Article
Gastroenterology & Hepatology
Erica J. Brenner, Millie D. Long, Courtney M. Mann, Li Lin, Wenli Chen, Camila Reyes, Kirsten M. Bahnson, Bryce B. Reeve, Michael D. Kappelman
Summary: The study found that anxiety and depressive symptoms in pediatric CD patients are not significantly associated with worsening disease activity.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Psychiatry
Yajun Yun, Qi Zhang, Wenxuan Zhao, Ting Ma, Hongzhen Fan, Luyuan Bai, Botao Ma, Siyuan Qi, Zhiren Wang, Huimei An, Fude Yang
Summary: The study found a relationship between the tryptophan-kynurenine pathway and painful physical symptoms in major depressive disorder. Patients with painful physical symptoms showed higher levels of kynurenine and quinolinic acid, and a higher kynurenine/tryptophan ratio. There was a positive correlation between the scores of the Short-form McGill pain questionnaire and quinolinic acid levels, and a negative correlation with tryptophan levels or the kynurenic acid/quinolinic acid ratio. Regression analysis identified the kynurenine/tryptophan ratio, the kynurenic acid/quinolinic acid ratio, and the Hamilton Depression Scale scores as significant predictors of the Short-form McGill pain questionnaire scores.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gustavo Ignacio Vazquez Cervantes, Javier Angel Navarro Cossio, Gonzalo Perez de la Cruz, Aleli Salazar, Veronica Perez de la Cruz, Benjamin Pineda
Summary: The study discovered that enzymes associated with indoleamine dioxygenase (IDO) are overexpressed in various brain tumors and positively correlated with immune response modulation, angiogenesis, signal transduction, Signal Transducer and Activator of Transcription (STAT) signaling, and Rho GTPase gene expression, suggesting their importance in the pathogenesis of brain tumors.
Article
Neurosciences
Peng Cao, Changmao Chen, An Liu, Qinghong Shan, Xia Zhu, Chunhui Jia, Xiaoqi Peng, Mingjun Zhang, Zahra Farzinpour, Wenjie Zhou, Haitao Wang, Jiang-Ning Zhou, Xiaoyuan Song, Liecheng Wang, Wenjuan Tao, Changjian Zheng, Yan Zhang, Yu-Qiang Ding, Yan Jin, Lin Xu, Zhi Zhang
Summary: Early-life inflammation can increase the risk for depression in later life by affecting the long-term neuronal spine engulfment capacity of microglia. Mouse studies have shown that depressive-like stress can increase microglial engulfment of specific neuronal spines, and inhibiting microglial activity may reduce depressive symptoms.
Article
Medicine, General & Internal
Zhen Zhang, Wen-Hao Zhang, Yin-Xiao Lu, Bo-Xuan Lu, Yi-Bo Wang, Li-Ying Cui, Hao Cheng, Zhen-Yu Yuan, Jie Zhang, Da-Peng Gao, Jian-Feng Gong, Qing Ji
Summary: This study aimed to investigate the effects of S-ketamine on postoperative depression, pain, and inflammation in patients with Crohn's disease undergoing bowel resection. The results showed that patients in the S-ketamine group had lower scores of depression and pain, and higher quality of recovery scores compared to the placebo group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Hiba Bilal, Ian H. Harding, Julie C. Stout
Summary: Huntington's disease (HD) is a genetic neurodegenerative disease characterized by motor abnormalities, cognitive decline, and psychological difficulties. Depression is a common psychological difficulty in HD. Understanding the relationship between HD-specific psychosocial stressors and depression symptoms is crucial for treatment and developing a disease-specific model of depression in HD.
JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Weiming Lai, Ziheng Huang, Sheng Li, Xiang-Guang Li, Ding Luo
Summary: Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract and is often accompanied by depressive symptoms. The dysregulated immune response and neuroglial dysfunction play important roles in the development of chronic inflammation and depression. The kynurenine pathway (KP) is a significant metabolite pathway that regulates chronic inflammation and depressive symptoms. KP metabolites, especially quinolinic acid, accumulate in the brain and contribute to the comorbidity of IBD and depression. This review summarizes the pathological mechanisms of KP metabolite-mediated chronic intestinal inflammation and depressive symptoms by regulating the immune response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
Roger Suau, Eva Pardina, Eugeni Domenech, Violeta Loren, Josep Manye
Summary: In recent years, there has been a growing interest in the pathological involvement of creeping fat in Crohn's disease (CD). Despite its protective nature, the abnormal inflammatory activity of creeping fat may worsen the severity of CD, and the inflammatory process associated with CD involves various cellular and molecular changes.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Microbiology
Yiming Zhao, Lulu Chen, Liyu Chen, Jing Huang, Shuijiao Chen, Zheng Yu
Summary: The interaction between diet and gut microbiota plays a crucial role in the pathogenesis of Crohn's disease. This study explored the effects of a high-protein diet (HPD) on the gut microbiota and found that changes in the gut microbiome after HPD were similar to those in patients with Crohn's disease. Specifically, Escherichia coli was identified as a marker for both Crohn's disease and HPD intervention.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Jun Wang, Guangyao Liu, Kun Xu, Kai Ai, Wenjing Huang, Jing Zhang
Summary: A growing body of evidence suggests that IBD is associated with alterations in the central nervous system and emotional symptoms. We found decreased GABA+ and Glx concentrations in the mPFC of IBD patients compared to healthy controls, as well as thin cortical thickness in specific brain regions.
HUMAN BRAIN MAPPING
(2023)
Review
Public, Environmental & Occupational Health
Oluseye Ogunmoroti, Olatokunbo Osibogun, Erica S. Spatz, Victor Okunrintemi, Lena Mathews, Chiadi E. Ndumele, Erin D. Michos
Summary: The bidirectional relationship between depressive symptoms and cardiovascular health might exist, further research is needed to quantify the risk and identify the biological mechanisms underlying the association.
PREVENTIVE MEDICINE
(2022)
Article
Clinical Neurology
Ashley M. Shaw, Elizabeth R. Halliday, Niza A. Tonarely, Jill Ehrenreich-May
Summary: The study found a relationship between affect intolerance and internalizing symptoms in youth, with higher levels of affect intolerance predicting more severe symptom reports. Future research should include more samples of depressed youth and utilize experimental or longitudinal methods to validate the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nutrition & Dietetics
Iolanda Cioffi, Olivia Di Vincenzo, Nicola Imperatore, Mariagrazia Fisco, Anna Testa, Filippo Scialo, Fabiana Castiglione, Margherita Ruoppolo, Fabrizio Pasanisi, Lidia Santarpia
Summary: This study explored the variations in serum amino acid concentrations in adult patients with Crohn's disease (CD). It found that specific amino acids varied according to disease activity and protein intake, and were associated with inflammatory markers.
FRONTIERS IN NUTRITION
(2023)
Review
Humanities, Multidisciplinary
Seungjong Cho
Summary: This study synthesizes the current theoretical knowledge on the relationship between neighbourhood stressors and depressive symptoms. It identifies the social disorganization theory and stress process theory as the two most relevant sociological theories and provides a detailed review and critique of both theories. The study suggests a conceptual model of neighbourhood stressors, psychosocial resources, and depressive symptoms.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jack L. Andrews, Tim Dalgleish, Jason Stretton, Susanne Schweizer
Summary: Research examines the relationship between mental health problems and reduced capacity for reappraisal, using a film-based emotion regulation task. Data from 6 independent studies on 512 participants reveal that symptoms of depression and anxiety do not affect self-reported negative affect or emotional reactivity to negative films after reappraisal. The study discusses implications for measuring reappraisal and future research directions in emotion regulation.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
Cecile Henquet, Jim van Os, Lotta K. Pries, Christian Rauschenberg, Philippe Delespaul, Gunter Kenis, Jurjen J. Luykx, Bochao D. Lin, Alexander L. Richards, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan, Haldun Soygur, Halis Ulas, Eylem S. Cankurtaran, Semra U. Kaymak, Marina M. Mihaljevic, Sanja S. Petrovic, Tijana Mirjanic, Miguel Bernardo, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A. Saiz, Maria P. Garcia-Portilla, Julio Sanjuan, Eduardo J. Aguilar, Jose L. Santos, Estela Jimenez-Lopez, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Nadja P. Maric, Cem Atbasoglu, Alp Ucok, Koksal Alptekin, Meram C. Saka, Celso Arango, Michael O'Donovan, Bart P. F. Rutten, Sinan Guloksuz
Summary: The study replicated that JTC bias is associated with familial liability for psychosis, and this association is stronger in individuals with higher levels of delusional ideation. The association between JTC bias and sibling status is not stronger in those with higher levels of hallucinatory experiences.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Jim van Os, Lotta-Katrin Pries, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Philippe Delespaul, Maarten Bak, Gunter Kenis, Bochao D. Lin, Jurjen J. Luykx, Alexander L. Richards, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan, Haldun Soygur, Halis Ulas, Eylem Sahin Cankurtaran, Semra Ulusoy Kaymak, Marina M. Mihaljevic, Sanja Andric Petrovic, Tijana Mirjanic, Miguel Bernardo, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A. Saiz, Maria Paz Garcia-Portilla, Julio Sanjuan, Eduardo J. Aguilar, Jose Luis Santos, Estela Jimenez-Lopez, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Nadja P. Maric, Cem Atbasoglu, Alp Ucok, Koksal Alptekin, Meram Can Saka, Celso Arango, Michael O'Donovan, Bart P. F. Rutten, Sinan Guloksuz
Summary: The study reveals that the impact of genetic and non-genetic risk factors for schizophrenia on psychosis outcomes is partially mediated through an affective pathway.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Martijn J. Kikkert, Wim Veling, Lieuwe de Haan, Marieke J. H. Begemann, Mariken de Koning, Iris E. Sommer
Summary: There is a ongoing debate on the optimal timing of discontinuation of antipsychotic drugs for patients with first episode psychosis. Research shows that early discontinuation may be beneficial for some patients, but there is substantial practice variation among clinicians. Future research on long-term effects of early medication discontinuation can help guide evidence-based treatment decisions for first-episode patients.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
N. de Boer, J. Vermeulen, B. Lin, J. van Os, M. ten Have, R. de Graaf, S. van Dorsselaer, M. Bak, B. Rutten, A. Batalla, S. Guloksuz, J. J. Luykx
Summary: This study aimed to examine the relationships between smoking, alcohol use, and mood disorders. The results showed that smoking and the number of cigarettes per day were positively associated with depressive symptoms, while moderate alcohol consumption was associated with a reduction in symptoms. Longitudinally, reductions in smoking behavior and alcohol consumption were associated with improvements in depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jim van Os, Lotta-Katrin Pries, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Maarten Bak, Gunter Kenis, Bochao D. Lin, Nicole Gunther, Jurjen J. Luykx, Bart P. F. Rutten, Sinan Guloksuz
Summary: Background: Combining the contextual clinical characterization framework with categorical algorithm-based diagnosis can provide more clinical value to patients. Methods: Prospective analysis of data from multiple domains to predict the impact on care needs and healthcare outcomes. Results: The predictive power of the contextual clinical characterization components in joint models exceeded that of any individual component, and the polygenic risk scores did not contribute significantly to the models. Conclusion: The transdiagnostic framework of contextual clinical characterization is more valuable to patients than a categorical system of algorithmic ordering of psychopathology.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Experimental
Kristof Hoorelbeke, Nathan Van den Bergh, Rudi De Raedt, Marieke Wichers, Casper J. Albers, Ernst H. W. Koster
Summary: Studies suggest that cognitive control training has potential as a preventive intervention for depression, but little is known about its underlying mechanisms. This study used an experimental manipulation of cognitive control to investigate its direct effects on affect, emotion regulation, residual symptomatology, and resilience in remitted depressed patients. The findings showed that cognitive control training had beneficial effects on rumination and played a causal role in emotion regulation. However, it did not have immediate effects on residual symptoms or resilience, and did not impact the complex interplay between these variables. Overall, the immediate effects of cognitive control training on daily functioning were limited.
Article
Psychiatry
Fionneke M. Bos, Lino von Klipstein, Ando C. Emerencia, Erwin Veermans, Tom Verhage, Evelien Snippe, Bennard Doornbos, Grietje Hadders-Prins, Marieke Wichers, Harriette Riese
Summary: This study aims to develop a web-based application called Personalized Treatment by Real-time Assessment (PETRA) for integrating personalized ecological momentary assessment (EMA) in psychiatric care. Through interviews, focus groups, and usability sessions, the requirements for the application were determined, and high-fidelity prototypes were continuously improved based on feedback. PETRA is unique in its codevelopment process, extensive personalization options, integration into electronic health record systems, transdiagnostic focus, and scientific foundation in EMA diaries and feedback. The clinical effectiveness of PETRA in routine mental health care requires further research.
JMIR MENTAL HEALTH
(2022)
Review
Psychiatry
Laura Fusar-Poli, Bart P. F. Rutten, Jim van Os, Eugenio Aguglia, Sinan Guloksuz
Summary: In recent years, the development of polygenic risk scores (PRSs) in psychiatry has been facilitated by the reduced costs and increased accessibility to large genome-wide association studies datasets. While PRS represent stable trait features with a normal distribution in the general population and are relatively easy to calculate in terms of time and costs, their real-world applicability is constrained by limitations such as low predictive power and lack of population diversity. Combining genomic and exposomic vulnerabilities with detailed clinical characterization is essential for personalized care in clinical psychiatry.
INTERNATIONAL REVIEW OF PSYCHIATRY
(2022)
Article
Psychology, Experimental
Marieke A. Helmich, Marieke Wichers, Frenk Peeters, Evelien Snippe
Summary: This study found that instability and variability of negative affect were related to current and future depressive symptoms. Higher levels of negative affect and baseline symptom severity predicted a greater reduction in depressive symptoms during treatment, while lower levels of negative affect were associated with a higher likelihood of reaching remission.
COGNITION & EMOTION
(2022)
Article
Health Care Sciences & Services
Arnout C. Smit, Evelien Snippe, Laura F. Bringmann, H. J. Rogier Hoenders, Marieke Wichers
Summary: The purpose of this study is to explore the meaningful changes in individual patients who stop taking antidepressant medication. The results show that there are differences between macro-level and micro-level changes in depressive symptoms, highlighting the importance of combining qualitative and quantitative assessments.
QUALITY OF LIFE RESEARCH
(2023)
Article
Psychology, Clinical
Marieke J. Schreuder, Catharina A. Hartman, Robin N. Groen, Arnout C. Smit, Marieke Wichers, Johanna T. W. Wigman
Summary: This study empirically investigated whether early-warning signals (EWSs) precede transitions towards psychopathology in at-risk youths. The results showed that EWSs had low sensitivity and moderate specificity, suggesting that their generic nature and clinical utility could not be substantiated.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Clinical
Marieke A. Helmich, Arnout C. Smit, Laura F. Bringmann, Marieke J. Schreuder, Albertine J. Oldehinkel, Marieke Wichers, Evelien Snippe
Summary: Drawing on dynamical systems theory, this study investigated whether early-warning signals in momentary affect could predict transitions to lower levels of depressive symptoms in individuals undergoing therapy for depression. The results showed that rising autocorrelation was found in 89% of individuals with transitions, and in a consistently higher proportion of the separate variables, compared to those without transitions. Rising variance was found for a few individuals, both preceding transitions and in individuals without transitions. In addition, some participants showed critical slowing down.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Clinical
Yoram K. Kunkels, Arnout C. Smit, Olga Minaeva, Evelien Snippe, Sandip V. George, Arie M. van Roon, Marieke Wichers, Harriette Riese
Summary: Discontinuation of antidepressants increases the risk of depressive symptoms. This study aimed to determine if transitions in depression were preceded by changes in actigraphy-based early-warning signals (EWSs), circadian-rhythm-based indicators, and mean activity levels. Data from 16 individuals with depression transitions and 9 without transitions were analyzed, showing that transitions were associated with increased EWSs. However, none of the tested risk indicators could confidently predict upcoming transitions in depression.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Neurosciences
Lotta-Katrin Pries, Tyler M. Moore, Elina Visoki, Ingrid Sotelo, Ran Barzilay, Sinan Guloksuz
Summary: The exposome factors are associated with mental disorders, particularly with prenatal, perinatal, and childhood adversities, which can help understand neurodevelopmental psychopathology.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
Review
Neurosciences
Ran Barzilay, Lotta-Katrin Pries, Tyler M. Moore, Raquel E. Gur, Jim van Os, Bart P. F. Rutten, Sinan Guloksuz
Summary: The prenatal period, early childhood, and adolescence are critical periods for brain development, and environmental exposures during these periods can have long-term effects on mental health. Psychosis spectrum disorder (PSD) is a developmental disorder that is influenced by both genetic and environmental factors. This review emphasizes the importance of studying the exposome and using a developmental lens to understand the environmental origins of PSD. It highlights the need for comprehensive assessments of environment, as well as the exploration of trans-syndromal manifestations, instead of focusing solely on categorical outcomes.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
