New Details of HCV NS3/4A Proteinase Functionality Revealed by a High-Throughput Cleavage Assay

In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile

(2011) Morgan M. Martin et al.   BIOLOGICAL CHEMISTRY

Hepatitis C virus: How genetic variability affects pathobiology of disease

(2011) Kazuaki Chayama et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus

(2011) K. Morikawa et al.   JOURNAL OF VIRAL HEPATITIS

Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

(2011) Ann D Kwong et al.   NATURE BIOTECHNOLOGY

Mechanistic role of NS4A and substrate in the activation of HCV NS3 protease

(2011) Haimei Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor

(2010) Frank Bennett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

(2010) Margit Hagel et al.   Nature Chemical Biology

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS

High diversity of hepatitis C viral quasispecies is associated with early virological response in patients undergoing antiviral therapy

(2009) Xiaofeng Fan et al.   HEPATOLOGY

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Autocatalytic Activation of the Furin Zymogen Requires Removal of the Emerging Enzyme's N-Terminus from the Active Site

(2009) Katarzyna Gawlik et al.   PLoS One

Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3

(2009) V. Schregel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate whole human genome sequencing using reversible terminator chemistry

(2008) David R. Bentley et al.   NATURE