Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes

Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53

(2012) Ming-Fu Chiang et al.   BIOMEDICINE & PHARMACOTHERAPY

PI3King on MYCN to Improve Neuroblastoma Therapeutics

(2012) Michael D. Hogarty et al.   CANCER CELL

The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma

(2012) Teeara Berry et al.   CANCER CELL

Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

(2012) Shizhen Zhu et al.   CANCER CELL

Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma

(2012) Stefano Monti et al.   CANCER CELL

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

(2012) Maria Meehan et al.   Molecular Cancer

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice

(2012) L. C. Heukamp et al.   Science Translational Medicine

WWOXinduces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721

(2012) Ben-Shun Hu   WORLD JOURNAL OF GASTROENTEROLOGY

Regulatory Mechanisms of Tumor Suppressor P16INK4Aand Their Relevance to Cancer

(2011) Junan Li et al.   BIOCHEMISTRY

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

FAS-Associated Factor 1 (FAF1): Diverse functions and implications for oncogenesis

(2011) Craig W. Menges et al.   CELL CYCLE

Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis

(2011) Raghu Gogada et al.   CELL CYCLE

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

(2011) T. Reiff et al.   DEVELOPMENT

The relationship between RGS5 expression and cancer differentiation and metastasis in non-small cell lung cancer

(2011) Guichun Huang et al.   JOURNAL OF SURGICAL ONCOLOGY

Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

(2011) Åslaug Helland et al.   PLoS One

Genetically engineered murine models – Contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma

(2011) Louis Chesler et al.   SEMINARS IN CANCER BIOLOGY

Emerging importance of ALK in neuroblastoma

(2011) Anna M. Azarova et al.   SEMINARS IN CANCER BIOLOGY

p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma

(2010) L. Chen et al.   CANCER RESEARCH

NF1 Is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease Outcome

(2010) Michael Hölzel et al.   CELL

Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q- Neuroblastoma

(2010) P. G. Buckley et al.   CLINICAL CANCER RESEARCH

Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification

(2010) S. De Brouwer et al.   CLINICAL CANCER RESEARCH

The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

(2010) Pieter Mestdagh et al.   MOLECULAR CELL

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

Myc proteins as therapeutic targets

(2010) W C Gustafson et al.   ONCOGENE

MYCN-regulated microRNAs repress estrogen receptor-  (ESR1) expression and neuronal differentiation in human neuroblastoma

(2010) J. Loven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anaplastic lymphoma kinase: signalling in development and disease

(2009) Ruth H. Palmer et al.   BIOCHEMICAL JOURNAL

Smoothing waves in array CGH tumor profiles

(2009) Mark A. van de Wiel et al.   BIOINFORMATICS

BioMart – biological queries made easy

(2009) Damian Smedley et al.   BMC GENOMICS

Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study

(2009) Miyoung Kim et al.   CANCER GENETICS AND CYTOGENETICS

The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog-Treated Cerebellar Neural Precursors

(2009) P. A. Northcott et al.   CANCER RESEARCH

Genetic risk factors for melanoma

(2009) Kathrine Damm Meyle et al.   HUMAN GENETICS

MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors

(2009) P Mestdagh et al.   ONCOGENE

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulator of G Protein Signaling 5: A New Player in Vascular Remodeling

(2009) Mitali Manzur et al.   TRENDS IN CARDIOVASCULAR MEDICINE

A novel and universal method for microRNA RT-qPCR data normalization

(2009) Pieter Mestdagh et al.   GENOME BIOLOGY

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

(2008) Helena Carén et al.   BIOCHEMICAL JOURNAL

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors; Four cases of homozygous deletions of the CDKN2A gene

(2008) Helena Caren et al.   BMC GENOMICS

Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma

(2008) J. J. Molenaar et al.   CANCER RESEARCH

ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

(2008) M. D. Hogarty et al.   CANCER RESEARCH

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Activating mutations in ALK provide a therapeutic target in neuroblastoma

(2008) Rani E. George et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

(2008) Isabelle Janoueix-Lerosey et al.   NATURE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA

(2008) Pieter Mestdagh et al.   NUCLEIC ACIDS RESEARCH

RTPrimerDB: the portal for real-time PCR primers and probes

(2008) S. Lefever et al.   NUCLEIC ACIDS RESEARCH

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

(2008) Frank Westermann et al.   GENOME BIOLOGY

MYCN regulates oncogenic MicroRNAs in neuroblastoma

(2007) Johannes H. Schulte et al.   INTERNATIONAL JOURNAL OF CANCER