Frequent Engagement of RelB Activation Is Critical for Cell Survival in Multiple Myeloma

NF- B, the first quarter-century: remarkable progress and outstanding questions

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NF-κB: where did it come from and why?

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Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors

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Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

Latest advances and current challenges in the treatment of multiple myeloma

(2012) Anuj Mahindra et al.   Nature Reviews Clinical Oncology

RelB inhibits cell proliferation and tumor growth through p53 transcriptional activation

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Hallmarks of Cancer: The Next Generation

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Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed–Sternberg cells

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Multiple Myeloma

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Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

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Multiple Myeloma

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Classical and/or alternative NF- B pathway activation in multiple myeloma

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Oncogenic Activation of NF- B

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Biologic sequelae of I B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

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NF-κB and cancer—identifying targets and mechanisms

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NF-??B in the pathogenesis and treatment of multiple myeloma

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NF-κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes

(2008) Amanda J Fusco et al.   EMBO REPORTS

Bortezomib-Resistant Nuclear Factor- B Activity in Multiple Myeloma Cells

(2008) S. Markovina et al.   MOLECULAR CANCER RESEARCH

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY