Article
Biochemistry & Molecular Biology
Dandan Liu, Yiting Guo, Junsong Zhu, Weijie Tian, Min Chen, Haile Ma
Summary: Enzymatic hydrolysis of walnut protein to produce walnut peptide with antihypertensive activity may not be necessary, as both walnut protein and walnut hydrolysate demonstrated significant blood pressure lowering effects in in vivo experiments. The mechanism of antihypertensive activities involves regulating the renin-angiotensin-aldosterone system and the kallikrein-kinin system, as well as endothelium-derived vasoconstrictor and relaxing factors.
Review
Chemistry, Medicinal
Mojtaba Yousefi, Mahdi Shadnoush, Nasim Khorshidian, Amir M. Mortazavian
Summary: Consumption of fruits and vegetables rich in vitamins, minerals, and phytochemicals is an effective therapeutic for managing hypertension. Berry fruits contain various bioactive compounds with antioxidant, antimicrobial, anticancer, and anti-inflammatory properties. The bioactive compounds in berries play a significant role in mitigating hypertension by improving vascular function, inhibiting ACE activity, increasing eNOS activity and NO production, as well as having anti-oxidative and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mariana Luz-Veiga, Manuela Amorim, Ines Pinto-Ribeiro, Ana L. S. Oliveira, Sara Silva, Ligia L. Pimentel, Luis M. Rodriguez-Alcala, Raquel Madureira, Manuela Pintado, Joao Azevedo-Silva, Joao Fernandes
Summary: Cannabidiol (CBD) and cannabigerol (CBG) are phytocannabinoids found in Cannabis sativa L. They have antimicrobial activity against bacteria and biofilms, with CBG showing higher activity than CBD. These findings suggest that phytocannabinoids could be promising topical antimicrobial agents for treating various skin conditions. Further research is needed to understand their mechanisms of action and develop practical applications in dermatology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Dongru Chen, Jing Li, Ting Pan, Ruixue Wu, Ye Tao, Huancai Lin
Summary: This study simulated short amyloid-forming peptides derived from Streptococcus mutans and found that they have efficient broad-spectrum antibiofilm activity against various bacteria and fungi, by aggregating into amyloid fibres. The peptides bind to microbial cell wall carbohydrates and trigger significant fibrillation, highlighting their potential use as novel antibiofilm agents.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Joo Youn Oh, Hyemee Kim, Hyun Ju Lee, Kangin Lee, Heather Barreda, Hyeon Ji Kim, Eunji Shin, Eun-Hye Bae, Gagandeep Kaur, Yu Zhang, Eunjae Kim, Jae Young Lee, Ryang Hwa Lee
Summary: This study found that inhibiting MHC class I in MSCs reduces their survival rate and immunosuppressive potency, while increasing their susceptibility to NK-cell-mediated cytotoxicity. There is a significant correlation between MSC survival rate and susceptibility to NK cells, as well as the potency of MSCs to increase MHC class I level upon stimulation.
Article
Chemistry, Multidisciplinary
Laszlo Keresztes, Evelin Szogi, Balint Varga, Viktor Farkas, Andras Perczel, Vince Grolmusz
Summary: Hexapeptides are widely used to study the amyloid-forming properties of polypeptides. By utilizing artificial intelligence classifiers, researchers have successfully predicted the amyloid state of peptides. In this study, the Budapest Amyloid Predictor was applied to discover amyloidogenic and nonamyloidogenic hexapeptide patterns with high accuracy, providing novel rules for understanding the amyloid state of peptides.
Article
Chemistry, Medicinal
Qingxuan Zeng, Hongbin Deng, Yinghong Li, Tianyun Fan, Yang Liu, Sheng Tang, Wei Wei, Xiaojia Liu, Xixi Guo, Jiandong Jiang, Yanxiang Wang, Danqing Song
Summary: Berberine directly targets the NEK7 protein via hydrogen bonding, inhibiting the NEK7-NLRP3 interaction and subsequent IL-1 beta release. NEK7 is considered a key target of BBR in the treatment of NLRP3-related inflammatory diseases, and the development of novel inhibitors targeting the NEK7-NLRP3 interaction may be achievable.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Yijia Xu, Wenwen Li, Ruojin Wen, Jianfang Sun, Xin Liu, Shangfeng Zhao, Jinghai Zhang, Yanfeng Liu, Mingyi Zhao
Summary: The study aimed to identify the mechanisms responsible for the pharmacological activity and cardiotoxicity of the main monomers of Tripterygium wilfordii. It was found that the monomers could bind to ion channels and inhibit their currents, exhibit analgesic effects on formalin-induced pain, and one monomer showed potential cardiac risk. These findings provide an important theoretical basis for the further screening of active monomers with higher levels of activity and lower levels of toxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Dermatology
Silvia Albertini, Licia Martuscelli, Cinzia Borgogna, Sanamjeet Virdi, Daniela Indenbirken, Irene Lo Cigno, Gloria Griffante, Federica Calati, Renzo Boldorini, Nicole Fischer, Marisa Gariglio
Summary: The tumor microenvironment, consisting of extracellular matrix, blood vessels, immune cells, and fibroblasts, plays a crucial role in cancer development. However, its involvement in Merkel cell carcinoma (MCC) is unknown. In this study, we characterized cancer-associated fibroblasts (CAFs) in patient-derived xenografts of MCC. We found that injection of patient-derived CAFs with MCC cells promoted tumor growth and metastasis, mainly localized around blood vessels. We identified aminopeptidase A as a potential marker for MCC prognosis and therapeutic target.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tsvetelina Batsalova, Yordan Georgiev, Dzhemal Moten, Ivanka Teneva, Balik Dzhambazov
Summary: This study aimed to evaluate the cytotoxicity and inhibitory potential of commercially available xylooligosaccharides (XOS) derived from corn against tumor cells. It was found that XOS exhibited antioxidant activity and showed remarkable inhibitory effect on lysosomes. However, it also affected mitochondrial functionality. XOS treatment reduced the production of proinflammatory cytokines and had a tumor-cell-specific influence on the glutathione antioxidant system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Nishithkumar Jogi, Undiganalu Gangadharappa Yathisha, Ishani Bhat, Bangera Sheshappa Mamatha
Summary: Food proteins are sources for ACE-I inhibitory peptides that can be extracted by enzymatic hydrolysis and exhibit anti-hypertensive activity. However, these peptides are susceptible to degradation by gastrointestinal enzymes during oral consumption. The bio-activity of ACE-I inhibitory peptides is dependent on their intact absorption after gastrointestinal digestion.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Peng Zhang, Changjuan Tao, Takaya Shimura, Andrew C. Huang, Nana Kong, Yujie Dai, Shili Yao, Yun Xi, Xing Wang, Jianmin Fang, Marsha A. Moses, Peng Guo
Summary: Through bioinformatic expression analyses and immunohistochemistry staining, we identified ICAM1 as an attractive target for ATC and PTC. We developed ICAM1-directed antibody-drug conjugates, I1-MMAE and I1-DXd, which effectively eliminated ATC and PTC cells without affecting non-cancerous cells in vitro. In vivo studies demonstrated significant tumor regression in ATC and PTC xenograft models. Additionally, we explored MRI as a non-invasive biomarker detection method for ICAM1 antigen expression in heterogeneous thyroid tumors. This study provides a strong rationale for the further development of I1-MMAE and I1-DXd as promising therapeutic candidates for advanced PTC and ATC.
Review
Chemistry, Multidisciplinary
Cheng Tan, Shou-Jun Yang, Dong-Hai Zhao, Jia Li, Li-Quan Yin
Summary: Heterocyclic compounds play an important role in chemistry due to their wide range of applications in drug design, photochemistry, agrochemicals, and other fields. Indole and indazole derivatives have various biological activities, including antihypertensive effects. This review focuses on the mechanisms of action of indole and indazole derivatives in reducing blood pressure.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Alvaro Villanueva-Lazo, Sergio Montserrat-de la Paz, Noelia Maria Rodriguez-Martin, Francisco Millan, Cecilio Carrera, Justo Javier Pedroche, Maria del Carmen Millan-Linares
Summary: The study demonstrated that CPH15A obtained by Alcalase hydrolysis has potent antihypertensive and antioxidant properties, making it an effective alternative to other plant protein ingredients in the food industry.
Article
Food Science & Technology
Ines Abad, Julien Vignard, Catherine Bouchenot, Dimitra Graikini, Laura Grasa, Maria Dolores Perez, Gladys Mirey, Lourdes Sanchez
Summary: This study evaluated the antioxidant and antigenotoxic effects of milk-derived products in two human cell lines. The results showed that these dairy fractions significantly reversed oxidative stress and lactoferrin exhibited the highest antioxidant activity. Additionally, dairy by-products maintained their activity in a coculture of intestinal and hepatic cells, suggesting their potential use in food specialties.
Article
Food Science & Technology
Nan Zhang, Zhengjun He, Siyu He, Pu Jing
FOOD RESEARCH INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Zhen Ma, Govindarajan Prasanna, Linlei Jiang, Pu Jing
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Food Science & Technology
Nan Zhang, Tisong Liang, Quan Jin, Cai Shen, Yifan Zhang, Pu Jing
FOOD RESEARCH INTERNATIONAL
(2019)
Article
Chemistry, Applied
Tisong Liang, Zhentao Zhang, Pu Jing
Article
Food Science & Technology
Wei Xu, Nan Zhang, Zhentao Zhang, Pu Jing
FOOD RESEARCH INTERNATIONAL
(2019)
Article
Agricultural Engineering
Shankar Subramaniam, Xin-Yao Wen, Pu Jing
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Review
Food Science & Technology
Shankar Subramaniam, Shunshun Jiao, Zhentao Zhang, Pu Jing
Summary: This review examines the factors affecting the quality decline of fresh and dried shiitake mushrooms, discusses various methods for preserving their quality, and evaluates the efficiency and impact of these methods.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Food Science & Technology
Tisong Liang, Shunshan Jiao, Pu Jing
Summary: The interactions between high methoxyl pectin and catechin/procyanidin in a simulative juice model were found to affect the antioxidant activity of phenolics.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Food Science & Technology
Zhen Ma, Jing Cheng, Shunshan Jiao, Pu Jing
Summary: This study investigated the interaction mechanism between soybean protein isolate (SPI) and mulberry anthocyanins (MA) and found that it affects the thermal stability of anthocyanins and the digestibility of protein subunits.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Jianhua Liu, Jing Cheng, Zhen Ma, Tisong Liang, Pu Jing
Summary: This study explored the interactive effects of mulberry and corn protein on pigment stability and zein digestibility. Zein demonstrated a strong affinity for C3G, resulting in changes to its secondary structure and particle size. Although the interaction did not significantly impact zein digestion, it slightly enhanced anthocyanin thermal stability. These findings provide insights for the selection of ingredients rich in zein and anthocyanins in the food industry.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Chemistry, Applied
Xin-Yao Wen, Pu Jing
Summary: In this study, a rapid method using HPLC-ELSD was developed to detect and quantify cerebrosides from seven edible mushrooms. The results provide strong support for the application of cerebrosides from mushrooms.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Plant Sciences
Tisong Liang, Jiexin Zhou, Pu Jing, Zhengjun He, Shunshan Jiao, Wenji Zhao, Qi Tong, Guofu Jia
Summary: The aim of this study was to explore the relationship between phytochemical profiles and activities of Rhodiola crenulata (Rc) extracts. The study found that the 70% ethanol extracts exhibited better effects on senescence regulation and antioxidant activities. A total of 14 phytochemicals were identified in the extracts, and they might exhibit additive or synergistic effects. These findings provide a theoretical basis for the daily use of Rc.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Food Science & Technology
Tisong Liang, Pu Jing, Jian He
Summary: Anthocyanins (ACNs), a subgroup of flavonoids, have received considerable attention due to their nutritional values. However, their application is limited by poor stability and bioavailability. Nanoencapsulation has emerged as a promising approach to enhance their stability and bio-efficacy. This review focuses on the application of nano-techniques in delivery systems for ACNs, highlighting physicochemical stability and health benefits. ACNs incorporated into nanoparticles and fibrils exhibit improved stability, enhanced bioavailability, and controlled release. The toxicological evaluation of nano delivery systems is also discussed. The challenges and future perspectives for the application of ACNs delivery systems in food and medical fields are summarized.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Nan Zhang, Pu Jing
Summary: Research suggests that red cabbage anthocyanins may have health benefits associated with antiaging. In a study on aging mice, it was found that extracts rich in red cabbage anthocyanins and cyanidin-3-diglucoside-5-glucoside significantly reduced cognitive impairment and had no effect on motor disorder. These extracts also increased antioxidant activity and reduced neuronal damage and neuroinflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Siyu He, Nan Zhang, Pu Jing
