits, vegetables, dietary fibers, vitamins, polyphenols, and beta-carotene is associated with a lower risk of COPD.
Article
Environmental Sciences
Jeannet M. Delbressine, Felipe V. C. Machado, Yvonne M. J. Goertz, Maarten Van Herck, Roy Meys, Sarah Houben-Wilke, Chris Burtin, Frits M. E. Franssen, Yvonne Spies, Herman Vijlbrief, Alex J. van 't Hul, Daisy J. A. Janssen, Martijn A. Spruit, Anouk W. Vaes
Summary: Patients with persistent symptoms after COVID-19 may still demonstrate a significantly decreased walking time six months after symptom onset. Further research is needed to investigate long-term consequences and potential treatment options to guide patients during recovery from COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Pediatrics
Alina Ofenheimer, Robab Breyer-Kohansal, Sylvia Hartl, Otto C. Burghuber, Florian Krach, Frits M. E. Franssen, Emiel F. M. Wouters, Marie-Kathrin Breyer
Summary: The study investigated serum lipid profiles and other characteristics in relation to body composition in children. Results showed that children with high ALMI and high FMI had higher triglycerides and LDL-c levels, but lower HDL-c levels. Differences were not observed between children with high FMI but low (or normal) ALMI, and other body composition groups. This emphasizes the importance of measuring body composition with more precise techniques rather than relying solely on BMI.
Article
Medicine, General & Internal
Rosanne J. H. C. G. Beijers, Lieke E. J. van Iersel, Lisanne T. Schuurman, Robert J. J. Hageman, Sami O. Simons, Ardy van Helvoort, Harry R. Gosker, Annemie M. W. J. Schols
Summary: This study aims to investigate the effectiveness of targeted nutrient supplementation on physical activity level and health-related quality of life in COPD patients. Cognitive function, psychological well-being, physical performance, and other outcomes will also be assessed. The study will provide valuable insights into the impact of nutrient supplementation on COPD patients and may have implications for treatment strategies.
Article
Cell Biology
Lei Wang, Lieke E. J. van Iersel, Charlotte E. Pelgrim, Jingyi Lu, Ingrid van Ark, Thea Leusink-Muis, Harry R. Gosker, Ramon C. J. Langen, Annemie M. W. J. Schols, Josep M. Argiles, Ardy van Helvoort, Aletta D. Kraneveld, Johan Garssen, Paul A. J. Henricks, Gert Folkerts, Saskia Braber
Summary: This study investigates the effects of smoking-induced chronic obstructive pulmonary disease (COPD) on adipose and skeletal muscle tissue. The results show that smoking-induced lung disease affects whole-body fat mass and adipose atrophy, which may be due to enhanced lipolysis.
Review
Medicine, General & Internal
Ianthe Piscaer, Rob Janssen, Frits M. E. Franssen, Leon J. Schurgers, Emiel F. M. Wouters
Summary: Patients with chronic obstructive pulmonary disease (COPD) often have multiple co-occurring conditions and systemic manifestations. Vitamin A, vitamin D, and vitamin K are all potentially involved in COPD pathogenesis. In this review, the potential role of vitamin K in the systemic manifestations of COPD is discussed, including its effects on prevalent co-occurring chronic conditions such as cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Recommendations for future clinical studies are also provided.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Charlotte E. E. Pelgrim, Ingrid van Ark, Ronja E. E. van Berkum, Anne M. M. Schuitemaker-Borneman, Inge Flier, Thea Leusink-Muis, Hamed Janbazacyabar, Mara A. P. Diks, Harry R. R. Gosker, Marco C. J. M. Kelders, Ramon C. J. Langen, Annemie M. W. J. Schols, Robert J. J. Hageman, Saskia Braber, Johan Garssen, Gert Folkerts, Ardy van Helvoort, Aletta D. D. Kraneveld
Summary: Extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD), including anxiety, depression, and cognitive impairment, can impact brain function and worsen symptoms. This study used a mouse model to examine the effects of emphysema and pulmonary inflammation on systemic inflammation and brain function in COPD. A dietary intervention enriched with specific nutrients improved cognitive impairments and reduced anxiety-like behavior.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Yuqin Zeng, Martijn A. Spruit, Qichen Deng, Frits M. E. Franssen, Ping Chen
Summary: This study aimed to measure the differences between male and female patients with COPD in terms of risk factors, symptoms, quality of life, and drug prescriptions. The results showed that female patients with COPD had lower educational levels and were less likely to be married. Compared to male patients, female patients had more complaints of cough, breathlessness, decreased activity, decreased confidence, sleep problems, and lack of energy. In addition, more women were prescribed triple therapy.
Article
Critical Care Medicine
Sophie I. J. van Bakel, Hester A. Gietema, Patricia M. Stassen, Harry R. Gosker, Debbie Gach, Joop P. van den Bergh, Frits H. M. van Osch, Annemie M. W. J. Schols, Rosanne J. H. C. G. Beijers
Summary: This study found that CT scan-derived low pectoralis muscle CSA is significantly associated with higher 30-day in-hospital mortality in patients with COVID-19 independently of the 4C Mortality Score.
Article
Respiratory System
Martijn van Beers, Sarah W. Mount, Katrijn Houben, Harry R. Gosker, Lisanne Schuurman, Frits M. E. Franssen, Daisy J. A. Janssen, Annemie M. W. J. Schols
Summary: Working memory training in patients with COPD can improve performance on trained tasks, but does not significantly impact overall cognitive performance, healthy lifestyle behaviors, or cognitive stress susceptibility.
Review
Respiratory System
Harry R. Gosker, Ramon C. Langen, Sami O. Simons
Summary: This report reviews the impact of AECOPD on muscle dysfunction in COPD, highlighting the negative effects of AECOPD on muscle function and its underlying mechanisms. Novel treatment options should focus on the enhanced drivers of muscle dysfunction during AECOPD.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)