Article
Gastroenterology & Hepatology
Nobukatsu Horita, Theresa M. Keeley, Elise S. Hibdon, Elizabeth Delgado, Daniel Lafkas, Christian W. Siebel, Linda C. Samuelson
Summary: This study identified specific Notch ligands and Niche cells that regulate stem cell proliferation in the distal mouse stomach. DLL1 was found to be the key Notch ligand that regulates epithelial cell proliferation in the gastric antrum.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Kalafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Muller, Lidia Borkiewicz
Summary: Notch1 signaling plays a diverse role in tissue development and homeostasis. The relationship between NOTCH1 expression and the development of health disorders, especially cancers, is intensively studied. Control of Notch1 signaling involves not only transcriptional regulation but also various post-translational events, including ligand-dependent mechanical activation and interaction with other signaling molecules, such as long non-coding RNAs (lncRNAs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
M. Fethullah Simsek, Angad Singh Chandel, Didar Saparov, Oriana Q. H. Zinani, Nicholas Clason, Ertugrul M. Ozbudak
Summary: This study developed precise reporters to measure the clock and ppErk gradient in zebrafish. It found that the Her1-Her7 oscillator drives segmental commitment by periodically lowering ppErk, therefore projecting its oscillation onto the ppErk gradient. Pulsatile inhibition of the ppErk gradient can fully substitute for the role of the clock, and kinematic clock waves are dispensable for sequential segmentation.
Review
Cell & Tissue Engineering
Xi-Min Hu, Zhi-Xin Li, Dan-Yi Zhang, Yi-Chao Yang, Shen-ao Fu, Zai-Qiu Zhang, Rong-Hua Yang, Kun Xiong
Summary: Hair follicle stem cells (HFSCs) are valuable resources for studying adult stem cells and hair loss therapy, with potential therapeutic targets for skin and hair disorders. Multiple signaling pathways are involved in regulating the fate of HFSCs, providing a better understanding of pathophysiological changes in the HFSC niche.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Hematology
Helal Mohammed Mohammed Ahmed, Subbaiah Chary Nimmagadda, Yahya S. Al-Matary, Maren Fiori, Tobias May, Daria Frank, Pradeep Kumar Patnana, Christian Recher, Christoph Schliemann, Jan-Henrik Mikesch, Thorsten Koenig, Frank Rosenbauer, Wolfgang Hartmann, Jan Tuckermann, Ulrich Duhrsen, Wei Lanying, Martin Dugas, Bertram Opalka, Georg Lenz, Cyrus Khandanpour
Summary: This study showed functional differences between AML MSCs and HD MSCs, with Notch signaling in AML MSCs enhancing AML cell proliferation, while dexamethasone or Notch inhibitors could disrupt the interaction between AML cells and AML MSCs, improving treatment outcomes in AML patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Mathematics
Ahmed Salem, Lamya Almaghamsi
Summary: The sequential fractional differential equations at resonance, subject to three-point boundary conditions, are studied. These equations involve fractional derivative operators based on the Caputo derivative of order between 1 and 2. The goal of this study is to investigate the existence of solutions for the boundary value problem using the coincidence degree theory by Mawhin, which relies on Fredholm operators with zero index and two continuous projectors. An example is given to illustrate the theoretical results.
Article
Biochemistry & Molecular Biology
Torcato Martins, Yao Meng, Boguslawa Korona, Richard Suckling, Steven Johnson, Penny A. Handford, Susan M. Lea, Sarah J. Bray
Summary: Accurate Notch signalling is crucial for development and homeostasis, with recent studies showing the importance of the conserved N-terminal C2 domain in Notch ligands. Mutations in the beta 1-2 loop of the Delta C2 domain affect phospholipid binding and compromise ligand function in vivo. These findings highlight the essential role of C2 domain phospholipid binding in fine-tuning the balance of trans and cis ligand-receptor interactions for robust signalling.
Article
Biochemistry & Molecular Biology
Ranjith Viswanathan, Jonas Hartmann, Cristina Pallares Cartes, Stefano De Renzis
Summary: This study uses optogenetics to control Notch signaling activation with high precision during Drosophila embryogenesis and observes dynamic adaptation of target gene transcription over time. The results reveal a novel mechanism of dynamic nuclear adaptation in controlling Notch signaling output during tissue differentiation, providing insights into the translation of signaling inputs into gene expression outputs.
Article
Multidisciplinary Sciences
Oceane Tourniere, James M. Gahan, Henriette Busengdal, Natascha Bartsch, Fabian Rentzsch
Summary: Using the sea anemone Nematostella vectensis as a model system, researchers found that neurons and secretory cells derive from a common pool of progenitor cells, with NvInsm1 playing a crucial role in this process, revealing a close evolutionary relationship between neurons and secretory cells.
Article
Chemistry, Multidisciplinary
Pengcheng Jia, Liang Qin, Di Zhao, Yang Tang, Bo Song, Junhan Guo, Xiaomeng Li, Ling Li, Qiuhong Cui, Yufeng Hu, Zhidong Lou, Feng Teng, Yanbing Hou
Summary: The performance of perovskite solar cells is greatly influenced by the crystallization of the perovskite active layer, with neatly arranged crystal grains promoting less residual charge and improved device performance. The testing of residual charge at grain boundaries provides insight into carrier trap and detrap characteristics in photovoltaic devices.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Cell Biology
Xi Xu, Wenwen Zhang, Li Xuan, Yanhui Yu, Wen Zheng, Fang Tao, Jacqelyn Nemechek, Chong He, Weiwei Ma, Xue Han, Siyu Xie, Minyi Zhao, Jian Wang, Yuhua Qu, Qifa Liu, John M. Perry, Linjia Jiang, Meng Zhao
Summary: “T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy. In this study, a rare inhibitory receptor called programmed cell death 1 (PD-1) was identified as a marker for leukemia stem cells (LSCs) in T-ALL. Blocking PD-1 significantly eradicated LSCs and suppressed disease progression, and combination therapy with PD-1 blockade and chemotherapy extended survival. Mechanistically, PD-1+ LSCs had high NOTCH1-MYC activity and were protected against apoptosis. These findings provide a therapeutic approach for eliminating LSCs in T-ALL.”
NATURE CELL BIOLOGY
(2023)
Article
Oncology
Luigi Corsaro, Vincenzo Sandro Gambino
Summary: Oestrogen receptor expression in breast cancer cells is a marker for high cellular differentiation and can be used to identify two distinct breast cancer groups (ER-positive and ER-negative) with differences in biological characteristics, clinical behavior, and therapeutic options. This study used epigenetic wide association study datasets to compare these two breast cancer groups using an epimutation score. Functional and pathway enrichment analyses revealed common genetic pathways associated with higher and significant epimutation scores in ER-positive breast cancer, including the SUMOylation, Notch, IFN-γ signaling, and deubiquitination protease pathways. On the other hand, ER-positive breast cancer was also associated with a higher and significant level of epimutation due to hypomethylation in genes belonging to the ESR-mediated pathway, consistent with an active estrogen-mediated signaling pathway in this group.
Article
Multidisciplinary Sciences
Quentin I. B. Lemaitre, Natascha Bartsch, Ian U. Kouzel, Henriette Busengdal, Gemma Sian Richards, Patrick R. H. Steinmetz, Fabian Rentzsch
Summary: Endodermal neurogenesis is a rare phenomenon in animals. Researchers have identified a group of endoderm-specific neural progenitor cells in the cnidarian Nematostella vectensis, characterized by the expression of the transcription factor prdm14d. This study sheds light on the molecular regulation of non-ectodermal neurogenesis using Nematostella vectensis as a model, providing new insights into this poorly understood process.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Craig T. Jacobs, Peng Huang
Summary: The development of the vertebrate central nervous system is tightly regulated by highly conserved cell signalling pathways, with Notch and Hedgehog pathways playing key roles. These pathways interact in a complex manner throughout CNS development, with Notch signaling often regulating Hedgehog response and vice versa. The intricate crosstalk between Notch and Hedgehog pathways highlights the interconnectivity and context-dependent modes of interaction between them, within a wider, multi-pathway signalling network.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Developmental Biology
Corey G. K. Flynn, Paul R. Ginkel, Katharine A. Hubert, Qingyuan Guo, Steven M. Hrycaj, Aubrey E. McDermott, Angelo Madruga, Anna P. Miller, Deneen M. Wellik
Summary: Interstitial stromal cells are crucial for muscle development, regeneration, and repair. Hoxa11 and Hoxd11 are expressed in these cells and essential for embryonic patterning of muscles. Hoxa11eGFP expression continues in a subset of muscle interstitial cells through adult stages.