Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase

(2011) Victor Kenyon et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Azole Binding Properties of Candida albicans Sterol 14-  Demethylase (CaCYP51)

(2010) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Substituted pyrazoles as novel sEH antagonist: Investigation of key binding interactions within the catalytic domain

(2010) Ho Yin Lo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Lipoxygenase inhibitors: a review of recent developments and patents

(2010) Carlo Pergola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1

(2010) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor

(2010) Yves Ducharme et al.   ACS Medicinal Chemistry Letters

5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)

(2009) John H. Hutchinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using Enzyme Assays to Evaluate the Structure and Bioactivity of Sponge-Derived Meroterpenes

(2009) Sarah J. Robinson et al.   JOURNAL OF NATURAL PRODUCTS

Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

(2008) Justin D. Lutz et al.   BIOCHEMICAL PHARMACOLOGY

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

(2008) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY