Article
Biochemistry & Molecular Biology
Ornella Selmin, Andreas J. Papoutsis, Sabine Hazan, Christopher Smith, Nick Greenfield, Micah G. Donovan, Spencer N. Wren, Thomas C. Doetschman, Justin M. Snider, Ashley J. Snider, Sherry H-H Chow, Donato F. Romagnolo
Summary: This study compared the effects of a typical Western diet and a soybean oil-rich n-6HFD on gut inflammation and microbiome using a mouse model. The results showed that n-6HFD induced colonic inflammation and altered gut bacterial composition, promoting the growth of proinflammatory bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fahimeh Zamani-Garmsiri, Seyyed Mohammad Reza Hashemnia, Maryam Shabani, Molood Bagherieh, Solaleh Emamgholipour, Reza Meshkani
Summary: The combination therapy of MET and GEN showed significant benefits against NAFLD in HFD-fed mice, reducing body weight, liver weight, fasting blood glucose levels, liver triglyceride levels, and inflammation while regulating key genes and pathways related to lipid metabolism, glucose production, and inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren
Summary: This study discovered that cysteine sulfinic acid decarboxylase (CSAD) expression significantly decreased in non-alcoholic fatty liver disease (NAFLD) patients, which was confirmed in multiple NAFLD mouse models. The overexpression of CSAD in the liver of high-fat diet-fed mice alleviated NAFLD-associated pathologies and increased the expression of fatty acid beta-oxidation genes. CSAD was also found to improve mitochondrial injury. These findings suggest that CSAD has the potential to become a new therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Liuyi Zheng, Guangyao Lin, Ruyue Li, Haining Gan, Xuejun Huang, Nan Yao, Dake Cai, Ziming Zhao, Zixuan Hu, Minyi Li, Huazhen Xu, Leyi Li, Sha Peng, Xinxin Zhao, Yijing Lai, Yuxing Chen, Dane Huang
Summary: ICAC promotes reverse cholesterol transport (RCT) and lowers lipid levels in both serum and liver without causing liver steatosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jinxin Liu, Yu Wang, Lamei Xue, Chenzhipeng Nie, Juan Sun, Mingcong Fan, Haifeng Qian, Li Wang, Yan Li
Summary: A whole-grain diet can reduce the risk of hypercholesterolemia by regulating bile acid metabolism and lowering cholesterol levels through various pathways to improve metabolic diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
An T. Nguyen, Sami A. Althwab, Haowen Qiu, Richard Zbasnik, Carlos Urrea, Timothy P. Carr, Vicki Schlegel
Summary: This study found that consumption of whole Great Northern beans can lower cholesterol concentration in male hamsters fed a high-saturated-fat diet by promoting fecal cholesterol excretion. The hull of the beans may partially contribute to the cholesterol-lowering effect.
JOURNAL OF NUTRITION
(2022)
Article
Agronomy
Tasneem S. Abu Ghazal, Hadil S. Subih, Belal S. Obeidat, Mofleh S. Awawdeh
Summary: The prevalence of obesity is increasing worldwide and is associated with alterations in health biomarkers. Consuming a 2.5:1 ratio of omega-6 and omega-3 helps restore standard health biomarkers. Hemp seed oil (HSO), with its favorable omega-6:omega-3 ratio, is a promising functional food for mitigating obesity-related injuries.
Article
Nutrition & Dietetics
Adam Lepczynski, Malgorzata Ozgo, Katarzyna Michalek, Alicja Dratwa-Chalupnik, Marta Grabowska, Agnieszka Herosimczyk, Kamila P. Liput, Ewa Polawska, Andrzej Kram, Mariusz Pierzchala
Summary: The study found that different high-fat diets had an impact on the structure and protein expression of the murine heart, with SFA-rich diets leading to severe cardiac hypertrophy and fibrosis, while diets rich in n-3 PUFA resulted in less pronounced changes.
Article
Nutrition & Dietetics
Xiaohua Huang, Yong Zhuo, Dandan Jiang, Yingguo Zhu, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Lun Hua, Yuanfeng Zou, Chao Huang, Lixia Li, De Wu, Bin Feng
Summary: Maternal low-protein diet during puberty and adulthood may disrupt metabolic gene expression in the liver of offspring and exacerbate insulin resistance and hepatic steatosis in offspring fed a high-fat diet.
Article
Nutrition & Dietetics
Zhitian Lu, Xudong Li, Min Wang, Xiaojun Zhang, Runxuan Zhuang, Fan Wu, Wenxue Li, Wei Zhu, Bo Zhang
Summary: Nobiletin (NOB), a compound found in citrus peels, has potential lipid-lowering and circadian-enhancing properties. This study showed that NOB can reduce liver triglyceride levels and regulate genes involved in lipid and cholesterol metabolism, independently of the core clock component Bmal1.
Article
Nutrition & Dietetics
Victoria Svop Jensen, Christian Fledelius, Erik Max Wulff, Jens Lykkesfeldt, Henning Hvid
Summary: The study demonstrates that hamsters rapidly develop dyslipidemia when fed a high-fat, high-fructose, high-cholesterol diet, and exhibit hepatic changes resembling human NAFLD within four to eight months on the NASH diet.
Article
Plant Sciences
Xingming Hou, Clemens Malainer, Atanas G. Atanasov, Elke H. Heiss, Verena M. Dirsch, Limei Wang, KeWei Wang
Summary: The natural alkaloid evodiamine was found to lower blood lipids and reduce hepatic lipid accumulation in HFD-fed mice, likely through promoting the PPARγ-ABCG1 signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Tom Hutteau-Hamel, Amine Mellouk, Nicolas Trainel, Anne-Marie Cassard, Pierre Bobe
Summary: This study reveals the relationship between membrane cholesterol content and ATP-induced cellular responses in T cells. In CD4(+) T cells, cholesterol content is positively correlated with CD62L shedding, pore formation, phosphatidylserine externalization, and cell death. In CD8(+) T cells, cholesterol, GM1, and P2X7 levels are negatively correlated with these cellular responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Nives Bogataj Jontez, Sasa Kenig, Karin Sik Novak, Ana Petelin, Zala Jenko Praznikar, Nina Mohorko
Summary: This study compared the dietary patterns of individuals following LCHF, vegan, vegetarian, and omnivorous diets. The results showed that compared to other groups, the LCHF group had higher intakes of saturated fats, cholesterol, and animal proteins, while the intakes of sugars and dietary fibers were lower. The levels of total and LDL cholesterol were significantly higher in the LCHF group. Thus, it is recommended to select healthy fat sources, increase dietary fiber intake, and partially replace animal sources with plant sources in the LCHF diet.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Yongshou Yang, Rikako Fukui, Huijuan Jia, Hisanori Kato
Summary: The study revealed that dietary supplementation with amaranth significantly reduced triglycerides, total cholesterol, and phospholipids levels in the liver, as well as downregulated the expression of lipogenesis-related genes. Amaranth supplementation also reversed the reduction in gut microbiota diversity and richness induced by a high-fat diet.
Article
Endocrinology & Metabolism
M. Croyal, Z. Kaabia, L. Leon, S. Ramin-Mangata, T. Baty, F. Fall, S. Billon-Crossouard, A. Aguesse, T. Hollstein, D. R. Sullivan, E. Nobecourt, G. Lambert, M. Krempf
DIABETES & METABOLISM
(2018)
Article
Engineering, Biomedical
Taghreed MohammadRidha, Mourad Ait-Ahmed, Lucy Chaillous, Michel Krempf, Isabelle Guilhem, Jean-Yves Poirier, Claude H. Moog
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2018)
Article
Nutrition & Dietetics
Claire Mayer, Martine Come, Lionel Ulmann, Graziella Chini Zittelli, Cecilia Faraloni, Hassan Nazih, Khadija Ouguerram, Benoit Chenais, Virginie Mimouni
Article
Chemistry, Medicinal
Ana Camila Dos Santos Dias, Aurelie Couzinet-Mossion, Nicolas Ruiz, Fatima Lakhdar, Samira Etahiri, Samuel Bertrand, Lucie Ory, Christos Roussakis, Yves Francois Pouchus, El-Hassane Nazih, Gaetane Wielgosz-Collin
Article
Chemistry, Analytical
Lucie Ory, El-Hassane Nazih, Sahar Daoud, Julia Mocquard, Melanie Bourjot, Laure Margueritte, Marc-Andre Delsuc, Jean-Marie Bard, Yves Francois Pouchus, Samuel Bertrand, Catherine Roullier
ANALYTICA CHIMICA ACTA
(2019)
Article
Biochemistry & Molecular Biology
Josiane Elia, Delphine Carbonnelle, Cedric Loge, Lucie Ory, Jean-Michel Huvelin, Mona Tannoury, Mona Diab-Assaf, Karina Petit, Hassan Nazih
LIPIDS IN HEALTH AND DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Mojgan Gharipour, Khadija Ouguerram, El-Hassane Nazih, Mansoor Salehi, Mehrdad Behmanesh, Rouzbeh Razavi, Amin Gharipour, Minoo Diantkhah, Masoumeh Sadeghi
MOLECULAR BIOLOGY REPORTS
(2019)
Review
Biochemistry & Molecular Biology
Hassan Nazih, Jean Marie Bard
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Integrative & Complementary Medicine
Mhamed Ramchoun, Tarik Khouya, Hicham Harnafi, Souliman Amrani, Chakib Alem, Mohamed Benlyas, Fatima Chadli, El-Hassane Nazih, Patrick Nguyen, Khadija Ouguerram
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biochemical Research Methods
Lucie Ory, Emmanuel Gentil, Decha Kumla, Anake Kijjoa, El-Hassane Nazih, Catherine Roullier
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2020)
Article
Nutrition & Dietetics
Christine Bobin-Dubigeon, Jean-Marie Bard, Trang-Huyen Luu, Francoise Le Vacon, Hassan Nazih
Summary: The study suggests that there is an interaction between microbiota and intestinal cell lipid metabolism, which may influence cancer disease.
Article
Nutrition & Dietetics
Christine Bobin-Dubigeon, Huyen Trang Luu, Sebastien Leuillet, Sidonie N. Lavergne, Thomas Carton, Francoise Le Vacon, Catherine Michel, Hassane Nazih, Jean-Marie Bard
Summary: This study found that early breast cancer patients have decreased microbial diversity, increased relative abundance of Firmicutes, and decreased relative abundance of Bacteroidetes in their intestinal microbiota compared to healthy controls. Additionally, a trend towards decreased relative abundance of Odoribacter sp., Butyricimonas sp., and Coprococcus sp. was observed in the patients.
Article
Medicine, General & Internal
Christine Bobin-Dubigeon, Hassan Nazih, Valentin Blanchard, Mikael Croyal, Jean-Marie Bard
Summary: This study evaluates the significance of measuring circulating lipoprotein apolipoproteins in breast cancer. The concentrations of apolipoproteins in plasma and various lipoproteins were determined, and the findings indicate a connection between the distribution of exchangeable apolipoproteins and the severity of breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Christine Bobin-Dubigeon, Hassan Nazih, Mikael Croyal, Jean-Marie Bard
Summary: According to the findings from clinical and laboratory data, researchers discovered a correlation between EPA and DHA carried by non-HDL lipoproteins and breast cancer severity, suggesting a potential protective effect on the proliferation of breast cancer in HR- tumors.
Article
Cardiac & Cardiovascular Systems
Francois Schiele, Michel Farnier, Michel Krempf, Eric Bruckert, Jean Ferrieres
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2018)