Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

Redox Control of the Ubiquitin-Proteasome System: From Molecular Mechanisms to Functional Significance

(2011) Franziska Kriegenburg et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin

(2011) Hui Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characteristics of the turnover of uncoupling protein 3 by the ubiquitin proteasome system in isolated mitochondria

(2011) Shona A. Mookerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

(2011) Emily M. Lynes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?

(2011) Fang Hu et al.   CELLULAR SIGNALLING

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

(2011) Jeffrey L Brodsky et al.   CURRENT OPINION IN CELL BIOLOGY

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

(2011) Mariusz Karbowski et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of cellular protein quality control networks in a multicellular organism

(2011) Yael Bar-Lavan et al.   FEBS Journal

What distinguishes GroEL substrates from other Escherichia coli proteins?

(2011) Ariel Azia et al.   FEBS Journal

Ubiquitin-dependent mitochondrial protein degradation

(2011) Jin-Mi Heo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis

(2011) Albert Neutzner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease

(2011) Tom Bender et al.   MOLECULAR BIOLOGY OF THE CELL

Exposed hydrophobicity is a key determinant of nuclear quality control degradation

(2011) Eric K. Fredrickson et al.   MOLECULAR BIOLOGY OF THE CELL

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

Structural Basis of an ERAD Pathway Mediated by the ER-Resident Protein Disulfide Reductase ERdj5

(2011) Masatoshi Hagiwara et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins

(2011) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Cdc48: a power machine in protein degradation

(2011) Alexandra Stolz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

(2011) Robert Ernst et al.   PLOS BIOLOGY

Ubiquitin–Proteasome System and mitochondria — Reciprocity

(2010) Nurit Livnat-Levanon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum

(2010) Lori A Rutkevich et al.   CURRENT OPINION IN CELL BIOLOGY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Degradation of an intramitochondrial protein by the cytosolic proteasome

(2010) V. Azzu et al.   JOURNAL OF CELL SCIENCE

A PDI Family Network Acts Distinctly and Coordinately with ERp29 To Facilitate Polyomavirus Infection

(2010) C. P. Walczak et al.   JOURNAL OF VIROLOGY

A Nucleus-based Quality Control Mechanism for Cytosolic Proteins

(2010) Rupali Prasad et al.   MOLECULAR BIOLOGY OF THE CELL

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

(2010) Nadinath B. Nillegoda et al.   MOLECULAR BIOLOGY OF THE CELL

The Endoplasmic Reticulum–associated Degradation of the Epithelial Sodium Channel Requires a Unique Complement of Molecular Chaperones

(2010) Teresa M. Buck et al.   MOLECULAR BIOLOGY OF THE CELL

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control

(2010) Mario H. Bengtson et al.   NATURE

Cyclosporine A-Sensitive, Cyclophilin B-Dependent Endoplasmic Reticulum-Associated Degradation

(2010) Riccardo Bernasconi et al.   PLoS One

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Lectin chaperones help direct the maturation of glycoproteins in the endoplasmic reticulum

(2009) Bradley R. Pearse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation

(2009) Seong-Ok Lee et al.   EMBO JOURNAL

Protein Quality Control in Mitochondria

(2009) T. Tatsuta   JOURNAL OF BIOCHEMISTRY

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins

(2009) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin ligase E6-AP promotes degradation of α-synuclein

(2009) Shalaka A. Mulherkar et al.   JOURNAL OF NEUROCHEMISTRY

The Ubiquitin Ligase Hul5 Promotes Proteasomal Processivity

(2009) S. Aviram et al.   MOLECULAR AND CELLULAR BIOLOGY

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases

(2009) Wolfgang Voos   RESEARCH IN MICROBIOLOGY

Life and death of a BiP substrate

(2009) Joel H. Otero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

N-glycan structures: recognition and processing in the ER

(2009) Markus Aebi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

Ubiquitin Ligase Hul5 Is Required for Fragment-specific Substrate Degradation in Endoplasmic Reticulum-associated Degradation

(2008) Sonja Kohlmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

(2008) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C

(2008) Mei Dong et al.   MOLECULAR BIOLOGY OF THE CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

(2008) R. Ushioda et al.   SCIENCE