Epigenetic Induction of EGR-1 Expression by the Amyloid Precursor Protein during Exposure to Novelty

Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer’s disease: implications for axoplasmic transport

(2011) Marina Morel et al.   ACTA NEUROPATHOLOGICA

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling

(2011) Xuan Xu et al.   EMBO REPORTS

The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells

(2011) Yue Hong et al.   INTERNATIONAL JOURNAL OF CANCER

Early Growth Response 1 (Egr-1) Regulates Phosphorylation of Microtubule-associated Protein Tau in Mammalian Brain

(2011) Yifan Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus

(2011) Konstantinos Sarantis et al.   NEUROCHEMISTRY INTERNATIONAL

Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor Protein α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway

(2011) Stéphanie Chasseigneaux et al.   PLoS One

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdala

(2010) S. A. Maddox et al.   LEARNING & MEMORY

Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease

(2010) Martín Gómez Ravetti et al.   PLoS One

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

(2009) Sandra Huysseune et al.   FASEB JOURNAL

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

(2009) Z. V. Goodger et al.   JOURNAL OF CELL SCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

(2008) Nikolai D Belyaev et al.   EMBO REPORTS

Memory reconsolidation mediates the strengthening of memories by additional learning

(2008) Jonathan L C Lee   NATURE NEUROSCIENCE

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

(2003) H. F. Dovey et al.   JOURNAL OF NEUROCHEMISTRY