Review
Biochemistry & Molecular Biology
Julia E. M. Upton, Eyal Grunebaum, Gordon Sussman, Peter Vadas
Summary: Platelet-activating factor (PAF) plays a crucial role in multiple inflammatory conditions, contributing to platelet aggregation and activation as well as allergic and nonallergic inflammatory diseases. Recent research has highlighted its significance in various medical conditions, including severe pediatric anaphylaxis, blood-brain barrier permeability, reproduction, ocular diseases, and cardiovascular risk. The investigation of PAF as both a biomarker and therapeutic target continues to provide potential for targeted and effective treatments for inflammatory conditions.
Article
Cell Biology
Mary A. Smal, Brian A. Baldo
Summary: Experiments identified a fatty acid inhibitor in human saliva that can effectively inhibit PAF-induced platelet aggregation. The cis-unsaturated fatty acids showed strong inhibitory effects, especially on ADP-induced PA, suggesting a potential regulatory role in certain diseases.
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Soodeh Mahdian, Reihaneh Pirjani, Raha Favaedi, Monireh Movahedi, Ashraf Moini, Maryam Shahhoseini
Summary: The study compared the levels of aPL and PAF among RIF and fertile women, finding that Anti Cardiolipin antibody IgG levels were above normal in a small portion of RIF patients. Differences in the correlation of aPL and PAF levels in the two groups suggest that the same changes may have different effects on RIF and fertile women.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Cell Biology
Pu Rong, Jie-Li Wang, Angelina Angelova, Zakaria A. Almsherqi, Yuru Deng
Summary: This article explores the relationship between plasmalogens and Platelet-Activating Factor (PAF), suggesting the potential role of plasmalogenic analogs of PAF as modulators and PAF antagonists. The metabolic interconversion of these lipids is discussed as an important factor in preventing and relieving PAF-mediated inflammation, and the possibility of plasmalogen analogs as a new class of bioactive anti-inflammatory drugs is proposed. Additionally, the competition between PAF and its natural plasmalogenic analogs for binding to the PAF receptor is proposed as a mechanistic model and potential therapeutic perspective.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Filio Petsini, Agathi Ntzouvani, Maria Detopoulou, Vasiliki D. Papakonstantinou, Nick Kalogeropoulos, Elizabeth Fragopoulou, Tzortzis Nomikos, Meropi D. Kontogianni, Smaragdi Antonopoulou
Summary: Eating farmed fish fed with an olive-pomace enriched diet affects PAF metabolism and markers of inflammation and oxidative stress, but has similar effects to conventionally fed farmed fish.
Review
Endocrinology & Metabolism
Jeffrey B. Travers, Joyce G. Rohan, Ravi P. Sahu
Summary: PAF, a glycerophosphocholine lipid mediator, plays a crucial role in pathologic processes and can be transmitted through MVP to activate the PAF receptor and generate more PAF. Studying the PAF family of lipid mediators is essential for understanding the relationship among diverse cutaneous, cancerous, neurologic, and systemic pathologic processes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marie-Eve Tremblay, Zakaria A. Almsherqi, Yuru Deng
Summary: Fatty acids and phospholipids play essential roles in the structure and function of cell membranes. Recent research has focused on two subclasses of ether phospholipids, platelet activating factor (PAF) and its precursor plasmalogen, due to their association with several chronic inflammatory, neurodegenerative, and metabolic disorders. Inflammatory conditions often involve an excess of PAF or decreased levels of plasmalogens. The exact mechanisms of plasmalogens in inflammation are not yet fully understood. Anti-inflammatory responses are likely mediated by the plasmalogen signaling pathway, while pro-inflammatory responses involve the release of arachidonic acid from membrane phospholipids, particularly derived from the hydrolysis of plasmalogens. Changes in plasmalogen levels can affect cell membrane properties and impact signaling pathways involved in inflammatory cascades and immune responses. Plasmalogen replacement therapy shows promise as an anti-inflammatory strategy for treating chronic diseases with an inflammatory component.
Article
Multidisciplinary Sciences
Junke Liu, Hengmin Tang, Chanjuan Xu, Shengnan Zhou, Xunying Zhu, Yuanyuan Li, Laurent Prezeau, Tao Xu, Jean-Philippe Pin, Philippe Rondard, Wei Ji, Jianfeng Liu
Summary: This study reveals that the assembly of platelet-activating factor receptor (PAFR) into dimers and oligomers can significantly influence its signaling mode. Oligomerization enhances G protein coupling, while restraining beta-arrestin recruitment and internalization.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla
Summary: In patients with ovarian cancer, high expression of PAFR affects overall and recurrence-free survival, while rupatadine, an antagonist, effectively inhibits proliferation and migration of ovarian cancer cells.
Article
Chemistry, Medicinal
JiaYuan Xu, Wang Chen, ZiLi Feng, CongXue Duan, Bin Wang, ZhengDong Zhao
Summary: Ginkgolide B, a natural product, was modified to obtain 10 derivatives. These derivatives exhibited inhibitory activity against rabbit platelet aggregation induced by platelet activating factor, with 4 derivatives showing strong inhibitory activity.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Food Science & Technology
Mingming Li, Xin Zhang, Jiapeng Li, Linggao Liu, Qiujin Zhu, Chao Qu, Yunhan Zhang, Shouwei Wang
Summary: This study investigated the isolation, purification, and identification of potential cardioprotective bioactive peptides from dry-cured pork coppa. The results showed that M1F2 peptide had a higher inhibitory effect on cardiovascular inflammation compared to M2F2. Nano-liquid chromatography-tandem mass spectrometry identified a total of 30 peptides, among which LTDKPFL, VEAPPAKVP, KVPVPAPK, IPVPKK, and PIKRSP were found to be promising platelet-activating factor acetyl hydrolase inhibitory peptides. Overall, bioactive peptides produced during the processing of dry-cured pork coppa have positive effects on human health.
Article
Biochemistry & Molecular Biology
Carolyn J. English, Anna E. Lohning, Hannah L. Mayr, Mark Jones, Dianne P. Reidlinger
Summary: Traditionally, cardiovascular disease (CVD) risk has been assessed through blood lipids and the inflammatory marker C-reactive protein (hsCRP). However, recent research has shown that the pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) can also indicate vascular damage in the absence of traditional risk factors. This study investigated the relationship between PAF, Lp-PLA(2), hsCRP, and traditional risk factors for CVD among 100 adults. The results showed that PAF, Lp-PLA(2), and hsCRP were independently correlated with various CVD risk factors, suggesting their involvement in different atherogenic pathways.
Article
Chemistry, Medicinal
Noraziah Nordin, Juriyati Jalil, Mohd Faiz Abd Ghani, Adib Afandi Abdullah, Rozana Othman
Summary: Naturally derived flavonoids have been found to potentially act as promising PAF antagonists with some level of inhibitory activity. Further investigation is needed to develop new drug candidates for PAF-mediated diseases.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Linyue Dong, Yiming Li, Huali Wu
Summary: Intracellular platelet activating-factor acetylhydrolase type II (PAF-AH II) is a monomeric enzyme with broad substrate specificity and various functions such as protection against oxidative stress, transacetylase activity, and producing lipid mediators. It has been proven to be involved in several diseases and has drawn attention from researchers.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Article
Cell Biology
Yuchen Li, Yao Liu, Pei Wu, Yang Tian, Binbing Liu, Jinju Wang, Ji Bihl, Huaizhang Shi
Summary: Ferroptosis plays a key role in early brain injury (EBI) in SAH patients. The inhibitor Fer-1 shows neuroprotection by alleviating ferroptosis and potentially suppressing lipid peroxidation in EBI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Huiting Zhang, Qunwen Pan, Zi Xie, Yanyu Chen, Jinju Wang, Ji Bihl, Wangtao Zhong, Yanfang Chen, Bin Zhao, Xiaotang Ma
TRANSLATIONAL STROKE RESEARCH
(2020)
Article
Medicine, Research & Experimental
Liping Liu, Qinmao Ye, Langni Liu, Ji Chen Bihl, Yanfang Chen, Jing Liu, Qian Cheng
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Qunwen Pan, Xiaoli Kuang, Shuyun Cai, Xiang Wang, Donghui Du, Jinju Wang, Yan Wang, Yanyu Chen, Ji Bihl, Yanfang Chen, Bin Zhao, Xiaotang Ma
STEM CELL RESEARCH & THERAPY
(2020)
Article
Neurosciences
Jinju Wang, Shuzhen Chen, Wenfeng Zhang, Yanfang Chen, Ji C. Bihl
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Article
Cell Biology
Jinju Wang, Venkata Polaki, Shuzhen Chen, Ji C. Bihl
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Review
Neurosciences
Sri Meghana Yerrapragada, Ji Chen Bihl
Summary: Adipose tissue-released exosomes play a modulatory role in the brain by transporting bioactive molecules, particularly miRNAs, and may serve as potential therapeutic targets for neurological disorders.
NEUROMOLECULAR MEDICINE
(2022)
Article
Toxicology
Azeezat A. Awoyemi, Christina Borchers, Langni Liu, Yanfang Chen, Christine M. Rapp, Chad A. Brewer, Ramzi Elased, Jeffrey B. Travers
Summary: Ethanol has been found to modulate the generation and release of larger microvesicle particles, providing a novel mechanism for ethanol-mediated effects, which could be relevant in the significant toxicity associated with thermal burn injury.
TOXICOLOGY LETTERS
(2022)
Article
Cell & Tissue Engineering
Manasi Suchit Halurkar, Jinju Wang, Shuzhen Chen, Ji Chen Bihl
Summary: The study confirms that EPC-EXs can protect astrocytes from damage caused by HG and H/R, and miR-126 enriched EPC-EXs enhance their protective effects.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Langni Liu, Azeezat A. Awoyemi, Katherine E. Fahy, Pariksha Thapa, Christina Borchers, Benita Y. Wu, Cameron L. McGlone, Benjamin Schmeusser, Zafer Sattouf, Craig A. Rohan, Amy R. Williams, Elizabeth E. Cates, Christina Knisely, Lisa E. Kelly, Ji C. Bihl, David R. Cool, Ravi P. Sahu, Jinju Wang, Yanfang Chen, Christine M. Rapp, Michael G. Kemp, R. Michael Johnson, Jeffrey B. Travers
Summary: UVB radiation is a major cause of skin cancer, inducing immunosuppression and the release of MVPs containing bioactive substances like PAFR agonists. Activation of PAFR in keratinocytes by UVB exposure leads to the generation of UVB-MVPs, which can affect systemic immunity in both mice and humans.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
