The Role of Fluorine Substitution in Biphenyl Methylene Imidazole-Type CYP17 Inhibitors for the Treatment of Prostate Carcinoma

Steroidogenic cytochrome P450 (CYP) enzymes as drug targets: Combining substructures of known CYP inhibitors leads to compounds with different inhibitory profile

(2009) Ulrike E. Hille et al.   COMPTES RENDUS CHIMIE

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

(2009) Ulrike E. Hille et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

(2009) Emmanuel Bey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells

(2009) Patricia Kruchten et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

CYP17 Inhibitors. Annulations of Additional Rings in Methylene Imidazole Substituted Biphenyls: Synthesis, Biological Evaluation and Molecular Modelling

(2008) Mariano A. E. Pinto-Bazurco Mendieta et al.   ARCHIV DER PHARMAZIE

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge

(2008) Qingzhong Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors

(2008) Sabrina Castellano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cancer Statistics, 2008

(2008) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Aromatase Inhibitors for Breast Cancer: Proven Efficacy Across the Spectrum of Disease

(2008) Christina I. Herold et al.   Clinical Breast Cancer

Synthesis, Biological Evaluation, and Molecular Modeling of Abiraterone Analogues: Novel CYP17 Inhibitors for the Treatment of Prostate Cancer

(2008) Mariano A. E. Pinto-Bazurco Mendieta et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1H-quinolin-2-one Derivatives

(2008) Simon Lucas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity

(2008) Ralf Heim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach

(2008) Simon Lucas et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics

(2008) Sandrine Marchais-Oberwinkler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

(2008) Emmanuel Bey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases

(2008) Martin Frotscher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure

(2007) Carsten Jagusch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17

(2007) Mariano A.E. Pinto-Bazurco Mendieta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS