From Molecular Details of the Interplay between Transmembrane Helices of the Thyrotropin Receptor to General Aspects of Signal Transduction in Family A G-protein-coupled Receptors (GPCRs)

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor

(2010) Gunnar Kleinau et al.   FASEB JOURNAL

Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients

(2010) Heike Biebermann   Frontiers in Bioscience-Landmark

An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors

(2010) Gunnar Kleinau et al.   HUMAN MUTATION

Conserved Water-mediated Hydrogen Bond Network between TM-I, -II, -VI, and -VII in 7TM Receptor Activation

(2010) Rie Nygaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

(2010) K. Sansuk et al.   MOLECULAR PHARMACOLOGY

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes

(2010) Shixin Ye et al.   NATURE

Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor

(2010) Gunnar Kleinau et al.   PLoS One

Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors

(2009) Rongbin Guan et al.   CELLULAR SIGNALLING

Bioluminescence Resonance Energy Transfer Studies Reveal Constitutive Dimerization of the Human Lutropin Receptor and a Lack of Correlation between Receptor Activation and the Propensity for Dimerization

(2009) Rongbin Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Comparative Analysis of GPCR Crystal Structures

(2009) David T. Lodowski et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models

(2009) Catherine L. Worth et al.   PLoS One

Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface

(2009) P. Scheerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

(2009) S. Neumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-protein-coupled receptor structures were not built in a day

(2009) Tracy M. Blois et al.   PROTEIN SCIENCE

Discovery of New GPCR Biology: One Receptor Structure at a Time

(2009) Michael A. Hanson et al.   STRUCTURE

Identification and Functional Characterization of Two Novel Activating Thyrotropin Receptor Mutants in Toxic Thyroid Follicular Adenomas

(2009) Isabel Castro et al.   THYROID

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multiple Switches in G Protein-Coupled Receptor Activation

(2009) Shivani Ahuja et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation

(2008) Chi Shing Sum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic Region

(2008) Tatsuro Shimamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atomistic Insights into Rhodopsin Activation from a Dynamic Model

(2008) Irina G. Tikhonova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescence Resonance Energy Transfer Analysis of  2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes

(2008) A. Zurn et al.   MOLECULAR PHARMACOLOGY

Signal transduction: The rhodopsin story continued

(2008) Gebhard F. X. Schertler   NATURE

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of squid rhodopsin

(2008) Midori Murakami et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

A Heterozygous Mutation in the Third Transmembrane Domain Causes a Dominant-Negative Effect on Signalling Capability of the MC4R

(2008) Patrick Tarnow et al.   Obesity Facts

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Conformational changes involved in G-protein-coupled-receptor activation

(2008) Jürgen Wess et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

New G-protein-coupled receptor crystal structures: insights and limitations

(2008) B KOBILKA et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2

(2007) Francesca Deflorian et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS