Extended and Structurally Supported Insights into Extracellular Hormone Binding, Signal Transduction and Organization of the Thyrotropin Receptor

The Thyrotropin Receptor Hinge Region as a Surrogate Ligand: Identification of Loci Contributing to the Coupling of Thyrotropin Binding and Receptor Activation

(2012) Chun-Rong Chen et al.   ENDOCRINOLOGY

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

(2012) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers

(2012) Maxime Zoenen et al.   Nature Communications

Identification of Novel TSH Interaction Sites by Systematic Binding Analysis of the TSHR Hinge Region

(2011) Sandra Mueller et al.   ENDOCRINOLOGY

The Hinge Region of the TSH Receptor Stabilizes Ligand Binding and Determines Different Signaling Profiles of Human and Bovine TSH

(2011) Holger Jaeschke et al.   ENDOCRINOLOGY

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

(2011) Michael D. Allen et al.   FASEB JOURNAL

Defining Structural and Functional Dimensions of the Extracellular Thyrotropin Receptor Region

(2011) Gunnar Kleinau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Molecular Details of the Interplay between Transmembrane Helices of the Thyrotropin Receptor to General Aspects of Signal Transduction in Family A G-protein-coupled Receptors (GPCRs)

(2011) Gunnar Kleinau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Research Resource: Update and Extension of a Glycoprotein Hormone Receptors Web Application

(2011) Annika Kreuchwig et al.   MOLECULAR ENDOCRINOLOGY

Neuroendocrine cells in Drosophila melanogaster producing GPA2/GPB5, a hormone with homology to LH, FSH and TSH

(2010) Azza Sellami et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors

(2010) Gunnar Kleinau et al.   HUMAN MUTATION

Functional Differences of Invariant and Highly Conserved Residues in the Extracellular Domain of the Glycoprotein Hormone Receptors

(2010) Krassimira Angelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain

(2010) Chun-Rong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function

(2010) Sepehr Hamidi et al.   MOLECULAR ENDOCRINOLOGY

Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors

(2009) Rongbin Guan et al.   CELLULAR SIGNALLING

Thyrotropin and Homologous Glycoprotein Hormone Receptors: Structural and Functional Aspects of Extracellular Signaling Mechanisms

(2009) Gunnar Kleinau et al.   ENDOCRINE REVIEWS

The Superagonistic Activity of Bovine Thyroid-stimulating Hormone (TSH) and the Human TR1401 TSH Analog Is Determined by Specific Amino Acids in the Hinge Region of the Human TSH Receptor

(2009) Sandra Mueller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative structure analyses of cystine knot-containing molecules with eight aminoacyl ring including glycoprotein hormones (GPH) alpha and beta subunits and GPH-related A2 (GPA2) and B5 (GPB5) molecules

(2009) Eva Alvarez et al.   Reproductive Biology and Endocrinology

The specificity of binding of glycoprotein hormones to their receptors

(2008) G. Caltabiano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extended Hormone Binding Site of the Human Thyroid Stimulating Hormone Receptor

(2008) Sandra Mueller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asp330and Tyr331in the C-terminal Cysteine-rich Region of the Luteinizing Hormone Receptor Are Key Residues in Hormone-induced Receptor Activation

(2008) Martijn Bruysters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cleavage of thyroid-stimulating hormone receptor is dependent on cell-cell contacts and regulates the hormonal stimulation of phospholipase c

(2008) Mai-Thu Vu Hai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Thyrotropin Receptor Hinge Region Is Not Simply a Scaffold for the Leucine-Rich Domain but Contributes to Ligand Binding and Signal Transduction

(2008) Yumiko Mizutori et al.   MOLECULAR ENDOCRINOLOGY

Comparative structural analysis of the binding domain of follicle stimulating hormone receptor

(2008) Qing R. Fan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha2 (GPA2) and beta5 (GPB5)

(2008) Yoshiki Okajima et al.   REGULATORY PEPTIDES