CLCAs - A Family of Metalloproteases of Intriguing Phylogenetic Distribution and with Cases of Substituted Catalytic Sites

CLCA2 as a p53-Inducible Senescence Mediator

(2015) Chizu Tanikawa et al.   NEOPLASIA

Increased human Ca2+-activated Cl- channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients

(2013) Hiroki Iwashita et al.   RESPIRATORY RESEARCH

mCLCA3 Does Not Contribute to Calcium-Activated Chloride Conductance in Murine Airways

(2012) Lars Mundhenk et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protease signalling: the cutting edge

(2012) Boris Turk et al.   EMBO JOURNAL

The Structure of Mlc Titration Factor A (MtfA/YeeI) Reveals a Prototypical Zinc Metallopeptidase Related to Anthrax Lethal Factor

(2012) Q. Xu et al.   JOURNAL OF BACTERIOLOGY

Self-cleavage of Human CLCA1 Protein by a Novel Internal Metalloprotease Domain Controls Calcium-activated Chloride Channel Activation

(2012) Zeynep Yurtsever et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum

(2012) Melanie K. Bothe et al.   MOLECULES AND CELLS

A Novel Extracellular Metallopeptidase Domain Shared by Animal Host-Associated Mutualistic and Pathogenic Microbes

(2012) Sirintra Nakjang et al.   PLoS One

A Novel Protein Kinase-Like Domain in a Selenoprotein, Widespread in the Tree of Life

(2012) Małgorzata Dudkiewicz et al.   PLoS One

Evolution of microbes and viruses: a paradigm shift in evolutionary biology?

(2012) Eugene V. Koonin et al.   Frontiers in Cellular and Infection Microbiology

Widespread Horizontal Gene Transfer from Circular Single-stranded DNA Viruses to Eukaryotic Genomes

(2011) Huiquan Liu et al.   BMC EVOLUTIONARY BIOLOGY

The murine goblet cell protein mCLCA3 is a zinc-dependent metalloprotease with autoproteolytic activity

(2011) Melanie K. Bothe et al.   MOLECULES AND CELLS

FFAS server: novel features and applications

(2011) L. Jaroszewski et al.   NUCLEIC ACIDS RESEARCH

Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database

(2011) M. Punta et al.   NUCLEIC ACIDS RESEARCH

Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis

(2011) V Walia et al.   ONCOGENE

Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog

(2011) Theodoros Goulas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opportunity and Means: Horizontal Gene Transfer from the Human Host to a Bacterial Pathogen

(2011) M. T. Anderson et al.   mBio

DUFs: families in search of function

(2010) Alex Bateman et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads cluster

(2010) H. Blanchard et al.   BIOCHIMIE

A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins.

(2010) Krzysztof Pawlowski et al.   BMC GENOMICS

Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism

(2010) Eva Lattka et al.   CURRENT OPINION IN LIPIDOLOGY

Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals

(2010) Holger Steuber et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases

(2010) Núria Cerdà-Costa et al.   MOLECULAR MICROBIOLOGY

SUPERFAMILY 1.75 including a domain-centric gene ontology method

(2010) D. A. de Lima Morais et al.   NUCLEIC ACIDS RESEARCH

Comparison of sequence profiles. Strategies for structural predictions using sequence information

(2010) Leszek Rychlewski et al.   PROTEIN SCIENCE

Matrix metalloproteinases: Fold and function of their catalytic domains

(2009) Cynthia Tallant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functional and ecological impacts of horizontal gene transfer in eukaryotes

(2009) Patrick J Keeling   CURRENT OPINION IN GENETICS & DEVELOPMENT

Discrete–continuous duality of protein structure space

(2009) Ruslan I Sadreyev et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Extracellular Proteases as Targets for Drug Development

(2009) Mare Cudic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Catalytic Domain Architecture of Metzincin Metalloproteases

(2009) F. Xavier Gomis-Rüth   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane

(2009) Jeong Su Oh et al.   MOLECULES AND CELLS

ACLAME: A CLAssification of Mobile genetic Elements, update 2010

(2009) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Horizontal gene transfer and the earliest stages of the evolution of life

(2009) Anthony M. Poole   RESEARCH IN MICROBIOLOGY

Exploration of Uncharted Regions of the Protein Universe

(2009) Lukasz Jaroszewski et al.   PLOS BIOLOGY

The Role of CLCA Proteins in Inflammatory Airway Disease

(2008) Anand C. Patel et al.   Annual Review of Physiology

Tandem duplication, circular permutation, molecular adaptation: how Solanaceae resist pests via inhibitors

(2008) Lesheng Kong et al.   BMC BIOINFORMATICS

A database of phylogenetically atypical genes in archaeal and bacterial genomes, identified using the DarkHorse algorithm

(2008) Sheila Podell et al.   BMC BIOINFORMATICS