Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics

Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction

(2015)   Oncotarget

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

(2014) Grzegorz Popowicz et al.   CELL CYCLE

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations

(2012) Jianzhong Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interrogation of MDM2 Phosphorylation in p53 Activation Using Native Chemical Ligation: The Functional Role of Ser17 Phosphorylation in MDM2 Reexamined

(2012) Changyou Zhan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How phosphorylation controls p53

(2011) Nicola J. Maclaine et al.   CELL CYCLE

Chemical states of the N-terminal “lid” of MDM2 regulate p53 binding: Simulations reveal complexities of modulation

(2011) Shubhra Ghosh Dastidar et al.   CELL CYCLE

Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists

(2011) Yijun Huang et al.   ChemMedChem

Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists

(2011) Hong Shen et al.   CURRENT PHARMACEUTICAL DESIGN

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

Molecular modeling and molecular dynamics simulation studies on pyrrolopyrimidine-based α-helix mimetic as dual inhibitors of MDM2 and MDMX

(2011) Shao-Yong Lu et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Insight into mechanism of small molecule inhibitors of the MDM2–p53 interaction: Molecular dynamics simulation and free energy analysis

(2011) Jianzhong Chen et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Structure of the Stapled p53 Peptide Bound to Mdm2

(2011) Sohee Baek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms

(2011) Christopher J. Brown et al.   PLoS One

Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases

(2011) Anshuman Dixit et al.   PLoS Computational Biology

Mdm2 links genotoxic stress and metabolism to p53

(2011) Zhongfeng Wang et al.   Protein & Cell

The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides

(2010) Christopher John Brown et al.   CELL CYCLE

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

(2010) Anna Czarna et al.   CELL CYCLE

Differential binding of p53 and nutlin to MDM2 and MDMX: Computational studies

(2010) Thomas Leonard Joseph et al.   CELL CYCLE

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

(2010) Grzegorz M. Popowicz et al.   CELL CYCLE

Molecular Modeling Approaches in the Discovery of New Drugs for Anti-Cancer Therapy: The Investigation of p53-MDM2 Interaction and its Inhibition by Small Molecules

(2010) A. Lauria et al.   CURRENT MEDICINAL CHEMISTRY

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

A computational analysis of the binding model of MDM2 with inhibitors

(2010) Guodong Hu et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The Effects of Phosphomimetic Lid Mutation on the Thermostability of the N-terminal Domain of MDM2

(2010) Erin G. Worrall et al.   JOURNAL OF MOLECULAR BIOLOGY

Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

(2010) Chong Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

(2010) Peter Csermely et al.   TRENDS IN BIOCHEMICAL SCIENCES

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Apamin as a Template for Structure-Based Rational Design of Potent Peptide Activators of p53

(2009) Chong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

(2009) Shubhra Dastidar et al.   BMC BIOINFORMATICS

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Thermodynamic and Computational Studies on the Binding of p53-Derived Peptides and Peptidomimetic Inhibitors to HDM2

(2009) Anja Grässlin et al.   CHEMBIOCHEM

Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

(2009) Joerg Kallen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

(2009) Jason Phan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Study of MDM2 Binding to p53-Analogues: Affinity, Helicity, and Applicability to Drug Design

(2009) Ori Kalid et al.   Journal of Chemical Information and Modeling

Ensemble-based virtual screening reveals dual-inhibitors for the p53–MDM2/MDMX interactions

(2009) Khaled Barakat et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

(2009) M. Pazgier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of MDM2 by multisite phosphorylation—Opportunities for molecular-based intervention to target tumours?

(2009) David W. Meek et al.   SEMINARS IN CANCER BIOLOGY

Quantum Mechanical Studies of Residue-Specific Hydrophobic Interactions in p53−MDM2 Binding

(2008) Yun Ding et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Multiple Peptide Conformations Give Rise to Similar Binding Affinities: Molecular Simulations of p53-MDM2

(2008) Shubhra Ghosh Dastidar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Lid Dynamics of MDM2 Reveals Differential Ligand Binding Modes of the p53-Binding Cleft

(2008) Scott A. Showalter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The genetics of the p53 pathway, apoptosis and cancer therapy

(2008) Alexei Vazquez et al.   NATURE REVIEWS DRUG DISCOVERY

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

(2008) O. F. Lange et al.   SCIENCE