3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2

Novel Imidazol-1-ylmethyl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as Potent and Selective CYP11B1 Inhibitors for the Treatment of Cushing’s Syndrome

(2012) Lina Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer

(2012) Qingzhong Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors

(2012) Ashraf H. Abadi et al.   MedChemComm

Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives

(2011) Simon Lucas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of 1,3,5-trisubstituted 1,2,4-triazoles as CYP enzyme inhibitors

(2011) Yaseen A. Al-Soud et al.   TETRAHEDRON LETTERS

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases

(2011) Ulrike E. Hille et al.   ACS Medicinal Chemistry Letters

The Role of Fluorine Substitution in Biphenyl Methylene Imidazole-Type CYP17 Inhibitors for the Treatment of Prostate Carcinoma

(2010) Qingzhong Hu et al.   ChemMedChem

Isopropylidene Substitution Increases Activity and Selectivity of Biphenylmethylene 4-Pyridine Type CYP17 Inhibitors

(2010) Qingzhong Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replacement of Imidazolyl by Pyridyl in Biphenylmethylenes Results in Selective CYP17 and Dual CYP17/CYP11B1 Inhibitors for the Treatment of Prostate Cancer

(2010) Qingzhong Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of 1-Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2)

(2010) Luc Roumen et al.   JOURNAL OF MEDICINAL CHEMISTRY

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

(2010) Ulrike E. Hille et al.   ACS Medicinal Chemistry Letters

Steroidogenic cytochrome P450 (CYP) enzymes as drug targets: Combining substructures of known CYP inhibitors leads to compounds with different inhibitory profile

(2009) Ulrike E. Hille et al.   COMPTES RENDUS CHIMIE

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

(2009) Ulrike E. Hille et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CYP17 Inhibitors. Annulations of Additional Rings in Methylene Imidazole Substituted Biphenyls: Synthesis, Biological Evaluation and Molecular Modelling

(2008) Mariano A. E. Pinto-Bazurco Mendieta et al.   ARCHIV DER PHARMAZIE

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge

(2008) Qingzhong Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

(2008) P. Mulder et al.   EUROPEAN HEART JOURNAL

Synthesis, Biological Evaluation, and Molecular Modeling of Abiraterone Analogues: Novel CYP17 Inhibitors for the Treatment of Prostate Cancer

(2008) Mariano A. E. Pinto-Bazurco Mendieta et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1H-quinolin-2-one Derivatives

(2008) Simon Lucas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity

(2008) Ralf Heim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach

(2008) Simon Lucas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

(2007) Carsten Jagusch et al.   BIOORGANIC & MEDICINAL CHEMISTRY