Article
Cell Biology
Chunhai Chen, Qinglong Ma, Ping Deng, Min Lin, Peng Gao, Mindi He, Yonghui Lu, Huifeng Pi, Zhixin He, Chao Zhou, Yanwen Zhang, Zhengping Yu, Lei Zhang
Summary: Research shows that RF-EMF exposure impairs neurite outgrowth through inhibiting EPHA5 signaling, which affects brain development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
James P. McNamee, Veronica S. Grybas, Sami S. Qutob, Pascale V. Bellier
Summary: The study found no consistent evidence of changes in the expression of signal transduction proteins or antioxidant proteins in response to exposure to 1800 MHz RF-EMF in a human-derived glioblastoma A172 cell line.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Chemistry, Analytical
Marco Xavier Rivera Gonzalez, Nazario Felix Gonzalez, Isabel Lopez, Juan Sebastian Ochoa Zambrano, Andres Miranda Martinez, Ceferino Maestu Unturbe
Summary: A novel compact device with spectrum analyzer characteristics has been designed to measure the entire communications spectrum and detect multiple sources of electromagnetic fields. The device was calibrated in an anechoic chamber for far-fields and validated against a portable spectrum analyzer in a residential area, showing a strong correlation with a confidence higher than 95%. This indicates that the device could be considered as an important tool for electromagnetic field studies.
Article
Biotechnology & Applied Microbiology
Zhen Ding, Xiaoyong Xiang, Jintao Li, Shuicai Wu
Summary: This study aimed to investigate the effect of RF-EMR on cell malignant transformation. The results showed that exposure of Balb/c-3T3 cells to 1800 MHz RF continuous wave for 40 and 60 days resulted in increased cell proliferation and migration, and the occurrence of malignant transformation. Lipid metabolism was identified as a key biological process and pathway.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Burcu Demirbag, Savas Aktas, Ulku Comelekog, Ilker Kara, Metin Yildirim, Didem Derici Yildirim
Summary: This study investigated the potential protective effects of paricalcitol in testicular damage caused by 1800 MHz radiofrequency radiation. The results showed that paricalcitol administration could ameliorate ultrastructural changes in testicular tissue and increase antioxidant enzyme activity induced by 1800 MHz RFR exposure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Samira Souffi, Julie Lameth, Quentin Gaucher, Delia Arnaud-Cormos, Philippe Leveque, Jean-Marc Edeline, Michel Mallat
Summary: The study examined the effects of exposing rats to a 4G LTE-1800 MHz electromagnetic field (EMF) and found that it altered the processing of acoustic stimuli in the primary auditory cortex (ACx).
SCIENTIFIC REPORTS
(2022)
Review
Environmental Sciences
Blanka Pophof, Bernd Henschenmacher, Daniel R. Kattnig, Jens Kuhne, Alain Vian, Gunde Ziegelberger
Summary: This report summarizes the effects of anthropogenic radiofrequency electromagnetic fields with frequencies above 100 MHz on flora and fauna. These fields are common and come from terrestrial radio and TV broadcasting, mobile communication, wireless internet networks, and radar technologies. The effects on flora, fauna, and ecosystems are not well studied, but there is no scientific evidence of adverse effects from exposure to low-level anthropogenic radiofrequency fields in this frequency range. Further studies on plants and animals are recommended due to the scarcity of appropriate field studies.
Article
Environmental Sciences
Fernando Pareja-Pena, Antonio M. Burgos-Molina, Francisco Sendra-Portero, Miguel J. Ruiz-Gomez
Summary: Due to the increase in non-ionizing radiation emitting devices, concerns about their potential carcinogenicity have grown. Research suggests a possible causal relationship between RF-EMF exposure and brain tumor incidence, particularly with longer exposure and latency periods.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biology
Fenju Qin, Honglong Cao, Chuhan Feng, Tianyuan Zhu, Bingxu Zhu, Jie Zhang, Jian Tong, Hailong Pei
Summary: The study investigated the chronotoxicity of radiofrequency fields on pubertal testis development in mice by exposing them to RF in the morning and evening for three weeks. Pathological changes were observed, with decreased testicular weights, sperm production, and testosterone secretion. The study identified differentially expressed lncRNAs associated with morning and evening RF exposure, showing potential roles in the toxic effects of RF on testicular development.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Review
Environmental Sciences
Stefania Romeo, Olga Zeni, Anna Sannino, Susanna Lagorio, Mauro Biffoni, Maria Rosaria Scarfi
Summary: This article outlines a protocol for a systematic review of experimental studies investigating genotoxic effects induced by RF-EMF in in vitro cellular models. The study will follow guidelines from NTP-OHAT and will include experimental in vitro studies addressing the relationship between controlled exposures to RF-EMF and genotoxicity in mammalian cells.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell Biology
Ugo Cappucci, Assunta Maria Casale, Mirena Proietti, Fiorenzo Marinelli, Livio Giuliani, Lucia Piacentini
Summary: Exposure to artificial radio frequency electromagnetic fields (RF-EMFs) has increased in recent years, leading to a growing interest in understanding their biological impact. This study investigated the non-thermal effects of low-level indoor RF-EMF exposure from WiFi wireless technologies on Drosophila melanogaster. The results showed that WiFi radiation caused chromatin decondensation and loss of epigenetic silencing in both germinal and neural tissues, as well as accumulation of reactive oxygen species, genomic instability, and behavioral abnormalities. Additionally, WiFi radiation synergized with Ras(V12) to promote tumor progression and invasion.
Article
Microbiology
Mayura Veerana, Nan-Nan Yu, Si-Jin Bae, Ikhwan Kim, Eun-Seong Kim, Wirinthip Ketya, Hak-Yong Lee, Nam-Young Kim, Gyungsoon Park
Summary: This study demonstrates that exposure to a specific radio-frequency electromagnetic field can enhance the production of the enzyme alpha-amylase in a filamentous fungus, leading to increased protein concentration and activity. The exposure also affects the intracellular calcium level and transcription of genes involved in protein cellular trafficking.
Article
Chemistry, Physical
Marta Multigner, Irene Morales, Marta Munoz, Victoria Bonache, Fernando Giacomone, Patricia de la Presa, Rosario Benavente, Belen Torres, Diego Mantovani, Joaquin Rams
Summary: In this study, magnetic nanoparticles were used to enhance the properties of polylactic acid, with the aim of modifying the polymer structure by heating the reinforcing MNPs under radiofrequency electromagnetic fields. The nanocomposites showed increased crystallinity, hardness, and elastic modulus with EMF treatment.
Article
Environmental Sciences
Gang Yu, Yabing Zhu, Chao Song, Liang Chen, Zeping Tang, Tianpeng Wu
Summary: A study on rats exposed to 2605 MHz RF-EMR found that short-term exposure did not cause significant damage to fertility but increased testosterone and ZIP9 levels in Sertoli cells. These results contribute to a better understanding of the time-dependent reproductive toxicity of 2605 MHz RF-EMR.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Environmental Sciences
Raquel Ramirez-Vazquez, Isabel Escobar, Guy A. E. Vandenbosch, Francisco Vargas, David A. Caceres-Monllor, Enrique Arribas
Summary: Over the past 25 years, the number of radiofrequency sources has increased due to the global popularity of smartphones. This study reviewed and evaluated measured studies on personal exposure to RF-EMF, using specific criteria and guidelines. A total of 56 publications between 1998 and 2021 were examined, and different measurement methodologies were highlighted. The findings confirm that RF-EMF exposure levels are below the maximum guidelines established by ICNIRP.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Biomedical
Hazael Montanaro, Cristina Pasquinelli, Hyunjoo J. Lee, Hyunggug Kim, Hartwig R. Siebner, Niels Kuster, Axel Thielscher, Esra Neufeld
Summary: The study highlights the importance of properly modeling skull heterogeneity and structure, as well as accurately reproducing transducer positions. Results show potential issues when translating modeling approaches across clinical sites without proper standardization or recalibration of imaging and modeling parameters.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biology
Andreas Christ, Adrian Aeschbacher, Fereshteh Rouholahnejad, Theodoros Samaras, Bernadetta Tarigan, Niels Kuster
Summary: Recent theoretical studies above 6 GHz used generic layered skin models and new experimental phantoms were proposed to simulate impedance matching effects. Skin model verification compared S-11 reflection coefficients with measurements from human volunteers, showing dependency on SCL thickness but not on sex. Phantom material mimics SCL effects with deviations less than 0.85 dB, proving layered phantoms suitability in representing skin electromagnetic properties.
BIOELECTROMAGNETICS
(2021)
Article
Biology
Theodoros Samaras, Andreas Christ, Niels Kuster
Summary: New dosimetric quantities, specifically for frequencies above 6 GHz, are being introduced into exposure guidelines and safety standards, requiring the development of new experimental assessment procedures. By approximating the peak spatial-average absorbed power density using existing data and algorithms, compliance with the latest safety guidelines can be accurately determined. The expansion of dosimetric probes, phantoms, and procedures for frequencies above 10 GHz is planned for future projects.
BIOELECTROMAGNETICS
(2021)
Article
Oncology
Redi Poni, Esra Neufeld, Myles Capstick, Stephan Bodis, Theodoros Samaras, Niels Kuster
Summary: This study investigates the feasibility of electrical impedance tomography (EIT) as a low-cost, noninvasive technique for hyperthermia treatment monitoring. Through simulation, it was shown that EIT can provide accurate real-time monitoring capabilities and potentially be adapted for clinical use, highlighting its cost-effectiveness and noninvasiveness.
Article
Multidisciplinary Sciences
Theo Lemaire, Elena Vicari, Esra Neufeld, Niels Kuster, Silvestro Micera
Summary: The study shows that Low-Intensity Focused Ultrasound Stimulation (LIFUS) can selectively recruit different types of axons in neuron models by engaging membrane mechanoelectrical coupling, allowing for simultaneous and independent modulation of activity. This theoretical finding opens up opportunities for peripheral neuromodulation currently not achievable by electrical stimulation.
Article
Biochemistry & Molecular Biology
Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawa Kinany, Marina D'Ercole, Aurelie Paley, Nicolas Hankov, Camille Varescon, Laura McCracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Lea Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moira Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien van den Keybus, Gregoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis A. T. van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri van de Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien B. Wagner, Jocelyne Bloch, Gregoire Courtine
Summary: Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking ability in people with spinal cord injury. Using a computational framework and software, activity-specific stimulation programs allowed patients to perform various motor activities within a day. Neurorehabilitation significantly improved patients' everyday mobility.
Article
Biochemical Research Methods
Eline De Borre, Wout Joseph, Reza Aminzadeh, Pie Mueller, Matthieu N. Boone, Ivan Josipovic, Sina Hashemizadeh, Niels Kuster, Sven Kuehn, Arno Thielens
Summary: The study used Finite Difference Time Domain (FDTD) simulations to investigate the impact of RF exposure on A. aegypti mosquitoes between 2 and 240 GHz, showing an increase in absorbed power with increasing frequency up to 90 GHz, reaching a maximum between 90 and 120 GHz. This suggests that higher frequencies in 5G technology may lead to increased absorbed power and potential dielectric heating of insects.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oncology
Redi Poni, Esra Neufeld, Myles Capstick, Stephan Bodis, Niels Kuster
Summary: A novel optimization scheme was proposed to suppress hotspots and maximize tumor heating homogeneity, leading to reduced toxicity and potential recurrence. The scheme showed promising results in reducing peak temperature and hotspot volume in healthy tissue while maintaining or improving tumor heating uniformity.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Computer Science, Hardware & Architecture
German Castellanos, Simon De Gheselle, Luc Martens, Niels Kuster, Wout Joseph, Margot Deruyck, Sven Kuehn
Summary: This paper evaluates the impact of different 5G network topologies on human exposure, mobile communication quality, and sustainability. The findings indicate that UL exposure in a 5G network is ten times larger than DL exposure, and as traffic capacity increases, DL exposure increases by 36% on average while UL exposure decreases by up to 75%. Additionally, the study suggests that targeting only outdoor coverage can reduce DL exposure by a factor of 10. In conclusion, the ideal network should use 5G MaMIMO and be optimized for both UL and DL exposure.
Article
Engineering, Electrical & Electronic
Kristian S. Cujia, Arya Fallahi, Sylvain Reboux, Niels Kuster
Summary: Exposure assessment of wireless devices operating at >= 6 GHz requires accurate power density measurement. Existing methods are unsuitable for curved surfaces and closer distances. We propose a method based on sparse phaseless electric field measurements and multiple-multipole expansion for accurate evaluation in all field regions.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2022)
Article
Engineering, Biomedical
Andreas Spiegelberg, Andrea Boraschi, Fariba Karimi, Myles Capstick, Arya Fallahi, Esra Neufeld, Niels Kuster, Vartan Kurtcuoglu
Summary: The study developed a device and electrodes for noninvasive measurement of periodic changes in the dielectric properties of the human head. Signals obtained from healthy volunteers showed characteristic cardiac and respiratory modulations. Reduction of end-tidal CO2 through hyperventilation resulted in a decrease in the signal amplitude associated with cardiovascular action. The study suggests that noninvasive capacitive acquisition of changes in the dielectric properties of the head could be used to derive surrogates of craniospinal compliance.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Andrea Boraschi, Andreas Spiegelberg, Fariba Karimi, Kevin Graf, Arya Fallahi, Esra Neufeld, Niels Kuster, Vartan Kurtcuoglu
Summary: The study found that changes in body position can affect the distribution of cerebrospinal fluid and cause dynamic changes in the head's dielectric properties. These changes can be reflected in a noninvasive signal and used to derive the compliance of the craniospinal system.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tolga Goren, Sylvain Reboux, Silvia Farcito, Bryn Lloyd, Niels Kuster
Summary: This study investigates the impact of different head extent definitions on maximum RF exposure, revealing increased uncertainty in safety assessments.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Arya Fallahi, Sina Hashemizadeh, Niels Kuster
Summary: Using an open-ended coaxial probe and VNA is a common technique for noninvasive and broadband measurement of dielectric permittivity. The method is widely used for characterizing bulk materials, liquids, and thin sheet material samples. Limitations of the method in high-frequency regime and with thin sheet samples made of low-loss materials are mainly caused by imperfect contact between the probe and the sample.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aiping Yao, Tolga Goren, Theodoros Samaras, Niels Kuster, Wolfgang Kainz
Summary: This study evaluates the potential additional risks of broken and abandoned leads in RF-induced heating of AIMD during MR examinations. Results show that the enhancement of deposited lead-tip power for broken leads compared to intact leads can be significantly higher in different scenarios. Presence of nearby intact or broken wires can reduce this enhancement factor, highlighting the importance of considering lead design and clinical routing when assessing risks for MR examinations.
MAGNETIC RESONANCE IN MEDICINE
(2021)