Article
Pharmacology & Pharmacy
Paulina Czechowicz, Damian Neubauer, Joanna Nowicka, Wojciech Kamysz, Grazyna Gosciniak
Summary: The study found that cyclic analogs of ultrashort cationic lipopeptides exhibited enhanced antifungal activity against vaginal candidiasis compared to their linear analogs. Additionally, a synergistic effect was observed when linear lipopeptides were combined with fluconazole, leading to decreased minimum inhibitory concentrations. Further in vivo studies are needed to confirm the benefits of combination therapy using USCLs and fluconazole at low non-toxic concentrations.
Article
Infectious Diseases
Jie Peng, Xuming Liu, Qiangsheng Lu, Lvfeng Yuan, Wanyou Xu, Hecheng Zhang, Haoyue Zang
Summary: This study investigated the antibacterial effects of five different molecular side chain length lipopeptides on Staphylococcus aureus. Three lipopeptides showed strong antibacterial properties, with C16KGGK having excellent antibacterial action within the safe concentration range and therapeutic influence on Staphylococcus aureus-induced mastitis in mice.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Xiaogao Jin, Yanlin Wang
Summary: The study revealed that globular adiponectin induced the production of inflammatory cytokines in Raw 264.7 cells, while full-length adiponectin promoted macrophage migration.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Ye Hu, Xin Wang, Jiaying Song, Jiacheng Wu, Jia Xu, Yangyang Chai, Yuanyuan Ding, Bingjing Wang, Chunmei Wang, Yong Zhao, Zhongyang Shen, Xiaoqing Xu, Xuetao Cao
Summary: The transcription factor IRF3 plays a critical role in inducing antiviral type I interferon (IFN-I) production. The epigenetic remodelers ARID1A and NSD2 have been identified as key regulators in promoting IFN-I expression by enhancing chromatin accessibility of IRF3 at the Ifn-I promoters. This study provides insight into the crosstalk between chromatin remodeling, histone modification, and transcription factors in the epigenetic regulation of antiviral innate immunity.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Iwona Karwaciak, Anna Salkowska, Kaja Karas, Jaroslaw Dastych, Marcin Ratajewski
Summary: The COVID-19 pandemic caused by the new coronavirus SARS-CoV-2 has resulted in over 1.5 million deaths worldwide, with varying disease manifestations. Research has found that SARS-CoV-2 proteins can induce the production of IL-6 in human cells, potentially impacting immune responses and leading to cytokine storms.
Article
Chemistry, Multidisciplinary
Ramoncito Luis B. de Boda, Carl Angelo M. Caluag, Rachelle Anne S. Dante, Art Gersun J. Petate, Hermie Patrice T. Candaza, Windell L. Rivera, Sonia D. Jacinto, Portia Mahal G. Sabido
Summary: A series of novel lipopeptides with antimicrobial and anticancer activity have been reported, some of which show low toxicity to normal cells and selectivity towards microbial and cancer cells. These compounds have the potential as promising therapeutic agents.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2021)
Article
Agronomy
Karuppiah Vijay, Saqib Hassan, Muthusamy Govarthanan, Thangavel Kavitha
Summary: Discovery of lipopeptides from tomato rhizobacterium as effective antagonists to Fusarium wilt and inducers of plant systemic resistance. The lipopeptides exhibited mild biosurfactant properties and were chemically characterized. They showed broad spectrum of antifungal action against virulent Fusarium spp. and Sarocladium sp. This study highlights the potential of cultivable rhizobacteria and their lipopeptides as promising tools for disease management in agriculture.
Article
Medicine, Research & Experimental
Katsunori Endo, Rina Matsui, Takuya Asami, Toko Sawa, Akane Nakashima, Yuuri Tanaka, Hidefumi Makabe, Sachi Tanaka
Summary: PCB2DG from grape seeds suppresses the production of IL-17, TNF-alpha, IL-1 beta, and IL-6 by modulating transcription factors expression and cytokine secretion, providing a novel mechanism for the immunosuppressive effects of polyphenols.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Zaigham Abbas Rizvi, Rajdeep Dalal, Srikanth Sadhu, Yashwant Kumar, Shakti Kumar, Sonu Kumar Gupta, Manas Ranjan Tripathy, Deepak Kumar Rathore, Amit Awasthi
Summary: High-salt diet modulates tumor immunity by regulating gut microbiome, inducing NK cell-dependent immune response that inhibits tumor growth.
Article
Chemistry, Inorganic & Nuclear
Sayak Gupta, Jessica M. Vandevord, Lauren M. Loftus, Nicholas Toupin, Malik H. Al-Afyouni, Thomas N. Rohrabaugh, Claudia Turro, Jeremy J. Kodanko
Summary: The synthesis, chemical and biological characterization of seven Ru(II) polypyridyl complexes containing acetylacetonate (acac) ligands were studied. The compounds showed a range of cytotoxicities and selectivity in cancer and normal cell lines. Lipophilicity was found to have a moderate linear correlation with toxicities, and some Ru-acac compounds were found to induce apoptosis in MDA-MB-231 cells.
INORGANIC CHEMISTRY
(2021)
Article
Infectious Diseases
Oktawian Stachurski, Damian Neubauer, Aleksandra Walewska, Emilia Ilowska, Marta Bauer, Sylwia Bartoszewska, Karol Sikora, Aleksandra Hac, Dariusz Wyrzykowski, Adam Prahl, Wojciech Kamysz, Emilia Sikorska
Summary: This study investigates short cationic antimicrobial lipopeptides with a high propensity to fibrillate, which exhibit high activity and stability on bacterial membranes, and low cytotoxicity against human cells. The findings suggest that monomers are the main active form and the target of action of the lipopeptides is the bacterial membrane.
Article
Immunology
Spyridon Makris, Cecilia Johansson
Summary: Innate immune responses are crucial for protecting the neonatal lung, and neonatal lungs respond differently to various innate immune stimuli compared to adult lungs. Specifically, they show a weaker response to respiratory syncytial virus (RSV) but a stronger response to R848 and influenza virus, possibly due to higher levels of cAMP and enhanced responsiveness to extracellular adenosine. These findings have implications for the development of vaccine adjuvants for neonates.
MUCOSAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paulina Czechowicz, Joanna Nowicka, Damian Neubauer, Grzegorz Chodaczek, Pawel Krzyzek, Grazyna Gosciniak
Summary: In recent years, there has been a growing interest in fungal infections, including vulvovaginal candidiasis (VVC). However, the etiology of this infection remains unexplained, and the role of asymptomatic vaginal Candida colonization is still not clear. Standard methods of determining drug susceptibility may not accurately predict clinical effectiveness, leading to treatment failures and relapse rates. This study aimed to verify the previous in vitro results using a newly developed ex vivo model and to determine the effectiveness of selected ultrashort cyclic lipopeptides (USCLs) and their combinations with fluconazole against Candida biofilms on the vaginal epithelium. The results showed that the tested substances were ineffective in eradicating biofilms ex vivo, but combination therapy showed promising results. The compatibility between different testing methods needs further investigation to improve the understanding and treatment of VVC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Niranjala Gajanayaka, Simon Xin Min Dong, Hamza Ali, Salma Iqbal, Ananda Mookerjee, David A. Lawton, Ramon Edwin Caballero, Edana Cassol, Donald William Cameron, Jonathan B. Angel, Angela M. Crawley, Ashok Kumar
Summary: IFN-γ produced by M1 macrophages stimulated by IFN-gamma and IL-12/IL-18 plays a crucial role in controlling pathogens. The TLR-4-induced IFN-gamma production in M1 macrophages is regulated by the activation of multiple signaling pathways, suggesting potential therapeutic targets for inflammation and macrophage-mediated diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Xianzhe Zhou, Guishan Jin, Junwen Zhang, Fusheng Liu
Summary: As an important part of the glioma immune microenvironment, glioma-associated macrophages (GAMs) play crucial roles in tumor cell resistance to chemotherapy and radiotherapy as well as glioma pathogenesis. Research on GAM polarization and mechanisms of recruitment in the tumor microenvironment has been increasing. Suppressing GAMs at their source is likely to yield better therapeutic outcomes. This article summarizes the origin and recruitment mechanism of GAMs, as well as the therapeutic implications of inhibiting GAMs, aiming to facilitate future glioma-related research and the development of more effective treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Anthropology
A. B. Scott, K. Y. Choi, N. Mookherjee, R. D. Hoppa, L. A. Larcombe
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2016)
Article
Cell Biology
Mahadevappa Hemshekhar, Vidyanand Anaparti, Carol Hitchon, Neeloffer Mookherjee
MEDIATORS OF INFLAMMATION
(2017)
Letter
Critical Care Medicine
Hadeesha Piyadasa, Mahadevappa Hemshekhar, Christopher Carlsten, Neeloffer Mookherjee
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Respiratory System
Hadeesha Piyadasa, Mahadevappa Hemshekhar, Anthony Altieri, Sujata Basu, Anne M. van der Does, Andrew J. Halayko, Pieter S. Hiemstra, Neeloffer Mookherjee
Article
Rheumatology
Vidyanand Anaparti, Prasoon Agarwal, Irene Smolik, Neeloffer Mookherjee, Hani El-Gabalawy
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Catlin Semple, Ka-Yee Grace Choi, Andrea Kroeker, Lizette Denechezhe, Pamela Orr, Neeloffer Mookherjee, Linda Larcombe
SCIENTIFIC REPORTS
(2019)
Review
Biotechnology & Applied Microbiology
Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson
NATURE REVIEWS DRUG DISCOVERY
(2020)
Article
Immunology
Mahadevappa Hemshekhar, Hadeesha Piyadasa, Dina Mostafa, Leola N. Y. Chow, Andrew J. Halayko, Neeloffer Mookherjee
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Hadeesha Piyadasa, Dylan Lloyd, Amy H. Y. Lee, Anthony Altieri, Mahadevappa Hemshekhar, Natasha Osawa, Sujata Basu, Travis Blimkie, Reza Falsafi, Andrew J. Halayko, Robert E. W. Hancock, Neeloffer Mookherjee
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Thomas H. Mahood, Christopher D. Pascoe, Tobias K. Karakach, Aruni Jha, Sujata Basu, Peyman Ezzati, Victor Spicer, Neeloffer Mookherjee, Andrew J. Halayko
Summary: Analysis of proteomes from lung tissues and BALF of allergen-challenged mice revealed greater diversity in proteins between lung tissues and BALF compared to changes induced by allergen challenge. Biological pathways enriched after allergen exposure were compartment-dependent, with lung tissues showing innate immune responses and oxidative stress, and BALF showing changes in metabolism. Integration of proteomes from different compartments highlighted redox pathways and new proteins that may mediate interactions between lung tissue and BALF after allergen challenge.
Article
Chemistry, Medicinal
Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Dylan Lloyd, Anthony Altieri, Sujata Basu, Oleg Krokhin, Andrew J. Halayko, Neeloffer Mookherjee
Summary: Research demonstrates the importance of the tryptophan (W8) in the central hydrophobic region of IDR-1002 for its immunomodulatory activities in both murine and human models. This study provides insights for the design of targeted IDR peptides with specific impact on immunomodulation and respiratory diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Neeloffer Mookherjee, Min Hyung Ryu, Mahadevappa Hemshekhar, Juma Orach, Victor Spicer, Christopher Carlsten
Summary: This study details the impact of traffic-related air pollution on the human plasma proteome. It identifies specific proteins related to atherosclerosis that increase in concentration as the level of traffic-related air pollution increases.
ENVIRONMENTAL RESEARCH
(2022)
Article
Respiratory System
Juma Orach, Christopher Francis Rider, Agnes Che Yan Yuen, Carley Schwartz, Neeloffer Mookherjee, Christopher Carlsten
Summary: In this study, the concentration-response relationship between airway health measures and diesel exhaust exposure was investigated. The results showed that diesel exhaust exposure led to a concentration-dependent increase in airway inflammation, indicating that it may be a sensitive marker of acute inflammatory response in the airways. Furthermore, this study documented the concentration-response estimates of particulate matter <2.5 μm in aerodynamic diameter at exposure levels commonly experienced in the community and occupational settings.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Rheumatology
Mahadevappa Hemshekhar, Vidyanand Anaparti, Hani El-Gabalawy, Neeloffer Mookherjee
Summary: The combination of highly bioavailable curcumin, vitamin D-3, and omega-3 fatty acids significantly delays and reduces the development of collagen-induced arthritis (CIA). This study suggests a rationale for systematically evaluating these widely available supplements in individuals at risk for developing rheumatoid arthritis.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Rheumatology
Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Victor Spicer, Neeloffer Mookherjee, Hani El-Gabalawy
ARTHRITIS RESEARCH & THERAPY
(2017)