Depressive Symptoms in Crohn's Disease: Relationship with Immune Activation and Tryptophan Availability

Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2×2 clinical trial

(2012) Jonathan Savitz et al.   BMJ Open

Effects of adalimumab therapy on disease activity and interferon-γ-mediated biochemical pathways in patients with rheumatoid arthritis

(2011) Katharina Kurz et al.   AUTOIMMUNITY

Mood and nonmood components of perceived stress and exacerbation of Crohnʼs disease

(2011) Rafael J.A. Cámara et al.   INFLAMMATORY BOWEL DISEASES

Mechanism of acute tryptophan depletion: is it only serotonin?

(2011) E L van Donkelaar et al.   MOLECULAR PSYCHIATRY

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Proinflammatory cytokines underlying the inflammation of Crohnʼs disease

(2010) Warren Strober et al.   CURRENT OPINION IN GASTROENTEROLOGY

Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?

(2010) Gunter Kenis et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Crohn's disease and fatigue: Constancy and co-variations of activity of the disease, depression, anxiety and subjective quality of life

(2010) Ingrid Banovic et al.   Psychology Health & Medicine

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

The effect of tumor necrosis factor antagonists on mood and mental health-associated quality of life: Novel hypothesis-driven treatments for bipolar depression?

(2009) Joanna K. Soczynska et al.   NEUROTOXICOLOGY

Effects of Adalimumab Maintenance Therapy on Health-Related Quality of Life of Patients With Crohn's Disease: Patient-Reported Outcomes of the CHARM Trial

(2008) Edward V. Loftus et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Perception of improved state of health and subjective quality of life in Crohn's disease patients treated with Infliximab

(2008) Ingrid Banovic et al.   Journal of Crohns & Colitis

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE