Article
Biochemistry & Molecular Biology
Ivan J. Vechetti, Bailey D. Peck, Yuan Wen, R. Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. McCarthy
Summary: Regular physical activity may improve health by releasing factors from skeletal muscle through extracellular vesicles (EVs) containing miR-1, promoting adipose tissue metabolic adaptations. EVs are preferentially taken up by eWAT, enhancing adrenergic signaling and lipolysis, ultimately benefiting overall health.
Article
Biochemistry & Molecular Biology
Robert H. Mak, Sujana Gunta, Eduardo A. Oliveira, Wai W. Cheung
Summary: Cachexia associated with chronic kidney disease (CKD) is linked to growth hormone (GH) resistance. This study found that GH treatment improved metabolism, food intake, weight growth, and muscular function in CKD mice. GH also decreased lipolysis, reversed adipose tissue browning, and normalized molecular markers of muscle wasting. Additionally, GH restored aberrant expression of muscle genes associated with thermogenesis, fibrosis, and regeneration. These findings suggest that GH may be an effective treatment for CKD-related cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jonathan C. Kershaw, Bennett D. Elzey, Xiao-Xuan Guo, Kee-Hong Kim
Summary: This study investigates the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. The results show that piceatannol can reduce cancer-associated lipolysis and preserve adipose tissue, protecting tumor-bearing mice against weight loss in the early stages of cancer-associated cachexia.
Review
Biochemistry & Molecular Biology
Steffen H. Raun, Kristian Buch-Larsen, Peter Schwarz, Lykke Sylow
Summary: Metabolic dysfunction is a common comorbidity of many types of cancers, and exercise may have a positive impact on correcting this condition. However, there is limited research on the effects of exercise on cancer-associated metabolic disruption, highlighting the need for further investigation. Future studies should aim to clarify how exercise can correct metabolic dysfunction in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xuan Ma, Jinzhao Zhang, Shengyu Wang, Yaming Li, Ibrahim Abdel Aziz Ibrahim, Xin Diao
Summary: In this study, the ameliorative effect of paclobutrazol against chronic cigarette smoke-induced COPD in rats was assessed. Results showed that paclobutrazol increased body weight, improved respiratory function, and decreased inflammation in rats exposed to secondhand smoke.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Cell Biology
Michele Ferrara, Maria Samaden, Elena Ruggieri, Emilie Venereau
Summary: Cachexia is a devastating syndrome associated with various end-stage diseases, such as cancer, causing weight loss, muscle wasting, and adipose tissue wasting. Despite its high prevalence and impact on patients' quality of life and prognosis, there is currently no effective therapy available. This review focuses on the multiple tissues affected by cachexia and the potential biomarkers for early identification of patients at risk.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Binglin Yue, Hui Wang, Xin Cai, Jiabo Wang, Zhixin Chai, Wei Peng, Shi Shu, Changqi Fu, Jincheng Zhong
Summary: Adipose tissue-secreted exosomes play a significant role in the intercellular communication between organs, especially with skeletal muscle. These exosomes transfer various molecules that can affect the physiological and pathological processes in recipient cells. Therefore, studying the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle is of great importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Bahar Zehra Camurdanoglu Weber, Dilsad H. Arabaci, Serkan Kir
Summary: Cancer cachexia is a disorder characterized by wasting of adipose tissue and skeletal muscle, leading to severe weight loss. There is a limited range of treatment options available for this condition. Changes in metabolic pathways in adipose tissue are associated with cancer cachexia. The energy-wasting circuits in adipose tissue impact whole-body metabolism, particularly skeletal muscle. Targeting key molecular players involved in metabolic reprogramming may help in developing new treatment strategies for cancer cachexia.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Mit Joshi, Bhoomika M. Patel
Summary: Cancer cachexia is a complex metabolic syndrome characterized by weight loss, anorexia, and emaciation. Research has shown that lipid metabolism plays a significant role in cancer cachexia, with tumors and host factors causing metabolic changes in the body.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Takayuki Yamamoto, Kazushi Sugimoto, Syuhei Ichikawa, Kei Suzuki, Hideki Wakabayashi, Kaoru Dohi, Norihiko Yamamoto
Summary: This study investigated the relationship between body composition and the prognosis of COVID-19. The results showed that high intra-muscular adipose tissue content (IMAC) may predict the severe disease course of COVID-19 in non-obese Japanese patients, but it did not predict disease severity in obese patients or mortality.
Correction
Medicine, Research & Experimental
Bimit Mahat, Etienne Chasse, Jean-Francois Mauger, Pascal Imbeault
Summary: The amended version has been published and can be accessed through the original article.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Stephen T. Decker, Oh-Sung Kwon, Jia Zhao, John R. Hoidal, Thomas Heuckstadt, Russell S. Richardson, Karl A. Sanders, Gwenael Layec
Summary: This study found that sedentary mice exposed to cigarette smoke for 8 months showed preserved mitochondrial respiratory capacity in skeletal muscle, but also increased risk of chronic oxidative stress.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Jing Xiong, Yanqing Le, Yafei Rao, Lu Zhou, Yuhan Hu, Suliang Guo, Yongchang Sun
Summary: The RANKL/RANK pathway plays an important role in muscle atrophy induced by COPD-related lung diseases, suggesting that it may be a potential therapeutic target for COPD-related skeletal muscle dysfunction.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Stephen T. Decker, Alexs A. Matias, Adolfo E. Cuadra, Sean T. Bannon, Jack P. Madden, M. Enes Erol, Corinna Serviente, Karine Fenelon, Gwenael Layec
Summary: Cigarette smoke exposure has acute dose-dependent toxicity on mitochondrial metabolism in different tissues, with the cardiac muscle being the most susceptible and the aorta being the least susceptible to cigarette smoke inhibition. This study provides insights into the mechanisms mediating the toxicity of cigarette smoke in extrapulmonary tissues.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Alessio Molfino, Giovanni Imbimbo, Maurizio Muscaritoli
Summary: The article describes the changes occurring in adipose tissue during cachexia, with a specific focus on cancer patients. It discusses the presence of inflammatory infiltration, enhanced fibrosis, beige adipocyte formation, and increased lipolysis. These changes in adiposity are associated with metabolic alterations, insulin resistance, and inflammation, ultimately leading to extreme and progressive unintentional weight loss.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Pharmacology & Pharmacy
Amir Hossein Alizadeh Bahmani, Elise M. A. Slob, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Simone Hashimoto, Anna M. Hedman, Michael Kabesch, Gerard H. Koppelman, Javier Korta-Murua, Aletta D. Kraneveld, Anne H. Neerincx, Marielle W. Pijnenburg, Maria Pino-Yanes, Uros Potocnik, Olaia Sardon-Prado, Susanne J. H. Vijverberg, Christine Wolff, Mahmoud Abdel-Aziz, Anke H. Maitland-van der Zee
Summary: This multicountry, observational, case-control study aimed to compare treatment regimens, inhaler techniques, medication adherence, and other characteristics of controlled and uncontrolled pediatric asthma. The study found that children in higher treatment steps had a higher risk of uncontrolled asthma, and the risk was also associated with a larger change in lung function post and pre-salbutamol. However, adherence and inhaler techniques were not related to the risk of uncontrolled asthma. Other factors, such as environmental factors and biological profiles, may influence the risk of uncontrolled asthma in this population.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Puqiao Lian, Paul A. J. Henricks, Harry J. Wichers, Gert Folkerts, Saskia Braber
Summary: This study evaluated the effects of nine nutritional components on heat/hypoxia-induced epithelial injury and found that several components, including non-digestible oligosaccharides, antioxidants, amino acids, and polyunsaturated fatty acids, showed protective effects on epithelial damage. These components improved epithelial integrity by increasing trans-epithelial electrical resistance, reducing paracellular permeability, and maintaining tight junction protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Luping Yuan, Jochen Springer, Sandra Palus, Silvia Busquets, Queralt Jove, Edson Alves de Lima Junior, Markus S. Anker, Stephan von Haehling, Natalia Alvarez Ladron, Oliver Millman, Annemijn Oosterlee, Agata Szymczyk, Francisco Javier Lopez-Soriano, Stefan D. Anker, Andrew J. S. Coats, Josep M. Argiles
Summary: Stereoisomers of oxprenolol, especially S-oxprenolol, have shown effectiveness in preclinical models of cancer cachexia. S-oxprenolol was superior to R-oxprenolol in terms of survival and weight loss reduction in the animal models tested. It also improved muscle function and had potential for human application in cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Yvonne Grobben, Judith E. den Ouden, Cristina Aguado, Anne M. van Altena, Aletta D. Kraneveld, Guido J. R. Zaman
Summary: Ovarian cancer, particularly high-grade serous ovarian cancer, has a highly immunosuppressive tumor microenvironment, which limits the effectiveness of immunotherapy. This study aimed to evaluate the role of amino acid-metabolizing enzymes in this environment by analyzing the levels of amino acids and corresponding metabolites in liquid biopsies of ovarian cancer patients. The enzymes IDO1 and IL4I1 were identified as active players, and a correlation between IL4I1 metabolite levels and disease stage was revealed. Further research on IL4I1 activity in ovarian cancer is needed to develop new immunotherapeutic strategies.
Article
Biochemistry & Molecular Biology
Marit Zuurveld, Veronica Ayechu-Muruzabal, Gert Folkerts, Johan Garssen, Belinda Van't Land, Linette E. M. Willemsen
Summary: Proper early-life immune development is crucial for a healthy immune system. Human milk oligosaccharides (HMOS) have immunomodulatory properties that are essential for neonatal immune maturation. In this study, five HMOS present in human milk were studied for their effects on the immune system. The results showed that 2'FL and 3FL had the most pronounced immunomodulatory effects, enhancing the secretion of key immune mediators.
Review
Critical Care Medicine
Lei Wang, Yang Cai, Johan Garssen, Paul A. J. Henricks, Gert Folkerts, Saskia Braber
Summary: Epidemiological studies show that COPD is linked to changes in intestinal health. Cigarette smoking, a major cause of COPD, affects the gastrointestinal system and promotes intestinal diseases. Gut-lung interactions occur through circulating inflammatory cells and mediators. Gut microbiota dysbiosis, systemic hypoxia, and oxidative stress play a role in the gut-lung axis. This review summarizes the possible mechanisms of gut-lung interactions in COPD and highlights potential therapies for intestinal dysfunction.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Neurosciences
Yuanpeng Zheng, Naika Prince, Christine van Hattem, Johan Garssen, Paula Perez Pardo, Aletta D. Kraneveld
Summary: This study investigated the relation between intestinal bacteria-associated para-cresyl sulfate (pCS) and 4-ethylphenyl sulfate (4EPS) and PTEN in autism spectrum disorder (ASD). It found that pCS and 4EPS can induce ASD-like behavior in mice, but the molecular mechanisms are not known.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Allergy
Jelle M. Blankestijn, Alejandro Lopez-Rincon, Anne H. Neerincx, Susanne J. H. Vijverberg, Simone Hashimoto, Mario Gorenjak, Olaia Sardon Prado, Paula Corcuera-Elosegui, Javier Korta-Murua, Maria Pino-Yanes, Uros Potocnik, Corinna Bang, Andre Franke, Christine Wolff, Susanne Brandstetter, Antoaneta A. Toncheva, Parastoo Kheiroddin, Susanne Harner, Michael Kabesch, Aletta D. Kraneveld, Mahmoud Abdel-Aziz, Anke H. Maitland-van der Zee
Summary: This study aimed to investigate whether the gastrointestinal microbiome can differentiate between uncontrolled and controlled asthma in children. By analyzing samples from 143 children with moderate-to-severe asthma, it was found that machine learning, specifically REFS, can differentiate the control level of asthma in children. The results suggest that the gastrointestinal microbiome may be a potential biomarker for treatment responsiveness and help improve asthma control in children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Maarten F. J. Seesing, Henricus J. B. Janssen, Tessa C. M. Geraedts, Teus J. Weijs, Ingrid van Ark, Thea Leusink-Muis, Gert Folkerts, Johan Garssen, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Richard van Hillegersberg, Misha D. P. Luyer
Summary: During esophagectomy, transecting the vagus nerve can lead to postoperative complications. The vagus nerve is involved in inflammation regulation and can be activated by high-fat nutrition, which releases acetylcholine that binds to a7 nicotinic acetylcholine receptors. This study investigates the impact of the vagus nerve and high-fat nutrition on LPS-induced lung injury in rats.
Article
Nutrition & Dietetics
Laura Saez-Fuertes, Ignasi Azagra-Boronat, Malen Massot-Cladera, Karen Knipping, Johan Garssen, Angels Franch, Margarida Castell, Francisco J. Perez-Cano, Maria J. Rodriguez-Lagunas
Summary: This study investigated the changes in intestinal gene expression after rotavirus infection and the effect of 2'-FL. The results showed that rotavirus infection upregulated host antiviral genes and downregulated genes involved in absorptive processes and intestinal maturation. Supplementation of 2'-FL reduced diarrhea symptoms caused by rotavirus infection, but had a similar effect on gene expression as in the control-infected group.
Editorial Material
Medicine, General & Internal
Joris C. Verster, Pauline A. Hendriksen, Pantea Kiani, Agnese Merlo, Jessica Balikji, Johan Garssen, Gillian Bruce
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jessica Balikji, Anna H. Koyun, Pauline A. Hendriksen, Pantea Kiani, Ann-Kathrin Stock, Johan Garssen, Maarten M. Hoogbergen, Joris C. Verster
Summary: Previous studies in Dutch young adults showed that individuals with self-reported impaired wound healing had poorer mood, attention, quality of life, and immune fitness. Another study revealed that the negative impact of lockdowns during the COVID-19 pandemic was more profound among the impaired wound healing group. This study aimed to replicate and extend these findings among young adults in Germany, and the results showed that individuals with impaired wound healing had significantly poorer mood, attention, quality of life, and immune fitness, with a greater impact during lockdowns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Hengjing Cui, Joshua D. Elford, Okko Alitalo, Paula Perez-Pardo, Janne Tampio, Kristiina M. Huttunen, Aletta Kraneveld, Markus M. Forsberg, Timo T. Myohanen, Aaro J. Jalkanen
Summary: Increasing evidence suggests that the gut-brain axis plays a crucial role in Parkinson's disease (PD), and 6-OHDA-induced nigrostriatal dopaminergic damage leads to increased α-synuclein (aSyn) levels and glial cell activation, particularly in the colon. This indicates that the gut-brain axis interactions in PD are bidirectional, and the detrimental process may start in the brain.
NEUROBIOLOGY OF AGING
(2023)
Article
Multidisciplinary Sciences
Carmina Angelica Perez-Romero, Lucero Mendoza-Maldonado, Alberto Tonda, Etienne Coz, Patrick Tabeling, Jessica Vanhomwegen, John MacSharry, Joanna Szafran, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Eric Claassen, Johan Garssen, Aletta D. Kraneveld, Alejandro Lopez-Rincon
Summary: As the COVID-19 pandemic calms down, there is growing concern about the possibility of future pandemics. The ability to quickly and accurately detect virus variants is crucial in mitigating the spread. Using an automated pipeline based on evolutionary algorithms, researchers have developed highly specific molecular tests for the main SARS-CoV-2 lineage and its variants. Preliminary validation shows promising results.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Marlou Mackus, Aurora J. A. E. van de Loo, Renier H. P. van Neer, Sterre A. Vermeulen, Chantal Terpstra, Karel A. Brookhuis, Johan Garssen, Andrew Scholey, Joris C. Verster
Summary: The alcohol hangover refers to the combination of negative mental and physical symptoms experienced after alcohol consumption. This study compared the next-day effects of alcohol consumption between hangover-resistant and hangover-sensitive drinkers, finding that hangover-sensitive drinkers experienced symptoms such as sleepiness, fatigue, concentration problems, and headache that gradually decreased throughout the day. Hangover-resistant drinkers, however, reported the absence of a hangover, except for increased fatigue and reduced vigor. The study highlights the differences in next-day effects between individuals who are more or less susceptible to alcohol hangovers.
JOURNAL OF CLINICAL MEDICINE
(2023)