Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
June Seok Heo, Sinyoung Kim
Summary: This study found that human adipose mesenchymal stem cell-derived exosomes have anti-inflammatory and pro-angiogenic effects. Exosomes inhibit inflammation by activating ROCK1 and PTEN expression, and promote angiogenesis by releasing miR-132 and miR-146a.
SCIENTIFIC REPORTS
(2022)
Article
Acoustics
Arzu Hizay, Umut Ozsoy, Kamil Savas, Sezin Yakut-Uzuner, Ozlem Ozbey, Simla Su Akkan, Pinar Bahsi
Summary: This study aimed to investigate the effect of ultrasound treatment on the expression of vascular endothelial growth factor (VEGF), its receptors, and new vessel formation after facial nerve injury. The results showed that ultrasound treatment significantly increased the levels of VEGF, VEGFR1, VEGFR2, and CD31, promoting facial nerve regeneration and functional improvement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Hematology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell-cell contact is established.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Dong Cho, Nguyen Thi Thanh Nhan, Christopher Zhou, Kayeman Tu, Tara Nguyen, Nicolene A. Sarich, Kaori H. Yamada
Summary: Excessive VEGF-A signaling induces vascular leakage and angiogenesis. KIF13B-mediated recycling of internalized VEGFR2 through Rab11-positive recycling vesicle regulates endothelial permeability. Inhibition of KIF13B-mediated VEGFR2 trafficking mitigates vascular leakage in models of blinding eye disease wet AMD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Multidisciplinary Sciences
Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Yu
Summary: Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties. This study found that PS18 has neuroprotective effects in cellular and animal models of Parkinson's disease, possibly through anti-endoplasmic reticulum stress mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Ram Kuwar, Xuejun Wen, Ning Zhang, Dong Sun
Summary: This study investigated the role of integrins in promoting adhesion, growth, development, and vascular-like network formation of rat primary brain microvascular endothelial cells. By using an integrin-binding array platform, specific types of integrins and their binding peptides were identified. Furthermore, a 3D hydrogel culture system functionalized with these binding peptides promoted robust growth and lumenized microvascular-like network formation of brain microvascular endothelial cells.
NEURAL REGENERATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Rou-Gang Xie, Wen-Guang Chu, Da-Lu Liu, Xu Wang, Sui-Bin Ma, Fei Wang, Fu-Dong Wang, Zhen Lin, Wen-Bin Wu, Na Lu, Ying-Ying Liu, Wen-Juan Han, Hui Zhang, Zhan-Tao Bai, San-Jue Hu, Hui-Ren Tao, Thomas Kuner, Xu Zhang, Rohini Kuner, Sheng-Xi Wu, Ceng Luo
Summary: This study reveals the regulatory role of presynaptic NMDARs in spinal nociceptor terminals in pain transmission. It also uncovers the state-dependent modulation mechanism of presynaptic NMDARs on presynaptic plasticity and pain sensitivity.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Nele Warmke, Fiona Platt, Alexander F. Bruns, Claire H. Ozber, Natalie J. Haywood, Yilizila Abudushalamu, Charles Slater, Victoria Palin, Piruthivi Sukumar, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, Mark T. Kearney, Kathryn J. Griffin, Richard M. Cubbon
Summary: In this study, pericyte insulin signaling was found to promote angiopoietin-1 secretion and endothelial Tie2 signaling. Disruption of this pathway led to excessive vascular sprouting and venous plexus abnormalities, mimicking diabetic retinopathy characteristics. Future research should focus on evaluating the role of pericyte insulin signaling in this disease.
Article
Endocrinology & Metabolism
Nele Warmke, Fiona Platt, Alexander F. Bruns, Claire H. Ozber, Natalie J. Haywood, Yilizila Abudushalamu, Charles Slater, Victoria Palin, Piruthivi Sukumar, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, Mark T. Kearney, Kathryn J. Griffin, Richard M. Cubbon
Summary: Pericytes play a crucial role in regulating vascular development and stability, with dysfunction potentially contributing to diabetic retinopathy. Knockout of insulin receptors in pericytes resulted in abnormal vascular development, indicating the importance of insulin signaling in promoting angiopoietin-1 secretion and endothelial Tie2 signaling.
Article
Multidisciplinary Sciences
Yoshiya Asano, Daisuke Okano, Michiya Matsusaki, Tetsuro Watabe, Yasuhiro Yoshimatsu, Mitsuru Akashi, Hiroshi Shimoda
Summary: In this study, an artificial vascular tissue constructed by human adipose tissue-derived stromal cells (hASCs) and HUVECs (ASCVT) showed higher vascular network density and expression of angiogenesis-related factors. Subcutaneous transplantation of ASCVT into nude mice resulted in the formation of functional vessel networks within 4 weeks.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Anna Tylutka, Barbara Morawin, Edyta Wawrzyniak-Gramacka, Eryk Wacka, Wiktoria Nowicka, Jaroslaw Hiczkiewicz, Agnieszka Zembron-Lacny
Summary: This study reveals the association between immunosenescence-related disproportion in T lymphocytes and endothelial dysfunction, highlighting its potential impact on vascular aging. Assessing the inflammatory-immune profile could help better predict and prevent vascular diseases associated with old age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Silvia Silva-Hucha, Genova Carrero-Rojas, Maria Estrella Fernandez de Sevilla, Beatriz Benitez-Temino, Maria America Davis-Lopez de Carrizosa, Angel M. Pastor, Sara Morcuende
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Cell Biology
Genova Carrero-Rojas, Beatriz Benitez-Temino, Angel M. Pastor, Ma America Davis Lopez de Carrizosa
Review
Biochemistry & Molecular Biology
Silvia Silva-Hucha, Angel M. Pastor, Sara Morcuende
Summary: VEGF, initially known as a potent angiogenic factor, also plays a crucial role as a neuroprotective factor in the nervous system. A deficit of VEGF is related to motoneuronal degeneration, like in ALS. Oculomotor system motoneurons show higher levels of VEGF and are more resistant to injury and neurodegenerative diseases compared to other motoneurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alejandro Herrera, Sara Morcuende, Rocio Talaveron, Beatriz Benitez-Temino, Angel M. Pastor, Esperanza R. Matarredona
Summary: The general blockade of purinergic receptors with suramin has been found to have a positive impact on the survival rate of neural progenitor cells (NPCs), increasing NPC number by reducing apoptosis and affecting the expression of various proteins, providing a potential drug therapy approach for improving NPC survival before transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Genova Carrero-Rojas, Rosendo G. Hernandez, Roland Blumer, Rosa R. de la Cruz, Angel M. Pastor
Summary: The study found that both MIF and SIF motoneurons are involved in various types of eye movements, but MIF motoneurons have lower firing frequencies, are recruited earlier, and show lower sensitivity to eye position and velocity compared to SIF motoneurons. MIF motoneurons are also smaller in size, have longer antidromic latencies, and lower synaptic coverage than SIF motoneurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Paula M. Calvo, Rosendo G. Hernandez, Rosa R. de la Cruz, Angel M. Pastor
Summary: VEGF is a substance that has both angiogenic and neurotrophic activities. This study found that VEGF deprivation through retrograde transport affected the physiology of intact abducens motoneurons, causing changes in firing pattern, eye position, and eye velocity sensitivity, as well as a reduction in the density of afferent synaptic terminals. These findings demonstrate the essential role of retrogradely delivered VEGF in motoneuronal synaptic drive and discharge activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Clinical Neurology
Paula M. Calvo, Rosendo G. Hernandez, Angel M. Pastor, Rosa R. de la Cruz
Summary: VEGF deficiency is associated with neurodegenerative diseases, and treatment with VEGF can improve motor function and reduce motoneuronal degeneration. Low plasma levels of VEGF are also associated with ALS.
Article
Anatomy & Morphology
Paula M. Calvo, Rosa R. de la Cruz, Angel M. Pastor, Francisco J. Alvarez
Summary: The muscle-derived factor VEGF can upregulate KCC2 expression in axotomized abducens motoneurons, improving synaptic inhibition. This is the first report of lack of KCC2 regulation in a motoneuron type after injury, proposing a role for VEGF in KCC2 regulation and demonstrating the link between KCC2 and synaptic inhibition in awake, behaving animals.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Anatomy & Morphology
Rosendo G. Hernandez, Beatriz Benitez-Temino, Rosa R. de la Cruz, Angel M. Pastor
Summary: In this study, the discharge activity of premotor neurons and eye movements were recorded simultaneously in a chronic cat preparation. The results showed that ABD Ints had a high correlation with eye movements, exhibiting sensitivity to eye position and velocity. ATD neurons also discharged in relation to eye movements but with lower sensitivity. Interestingly, ATD neurons had a lower recruitment threshold compared to ABD Ints and played a significant role in facilitating ABD Int signal transmission onto medial rectus motoneurons.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Ophthalmology
Roland Blumer, Johannes Streicher, Genova Carrero-Rojas, Paula M. Calvo, Rosa R. de la Cruz, Angel M. Pastor
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)