Article
Biochemistry & Molecular Biology
Jorge Gonzalez-Zamora, Maria Hernandez, Sergio Recalde, Jaione Bezunartea, Ana Montoliu, Valentina Bilbao-Malave, Josune Orbe, Jose A. Rodriguez, Sara Llorente-Gonzalez, Patricia Fernandez-Robredo, Alfredo Garcia-Layana
Summary: Age-related macular degeneration is the leading cause of severe visual loss in older adults in developed countries. The role of oxidative stress and matrix metalloproteinases, particularly MMP10, in the pathophysiology of AMD is of great interest. This study aimed to clarify the involvement of MMP10 in choroidal neovascularization and found that it plays a significant role in its development, making it a potential therapeutic target.
Article
Multidisciplinary Sciences
Yue Li, Siyuan Fan, Lingyao Kong, Zhenxuan Hao, Yanjun Zhou, Jiahong Shangguan, Lu Gao, Mingdan Wang, Yue Kang, Xiangrao Li, Kun Huang, Chao Zhang, Zhibo Liu
Summary: This study found that CD9 exacerbates pathological cardiac hypertrophy by regulating the GP130/STAT3 signaling pathway. The results provide important insights into the pathogenesis of heart diseases.
Article
Cell Biology
Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Cho
Summary: Research found that microglia activation is associated with neuronal lesions in diabetes, with STAT3 activation playing a crucial role in neuronal apoptosis in the diabetic hippocampus.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Ophthalmology
Ioanna Tsioti, Beatrice L. Steiner, Pascal Escher, Martin S. S. Zinkernagel, Peter M. M. Benz, Despina Kokona
Summary: This study investigates the effect of systemic lipopolysaccharide (LPS) stimulus on laser-induced choroidal neovascularization (CNV) in mice. The results show that LPS leads to increased fluorescein leakage after 3 days of CNV, along with an influx of monocyte-derived macrophages and an increase in pro-inflammatory microglia/macrophages in the retina. Additionally, LPS enhances Vegf alpha mRNA expression in certain cells. These findings suggest that systemic LPS exposure has transient detrimental effects in the course of CNV through activation of microglia/macrophages and supports their important role in CNV.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Medicine, General & Internal
Bide Duan, Yuan Li, Hui Geng, Airong Ma, Xiuzhi Yang
Summary: Naringenin significantly reduced blood pressure, total urine protein level, plasma levels of VCE, alpha-ADR, and angiotensin in PIH mice. It also decreased pro-inflammatory cytokines and oxidative stress markers while increasing anti-inflammatory cytokine levels. Naringenin inhibited JAK2/STAT3 signalling by promoting SHP-1 expression, contributing to the improvement of hypertension in pregnancy.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Alberto Ruiz Priego, Emilio Gonzalez Parra, Sebastian Mas, Jose Luis Morgado-Pascual, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: This study demonstrates that chronic exposure to BPA can lead to inflammatory infiltration, tubular injury, and fibrosis in the kidneys of healthy mice, and exacerbation of renal lesions in SNX mice. BPA also modulates the autophagy process and redox protective mechanisms in the kidneys, suggesting potential harmful effects of BPA in the kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Eunhye Yu, Yunjeong Song, Sun Mi Gu, Yang Hee Jo, Sang Won Yeon, Kyu Jin Han, Mi Kyeong Lee, Jung Kee Min, Jaesuk Yun
Summary: Age-related macular degeneration (AMD) is a common cause of vision loss in the elderly population. Anti-vascular endothelial growth factor (VEGF) antibody therapy is effective in treating neovascularization in AMD, but the prevention of fibrosis remains a challenge. This study demonstrates the anti-fibrotic and anti-neovascularization effects of alpinumisoflavone (AIF) in vitro and in vivo, suggesting its potential as a therapeutic option for the treatment of neovascular AMD.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Yuanjie Yu, Tian Tian, Shiyun Tan, Pengbo Wu, Yitian Guo, Ming Li, Mengjun Huang
Summary: The study suggests that miR-665-3p plays a significant role in exacerbating oxidative stress and inflammation in NAFLD. Inhibiting miR-665-3p could be a potential therapeutic strategy for preventing NAFLD progression.
Article
Medicine, Research & Experimental
Weili Jin, Jixing Zhao, Eryan Yang, Yunfei Wang, Qixue Wang, Ye Wu, Fei Tong, Yanli Tan, Junhu Zhou, Chunsheng Kang
Summary: This study found that PTRF is significantly increased in neuronal cells after cerebral ischemia-reperfusion (I/R) injury, and it aggravates the damage by regulating the activity and stability of PLA2G4A. This finding provides a new therapeutic target for ischemic stroke.
Article
Pharmacology & Pharmacy
Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihara
Summary: This study revealed the significant role of Nrf2 in acrylamide-induced neurotoxicity, with Nrf2-knockout mice showing more severe neurodegeneration and inflammation when exposed to acrylamide.
Article
Dermatology
Lei Zhou, Han Zhao, He Zhao, Xin Meng, Zhixiang Zhao, Hongfu Xie, Ji Li, Yan Tang, Yiya Zhang
Summary: This study revealed the important role of macrophages in rosacea and identified GBP5 as a key regulator of rosacea by inducing M1 macrophage polarization via NF-kappa B signaling pathways.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Microbiology
Amy Parrish, Marie Boudaud, Erica T. Grant, Stephanie Willieme, Mareike Neumann, Mathis Wolter, Sophie Z. Craig, Alessandro De Sciscio, Antonio Cosma, Oliver Hunewald, Markus Ollert, Mahesh S. Desai
Summary: A study found that deprived of dietary fiber leads to changes in the gut microbiota, specifically an increase in the mucin-degrading bacterium Akkermansia muciniphila. This change is associated with intestinal barrier dysfunction, increased expression of type 1 and 2 cytokines, and IgE-coated commensals in the colon, which worsen allergic reactions to food allergens. The study provides important insights into how gut microbes can regulate immune pathways of food allergy in a diet-dependent manner.
NATURE MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shu-Yuan Hsu, Chih-Hung Chen, Sujira Mukda, Steve Leu
Summary: Cerebral stroke is one of the leading causes of death worldwide. Pnn deficiency increases oxidative stress in neurons and exacerbates cerebral ischemia/reperfusion injury.
Article
Biochemistry & Molecular Biology
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Elise Hong, Ravikiran Komirisetty, Eduardo Araujo, Steven Nusinowitz, Srinivasa Reddy, Ram Kannan
Summary: Oxidative stress plays a crucial role in the development of AMD, and PON2 has been found to have a beneficial role in preserving retinal function and protecting against mitochondrial dysfunction.
Article
Cell Biology
Lingyan Chen, Dejian Chen, Jiwei Li, Lipeng He, Ting Chen, Dandan Song, Shuang Shan, Jiaxin Wang, Xiaoang Lu, Bin Lu
Summary: Ciclopirox (CPX), an antifungal drug, has shown promising potential as a treatment for gastric cancer (GC). It inhibits GC growth through suppressing proliferation and stimulating autophagic cell death. Mechanistically, CPX regulates the phosphorylation of STAT3 at Tyr705 and Ser727 residues to regulate cell growth and autophagic cell death.
CELL DEATH & DISEASE
(2022)
Article
Geography, Physical
Chuan Zhang, Gui Gao, Linlin Zhang, C. Chen, S. Gao, Libo Yao, Qilin Bai, Shiquan Gou
Summary: In this study, an adaptive ship detector using full-polarization SAR images was constructed and verified through experiments. The results showed that the proposed detector has a higher signal-clutter ratio and lower false alarm rate, indicating better detection accuracy compared to other methods.
ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING
(2022)
Article
Chemistry, Physical
Jialu Li, Libo Yao, Dezhen Wu, Jaelynne King, Steven S. C. Chuang, Bin Liu, Zhenmeng Peng
Summary: In this study, electrochemical methane oxidation reaction on iron-nickel hydroxide nanosheets was investigated. The Fe-Ni-OH catalysts showed good CH4OR activity in a specific potential range, with ethanol being the main product. The composition of the catalyst has a significant effect on the activity. Density functional theory simulations and in situ infrared characterizations confirmed the active site and reaction pathways. This study provides theoretical guidance for understanding methane oxidation reaction mechanisms and discovering effective catalyst materials.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Engineering, Environmental
Libo Yao, Yanbo Pan, Dezhen Wu, Abdulaziz Bentalib, Jialu Li, Bin Liu, Zhenmeng Peng
Summary: A new mechanism for direct CO reduction to formaldehyde (CORTF) is reported, which utilizes hydrogen underpotential deposition to balance the species coverage on the catalyst surface. By tuning the composition of Pt alloy catalyst and the potential of hydrogen underpotential deposition, the formaldehyde production rate is significantly increased.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li
Summary: This study found that splenic monocyte-derived macrophages migrate to the liver and shift to macrophages, exacerbating liver fibrosis. These findings reveal the important role of the spleen-liver axis in hepatic pathogenesis.
Review
Geochemistry & Geophysics
Linlin Zhang, Gui Gao, Chao Chen, Sheng Gao, Libo Yao
IEEE GEOSCIENCE AND REMOTE SENSING MAGAZINE
(2022)
Article
Chemistry, Physical
Jialu Li, Jinyao Tang, Dezhen Wu, Libo Yao, Zhenmeng Peng
Summary: This study presents a combined method of ethylamine dehydrogenation (EDH) and ethylamine electrolysis, which allows for fast and efficient release of hydrogen at ambient conditions. The results show that high hydrogen production rate and acetonitrile production can be achieved under low voltage, demonstrating the great potential of this new electrochemical approach for hydrogen storage applications.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Geriatrics & Gerontology
Caini Song, Libo Yao, Huisu Chen, Ying Song, Lihua Liu
Summary: This study conducted a meta-analysis to investigate the prevalence of depression and the factors influencing depression among home-bound empty nesters in China. The results showed that the overall prevalence of depression among empty nesters was 43%, and several factors such as gender, income, marital status, chronic illness, relationship with children, and social support were found to be significantly associated with depression among urban empty nesters. Based on the factors influencing depression, early intervention by government departments can help improve the mental health of empty nesters.
Article
Education & Educational Research
Caini Song, Libo Yao, Huisu Chen, Lihua Liu
Summary: This study analyzed the research hotspots and trends of nursing scenario simulation teaching at home and abroad, aiming to provide reference for future nursing talent education. The research focus in China is on the application and application effect of nursing scenario simulation teaching, while the research hotspots abroad are the quality evaluation, reliability, and influence of nursing scenario simulation teaching. In conclusion, the research and development of nursing scenario simulation teaching are gradually becoming more systematic.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Libo Yao, Claire Yin, Kevin E. Rivera-Cruz, Charles C. L. McCrory, Nirala Singh
Summary: The electrochemical CO2 reduction reaction (CO2RR) in gas-fed flow electrolyzers using gas diffusion electrodes (GDEs) has the potential for carbon recycling. Developing effective catalyst systems on GDEs is crucial for high CO2RR activity. This study bridges the knowledge gap between liquid reaction platforms and GDE architectures by demonstrating the case of a cobalt phthalocyanine (CoPc)-poly-4-vinylpyridine (P4VP) catalyst-polymer composite (CPC). The study highlights the importance of considering the hydrophobicity of CPCs in gas-fed CO2RR and incorporating an engineering perspective in CPC design and evaluation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Computer Science, Theory & Methods
Qiangqiang Jiang, Xu Xin, Libo Yao, Bo Chen
Summary: This paper proposes a multi-objective energy-efficient task scheduling technique (METSM) for edge heterogeneous multiprocessor systems. A mathematical model is established for the task scheduling problem, and a problem-specific algorithm (IMO) is designed for optimizing task scheduling and resource allocation. Experimental results show that the proposed algorithm can achieve optimal Pareto fronts and significantly save time and power consumption.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2024)
Review
Chemistry, Physical
Libo Yao, Kevin E. Rivera-Cruz, Nirala Singh, Charles C. L. McCrory
Summary: This article discusses the application of immobilized molecular catalysts (IMCs) in flow electrolyzers and the impact of the interactions between IMCs and different microenvironments on the performance of the electrochemical CO2 reduction reaction (CO2RR). Through electrochemical and spectroelectrochemical measurements as well as post-mortem catalyst characterization, a better understanding and optimization of the CO2RR performance of IMCs can be achieved.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Computer Science, Information Systems
Fan Zhao, Wenda Zhao, Huimin Lu, Yong Liu, Libo Yao, Yu Liu
Summary: A new depth-distilled multi-focus image fusion framework (D2MFIF) is proposed in this paper, which gradually improves the performance of multi-focus image fusion by adaptively transferring depth knowledge and integrating multi-level decision maps.
IEEE TRANSACTIONS ON MULTIMEDIA
(2023)
Article
Computer Science, Artificial Intelligence
Jiawen Zhu, Wenda Zhao, Libo Yao, You He, Maodi Hu, Xiaoxing Zhang, Shuo Wang, Tao Li, Huchuan Lu
Summary: In this paper, we propose CDENet, an end-to-end trainable network that can handle both crowd and confusion regions with similar appearance. CDENet consists of two modules for mining and erasing confusion regions. Experimental results on four crowd counting benchmarks demonstrate that CDENet achieves superior performance compared to state-of-the-art methods.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Geochemistry & Geophysics
Gui Gao, Ping Zhou, Libo Yao, Jia Liu, Chuan Zhang, Dingfeng Duan
Summary: Fine-grained ship classification in optical remote sensing images is a challenging task in the ocean observation field due to the expensive cost of acquiring ship images, complex background interference, and the similarity and diversity among different ships. In this study, a lightweight adaptive task attention-bi-prototype-Brownian distance covariance (LATA-BP-BDC) method is proposed to address these challenges and achieve superior performance in few-shot ship classification.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2023)
Review
Chemistry, Physical
Libo Yao, Kevin E. Rivera-Cruz, Nirala Singh, Charles C. L. Mccrory
Summary: This perspective highlights recent studies on the interactions between immobilized molecular catalysts (IMCs) and microenvironment in gas diffusion electrode (GDE) configurations for the electrochemical CO2 reduction reaction (CO2RR). The transition from batch cells to flow electrolyzers poses challenges due to the drastic differences in microenvironment and a lack of understanding of its effects on CO2RR performance. Strategies such as electrochemical measurements, in situ spectroelectrochemical measurements, and post-mortem catalyst characterization are suggested for better understanding of microenvironment effects.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)