TWEAK-Independent Fn14 Self-Association and NF-κB Activation Is Mediated by the C-Terminal Region of the Fn14 Cytoplasmic Domain

Elevated Expression of Fn14 in Non-Small Cell Lung Cancer Correlates with Activated EGFR and Promotes Tumor Cell Migration and Invasion

(2012) Timothy G. Whitsett et al.   AMERICAN JOURNAL OF PATHOLOGY

The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models

(2012) Jennifer S. Michaelson et al.   CANCER BIOLOGY & THERAPY

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Death Receptor 5 Networks That Are Highly Organized

(2012) Christopher C. Valley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb

(2012) Debra T. Chao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The TWEAK Receptor Fn14 Is a Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment

(2012) Hong Zhou et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-Induced Migration and Invasion of Glioblastoma Cells

(2012) S. P. Fortin et al.   MOLECULAR CANCER RESEARCH

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome

(2011) Mingguo Huang et al.   CARCINOGENESIS

TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

(2011) Linda C. Burkly et al.   IMMUNOLOGICAL REVIEWS

Development of an Fn14 agonistic antibody as an anti-tumor agent

(2011) Jennifer S. Michaelson et al.   mAbs

Development and Characterization of a Potent Immunoconjugate Targeting the Fn14 Receptor on Solid Tumor Cells

(2011) H. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Antibodies to TWEAK Receptor Inhibit Human Tumor Growth through Dual Mechanisms

(2010) P. A. Culp et al.   CLINICAL CANCER RESEARCH

Full-length, Membrane-anchored TWEAK Can Function as a Juxtacrine Signaling Molecule and Activate the NF-κB Pathway

(2010) Sharron A. N. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing and evolution: diversification, exon definition and function

(2010) Hadas Keren et al.   NATURE REVIEWS GENETICS

TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21

(2010) Ana B. Sanz et al.   PLoS One

Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily

(2010) Fahu He et al.   PROTEIN SCIENCE

A Novel Role for Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) in the Development of Cardiac Dysfunction and Failure

(2009) Mohit Jain et al.   CIRCULATION

TNF-Like Weak Inducer of Apoptosis (TWEAK) Activates Proinflammatory Signaling Pathways and Gene Expression through the Activation of TGF- -Activated Kinase 1

(2009) M. Kumar et al.   JOURNAL OF IMMUNOLOGY

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Stimulation of Glioma Cell Survival Is Dependent on Akt2 Function

(2009) S. P. Fortin et al.   MOLECULAR CANCER RESEARCH

Picomole-level mapping of protein disulfides by mass spectrometry following partial reduction and alkylation

(2008) Susan F. Foley et al.   ANALYTICAL BIOCHEMISTRY

TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis

(2008) Taeko Dohi et al.   GASTROENTEROLOGY

Tumor Necrosis Factor-related Weak Inducer of Apoptosis Augments Matrix Metalloproteinase 9 (MMP-9) Production in Skeletal Muscle through the Activation of Nuclear Factor-κB-inducing Kinase and p38 Mitogen-activated Protein Kinase

(2008) Hong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

The Fibroblast Growth Factor-Inducible 14 Receptor Is Highly Expressed in HER2-Positive Breast Tumors and Regulates Breast Cancer Cell Invasive Capacity

(2008) A. L. Willis et al.   MOLECULAR CANCER RESEARCH

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY