Article
Pharmacology & Pharmacy
Xiao-Hui Dong, Cheng Peng, Yu-Yi Zhang, Yu Jiang, Li-Jun Yang, Jia-Bei He, Xia Tao, Chuan Zhang, Alex F. Chen, He-Hui Xie
Summary: The study found that low-dose piperlongumine can enhance the angiogenic potential of EPCs and protect HFD-fed mice from cerebral ischemic injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Retraction
Cell Biology
Xing-Li Liu, Gang Wang, Wei Song, Wei-Xin Yang, Jian Hua, Liang Lyu
Summary: The article was retracted due to the publication of duplicated image elements in a different scientific context, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qunchao Ma, Ning Zhang, Yayu You, Jinyun Zhu, Zhaosheng Yu, Haibo Chen, Xiaojie Xie, Hong Yu
Summary: This study assessed the effect of CXCR4 expression in macrophages on angiogenesis in the ischemic hindlimb and found that specific CXCR4 deficiency in macrophages could attenuate inflammation and promote blood vessel formation.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wanqing Xie, Tingting Huang, Yunlu Guo, Yueman Zhang, Weijie Chen, Yan Li, Chen Chen, Peiying Li
Summary: Neutrophils play critical roles in the evolving of brain injuries following ischemic stroke. CAMP represents an important mediator that could promote post-stroke angiogenesis and neurological recovery in the late phase after stroke. CAMP peptide treatment could enhance angiogenesis-related gene expression and attenuate neurological deficits after stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y-C. Wu, N. Yu, C. A. Rivas, N. Mehrnia, A. Kantarci, T. E. Van Dyke
Summary: This study investigated the role of Resolvin E1 (RvE1) in dental pulp regeneration and its impact on infected pulps. The results showed that RvE1 promoted cell proliferation and differentiation, modulated inflammation resolution, reduced infection severity, and prevented apical periodontitis. RvE1 has the potential to be a novel therapeutic for treating endodontic diseases.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Neurosciences
Chao Zhou, Moxi Su, Ping Sun, Xuelian Tang, Ke-Jie Yin
Summary: Nitro-oleic acid may serve as a therapeutic agent for ischemic brain injury by preserving BBB integrity, reducing brain infarct size, improving sensorimotor functions, and inhibiting inflammation and cell infiltration induced by ischemia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Myles R. McCrary, Michael Q. Jiang, Kaleena Jesson, Xiaohuan Gu, Meghan T. Logun, Anika Wu, Nathan Gonsalves, Lohitash Karumbaiah, Shan Ping Yu, Ling Wei
Summary: Ischemic stroke is a major cause of illness and death, with limited treatment options. Neural progenitor cells have the potential to replace tissue lost to stroke, and biomaterial approaches can enhance their effectiveness. The immune response plays a crucial role in stroke pathogenesis and regeneration, and may interact with stem cell and biomaterial therapies.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao
Summary: Stroke is a major cause of death, with oxidative stress playing a key role. Celastrol has strong antioxidant properties, but its effect on oxidative reactions in cerebral ischemic-reperfusion injury (CIRI) is unclear. This study aimed to investigate the impact of celastrol on oxidative damage during CIRI and the underlying mechanisms. The findings revealed that celastrol reduced oxidative injury in CIRI by upregulating Nrf2. Celastrol directly bound to Nedd4, releasing Nrf2 in astrocytes, thus inhibiting Nrf2 degradation and reducing astrocytic ROS production. Celastrol also rescued neurons from damage and apoptosis by inhibiting oxidative stress and astrocyte activation.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Laughing Bear Torrez Dulgeroff, Miranda S. Oakley, Michal C. Tal, Ying Ying Yiu, Joy Q. He, Maia Shoham, Victoria Majam, Winter A. Okoth, Pallavi Malla, Sanjai Kumar, Irving L. Weissman
Summary: CD47 is an antiphagocytic signal that inhibits programmed cell removal of self. Blocking CD47 can significantly improve the therapeutic effect against malaria infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Yao-Hua Ma, Wen-Jing Deng, Zhi-Yi Luo, Jing Jing, Peng-Wei Pan, Yao-Bing Yao, Yan-Bo Fang, Jun-Fang Teng
Summary: MiR-29b plays a critical role in brain homeostasis and inhibiting its expression can reduce cell apoptosis and oxidative damage in ischemic stroke.
NEURAL REGENERATION RESEARCH
(2022)
Article
Pediatrics
John D. E. Barks, Yiqing Liu, Ian A. Dopp, Faye S. Silverstein
Summary: The study showed that AZ improves sensorimotor function, survival, brain tissue preservation, and composite scores in two neonatal rat models of inflammation-amplified HI brain injury. The benefits of AZ treatment increased with higher doses and decreased with longer initiation delays. The findings support further evaluation of AZ as a candidate treatment for neonatal neuroprotection, even with a 2-hour delay in initiation.
PEDIATRIC RESEARCH
(2022)
Article
Neurosciences
Petra Sucha, Zuzana Hermanova, Martina Chmelova, Denisa Kirdajova, Sara Camacho Garcia, Valeria Marchetti, Ivan Vorisek, Jana Tureckova, Eyar Shany, Daniel Jirak, Miroslava Anderova, Lydia Vargova
Summary: This study investigated the interaction between astrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4 (TRPV4) channels and their impact on brain injury after stroke. The results showed that deleting AQP4 or TRPV4 channels alone worsened the ischemic brain injury, while deleting both channels resulted in a smaller initial brain lesion but similar tissue damage in the later phase as compared to controls. The study suggests that the interplay between AQP4 and TRPV4 channels plays a critical role in neuronal and non-neuronal swelling after ischemic injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Rengong Zhuo, Zhengmao Song, Yun Wang, Maoshu Zhu, Feng Liu, Pingli Lin, Rong Rao, Yu Zhou, Yun Zhao, Zhongxiong Fan, Lishan Cui, Hongtao Liu, Jingwen Li, Ying Li, Han Guo, Cheng Fu Cai, Lichao Yang
Summary: This study reveals that OEA promotes angiogenesis, neurogenesis, and white matter repair after stroke, leading to improved motor function recovery.
PHYTOTHERAPY RESEARCH
(2023)
Review
Clinical Neurology
Antia Custodia, Alberto Ouro, Joao Sargento-Freitas, Marta Aramburu-Nunez, Juan Manuel Pias-Peleteiro, Pablo Hervella, Anna Rosell, Lino Ferreira, Jose Castillo, Daniel Romaus-Sanjurjo, Tomas Sobrino
Summary: Ischemic stroke is a common cause of death and disability in developed countries. Current therapeutic options are limited, so there is a need for novel treatments. Endothelial progenitor cells (EPCs) have been shown to repair damaged vessels and generate new ones. EPCs appear to be a promising target for stroke treatment, promoting re-endothelialization, angiogenesis, and vasculogenesis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Xiaoqing Yan, Yue Su, Xia Fan, Hui Chen, Zixian Lu, Zijuan Liu, Yingjian Li, Mei Yi, Guigui Zhang, Chunjie Gu, Kai Wang, Jiamin Wu, Da Sun, Yikai Zhang, Chi Zhang, Xiaozhen Dai, Chao Zheng
Summary: Liraglutide has the potential to improve endothelial progenitor cell (EPC) function and promote angiogenesis under diabetic conditions by activating the Nrf2 pathway.
Article
Cell Biology
Yuchen Li, Pei Wu, Jiaxing Dai, Tongyu Zhang, Ji Bihl, Chunlei Wang, Yao Liu, Huaizhang Shi
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)
Article
Cell Biology
Jinju Wang, Shuzhen Chen, Ji Bihl
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Yuchen Li, Yao Liu, Pei Wu, Yang Tian, Binbing Liu, Jinju Wang, Ji Bihl, Huaizhang Shi
Summary: Ferroptosis plays a key role in early brain injury (EBI) in SAH patients. The inhibitor Fer-1 shows neuroprotection by alleviating ferroptosis and potentially suppressing lipid peroxidation in EBI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Langni Liu, Katherine E. Fahy, Azeezat A. Awoyemi, Pariksha Thapa, Lisa E. Kelly, Jay Chen, Ji C. Bihl, David Cool, Yanfang Chen, Christine M. Rapp, R. Michael Johnson, Jeffrey B. Travers
JOURNAL OF IMMUNOLOGY
(2020)
Article
Genetics & Heredity
Elliott Hayden, Shuzhen Chen, Abagail Chumley, Chenyi Xia, Quan Zhong, Shulin Ju
G3-GENES GENOMES GENETICS
(2020)
Article
Clinical Neurology
Huiting Zhang, Qunwen Pan, Zi Xie, Yanyu Chen, Jinju Wang, Ji Bihl, Wangtao Zhong, Yanfang Chen, Bin Zhao, Xiaotang Ma
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Neurosciences
Jinju Wang, Hua Liu, Shuzhen Chen, Wenfeng Zhang, Yanfang Chen, Yi Yang
EXPERIMENTAL NEUROLOGY
(2020)
Article
Medicine, Research & Experimental
Liping Liu, Qinmao Ye, Langni Liu, Ji Chen Bihl, Yanfang Chen, Jing Liu, Qian Cheng
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao, Xiaotang Ma
STEM CELL RESEARCH & THERAPY
(2020)
Article
Neurosciences
Jinju Wang, Shuzhen Chen, Wenfeng Zhang, Yanfang Chen, Ji C. Bihl
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Article
Cell & Tissue Engineering
Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi, Ji Bihl
STEM CELL RESEARCH & THERAPY
(2020)
Article
Cell Biology
Jinju Wang, Venkata Polaki, Shuzhen Chen, Ji C. Bihl
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Review
Neurosciences
Sri Meghana Yerrapragada, Ji Chen Bihl
Summary: Adipose tissue-released exosomes play a modulatory role in the brain by transporting bioactive molecules, particularly miRNAs, and may serve as potential therapeutic targets for neurological disorders.
NEUROMOLECULAR MEDICINE
(2022)
Article
Cell & Tissue Engineering
Manasi Suchit Halurkar, Jinju Wang, Shuzhen Chen, Ji Chen Bihl
Summary: The study confirms that EPC-EXs can protect astrocytes from damage caused by HG and H/R, and miR-126 enriched EPC-EXs enhance their protective effects.
STEM CELL RESEARCH & THERAPY
(2022)