Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines

Human AP endonuclease/redox factor APE1/ref-1modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1

(2012) Mengxia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

(2012) Lisa Lirussi et al.   MOLECULAR BIOLOGY OF THE CELL

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

(2012) Angelo A. Cardoso et al.   PLoS One

NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1

(2011) Brittney A. Manvilla et al.   BIOCHEMISTRY

In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease

(2011) N. C. Chavez-Tapia et al.   CURRENT MEDICINAL CHEMISTRY

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

(2011) Carlo Vascotto et al.   MOLECULAR BIOLOGY OF THE CELL

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

(2011) M. L. Fishel et al.   MOLECULAR CANCER THERAPEUTICS

APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1

(2011) Mark R. Kelley et al.   Current Molecular Pharmacology

Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1

(2010) Mark R. Kelley et al.   ANTIOXIDANTS & REDOX SIGNALING

Interactions of Apurinic/Apyrimidinic Endonuclease with a Redox Inhibitor: Evidence for an Alternate Conformation of the Enzyme

(2010) Dian Su et al.   BIOCHEMISTRY

Targeting DNA repair proteins for cancer treatment

(2010) Gianluca Tell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

(2010) Gianluca Tell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis

(2010) Melissa L. Fishel et al.   EXPERIMENTAL HEMATOLOGY

Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

(2010) A. Bapat et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tumor necrosis factor (TNF)-α-induced IL-8 expression in gastric epithelial cells: Role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1

(2009) Ann M. O’Hara et al.   CYTOKINE

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

(2009) Yanlin Jiang et al.   DNA REPAIR

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

(2009) Carlo Vascotto et al.   PROTEOMICS

Going Ape as an Approach to Cancer Therapeutics

(2008) Aditi Bapat et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein

(2008) Kishor K. Bhakat et al.   ANTIOXIDANTS & REDOX SIGNALING

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

(2008) G.-M. Zou et al.   MOLECULAR CANCER THERAPEUTICS

Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone

(2008) Daniel J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis

(2008) Fabio Marra et al.   TRENDS IN MOLECULAR MEDICINE