Article
Immunology
Lifei Hou, Koichi Yuki
Summary: This study reveals the importance of CD11c in maintaining T cell survival by showing that CD11c deficiency leads to defects in T cell development in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Carolina Francelin, Luciana Peixoto Veneziani, Alessandro dos Santos Farias, Daniella Areas Mendes-da-Cruz, Wilson Savino
Summary: The thymus serves as a model for investigating the neuroimmune network, with neurotransmitters and receptors playing key roles in the regulation of thymocyte development and function. Numerous neurotransmitters of non-neuronal origin are produced within the thymus and are likely important players in T-cell development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao
Summary: Cell metabolism plays a critical role in regulating T cell development, directing different metabolic pathways and signaling networks to match the specific functional requirements of different stages. Understanding this interplay may offer new therapeutic approaches to selectively regulate T cell subset functions and modulate autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Sarah-Jolan Bremer, Laura Glau, Christina Gehbauer, Annika Boxnick, Daniel Biermann, Joerg Siegmar Sachweh, Eva Tolosa, Anna Gieras
Summary: This panel is designed to identify and characterize the different developmental stages of human thymocytes, covering 14 major stages and various cell types and maturity levels. Specific antibodies relevant for certain developmental steps are added to highlight important checkpoints during T cell development.
Article
Immunology
Lawrence P. Andrews, Kate M. Vignali, Andrea L. Szymczak-Workman, Amanda R. Burton, Erin A. Brunazzi, Shin Foong Ngiow, Akihito Harusato, Arlene H. Sharpe, E. John Wherry, Ichiro Taniuchi, Creg J. Workman, Dario A. A. Vignali
Summary: This study developed a new mouse line for precise gene manipulation in CD4(+) T cells and CD4(+) Tconv cells, which was validated through comparisons with existing mouse lines targeting CD8(+) T cells. These engineered mouse strains provide a valuable resource for temporal control of gene expression in specific T cell populations.
Article
Immunology
Wenting Li, Yang Yang, Shenglin Liu, Dongsheng Zhang, Xuanyao Ren, Mindan Tang, Wei Zhang, Xiaofan Chen, Cong Huang, Bo Yu
Summary: Deletion of Paxbp1 gene results in decreased number of CD4(+)CD8(+) intermediate stage cells and thymic atrophy in T cell development. It also affects the number of CD4 and CD8 single positive T cells and peripheral T cells. The deficiency of Paxbp1 gene increases the susceptibility of CD4(+)CD8(+) thymocytes to apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Talang Wang, Ruoyu Zhao, Junhong Zhi, Ziling Liu, Aiwei Wu, Zimei Yang, Weixu Wang, Ting Ni, Lili Jing, Ming Yu
Summary: Tox4 protein is a regulator of PP1 phosphatases with unknown function in development. In mice, conditional knockout of Tox4 reduces thymic cellularity, partially blocks T cell development, and decreases the ratio of CD8 to CD4 cells. Tox4 loss also impairs proliferation of the fast-proliferating DP blast population within DP cells through downregulation of genes critical for proliferation, and genes with high and low expression level are more dependent on Tox4. Mechanistically, Tox4 may facilitate transcriptional reinitiation and restrict elongation in a dephosphorylation-dependent manner, and it is an evolutionarily conserved regulator of transcriptional elongation and reinitiation. Tox4 controls T cell development in mice by regulating transcription of cell cycle regulation genes via PP1 phosphatases, independent of chromatin accessibility modulation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Microbiology
Sharada Swaminathan, Tatiana Scorza, Alexis Yero, Omar Farnos, Stephanie C. Burke C. Schinkel, Jonathan B. Angel, Mohammad-Ali Jenabian
Summary: During HIV infection, the frequencies of regulatory T cells (Tregs) increase in the peripheral blood and lymphoid tissues, contributing to immune dysfunction and disease progression. However, thymic Tregs (tTregs) show reduced susceptibility to HIV infection compared to other thymocytes. In addition, although TGF-beta 1 treatment can increase Treg differentiation, it does not affect HIV infection rates.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biology
Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M. Taketo, Yousuke Takahama, Shinji Takada
Summary: The thymic epithelium plays a crucial role in supporting the development of T cells. This study found that enhanced expression of beta-catenin in thymic epithelial cells leads to thymic dysplasia and T cell deficiency in the embryonic period, while loss of beta-catenin function only slightly reduces cortical thymic epithelial cells and thymocytes in postnatal development.
Article
Immunology
Han He, Yingpeng Yao, Lindong Tang, Yuhui Li, Zongcheng Li, Bing Liu, Yu Lan
Summary: In this study, the researchers performed single-cell analyses of thymocytes at different developmental stages and identified distinct subsets of prenatal CD4-CD8-double-negative (DN) cells responsible for T-cell lineage commitment. They found significant differences in gene expressions between prenatal and postnatal DN cells, indicating transcriptional heterogeneity during T-cell development. The study also revealed a dynamic landscape of alternative polyadenylation across T-cell development, providing insights into T lymphopoiesis in human thymus.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Emilie Brule, Ying Wang, Yining Li, Yeu-Farn Lin, Xiang Zhou, Luisina Ongaro, Carlos A. Alonso, Evan R. S. Buddle, Alan L. Schneyer, Chang-Hyeock Byeon, Cynthia S. Hinck, Natalia Mendelev, John P. Russell, Mitra Cowan, Ulrich Boehm, Frederique Ruf-Zamojski, Michel Zamojski, Cynthia L. Andoniadou, Stuart C. Sealfon, Craig A. Harrison, Kelly L. Walton, Andrew P. Hinck, Daniel J. Bernard
Summary: The study reveals TGFBR3L as the co-receptor for inhibin B, playing a crucial role in regulating FSH levels and ovarian follicle development. TGFBR3L has specific binding ability to inhibin B, with its knockdown or overexpression affecting inhibin B activity.
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Angela Etayo, Kai K. Lie, Reidun M. Bjelland, Ivar Hordvik, Aina-Cathrine Overgard, Oystein Saele
Summary: Marine fish larvae, including farmed ballan wrasse, often experience high mortality in early life stages unrelated to predation. It is crucial to understand the development and function of the adaptive immune system, as well as the role of nutrition, in order to establish effective preventive measures and expand the knowledge on immune system in lower vertebrates. The thymus development in ballan wrasse was observed for the first time at larval stage 3 and lymphoid at stage 5. T-cell maturation processes in ballan wrasse are similar to other teleosts, with a higher abundance of CD4-1+ cells indicating the prominent role of helper T-cells during development. Nutritional factors such as DHA/EPA, Zn, and Se may influence the expression of T-cell markers and thymus size, suggesting an earlier onset of adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Manuel M. Vicente, Ines Alves, Angela Fernandes, Ana M. Dias, Beatriz Santos-Pereira, Elena Perez-Anton, Sofia Santos, Tao Yang, Alexandra Correia, Anja Muenster-Kuehnel, Afonso R. M. Almeida, Sarina Ravens, Gabriel A. Rabinovich, Manuel Vilanova, Ana E. Sousa, Salome S. Pinho
Summary: The development of T-cells is regulated by glycosylation, which plays an important role in immune function and disease susceptibility. By studying the glycome compositions and dynamic alterations in human and murine thymocytes, it was discovered that high-mannose glycosylation is crucial for normal T-cell development. Specific glycoengineered mouse models further demonstrated that mannosylated thymocytes lead to developmental defects and increased susceptibility to inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cell Biology
Pedro M. Rodrigues, Laura G. Sousa, Chiara Perrod, Ana R. Maceiras, Pedro Ferreirinha, Rita Pombinho, Gema Romera-Cardenas, Maria Gomez-Lazaro, Meryem Senkara, Jelena Pistolic, Didier Cabanes, Ludger Klein, Paul Saftig, Nuno L. Alves
Summary: Thymic epithelial cells (TECs) are crucial for T cell development. This study reveals that lysosomal-associated membrane protein 2 (LAMP2) is highly expressed in cortical TECs (cTECs) and plays a role in autophagy and lysosomal processes. Genetic inactivation of Lamp2 in cTECs impairs the development of CD4 T cells without directing MHC II-restricted cells into the CD8 lineage. The findings suggest that LAMP2 is important for the generation of selecting self-peptides:MHC II complexes in cTECs.
Article
Immunology
A. Comas-Garcia, C. P. Lopez-Pacheco, E. A. Garcia-Zepeda, G. Soldevila, P. Ramos-Martinez, J. Ramos-Castaneda
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2016)
Article
Cell Biology
C. Lopez-Pacheco, G. Soldevila, G. Du Pont, R. Hernandez-Pando, E. A. Garcia-Zepeda
MEDIATORS OF INFLAMMATION
(2016)
Article
Multidisciplinary Sciences
Carlos A. Mier-Aguilar, Kevin S. Cashman, Chander Raman, Gloria Soldevila
Article
Immunology
Evelyn Katy Alvarez Salazar, Arimelek Cortes-Hernandez, German Rodrigo Aleman-Muench, Josefina Alberu, Jesus R. Rodriguez-Aguilera, Felix Recillas-Targa, Victoria Chagoya de Sanchez, Eric Cuevas, Eduardo Mancilla-Urrea, Maria Perez Garcia, Guillermo Mondragon-Ramirez, Mario Vilatoba, Ian Bostock, Erick Hernandez-Mendez, David De Rungs, Eduardo A. Garcia-Zepeda, Gloria Soldevila
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Roxana Olguin-Alor, Marisol de la Fuente-Granada, Laura C. Bonifaz, Laura Antonio-Herrera, Eduardo A. Garcia-Zepeda, Gloria Soldevila
Article
Immunology
Laura Antonio-Herrera, Oscar Badillo-Godinez, Oscar Medina-Contreras, Araceli Tepale-Segura, Alberto Garcia-Lozano, Lourdes Gutierrez-Xicotencatl, Gloria Soldevila, Fernando R. Esquivel-Guadarrama, Juliana Idoyaga, Laura C. Bonifaz
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Agriculture, Dairy & Animal Science
Ismael Martinez-Cortes, Naray A. Acevedo-Dominguez, Roxana Olguin-Alor, Arimelek Cortes-Hernandez, Violeta Alvarez-Jimenez, Marcia Campillo-Navarro, Hector S. Sumano-Lopez, Lilia Gutierrez-Olvera, Daniel Martinez-Gomez, Jose L. Maravillas-Montero, Juan J. Loor, Eduardo A. Garcia-Zepeda, Gloria Soldevila
JOURNAL OF ANIMAL SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Marisol de la Fuente-Granada, Roxana Olguin-Alor, Sandra Ortega-Francisco, Laura C. Bonifaz, Gloria Soldevila
Review
Cell Biology
Erica Burgueno-Bucio, Carlos A. Mier-Aguilar, Gloria Soldevila
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Oncology
Abril Saint-Martin, Jacobo Martinez-Rios, M. Cristina Castaneda-Patlan, Miguel Angel Sarabia-Sanchez, Nydia Tejeda-Munoz, Alberto Chinney-Herrera, Gloria Soldevila, Roberto Benelli, Paula Santoyo-Ramos, Alessandro Poggi, Martha Robles-Flores
Article
Multidisciplinary Sciences
Hui Li, Erica Burgueno-Bucio, Shin Xu, Shaonli Das, Roxana Olguin-Alor, Craig A. Elmets, Mohammad Athar, Chander Raman, Gloria Soldevila, Hui Xu
Article
Cell Biology
A. Cortes-Hernandez, E. Alvarez-Salazar, S. Arteaga-Cruz, J. Alberu-Gomez, G. Soldevila
CELLULAR IMMUNOLOGY
(2020)
Article
Immunology
Evelyn Katy Alvarez-Salazar, Arimelek Cortes-Hernandez, Saul Arteaga-Cruz, Josefina Alberu-Gomez, Gloria Soldevila
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Aleida Nunez-Ruiz, Flor Sanchez-Brena, Cynthia Lopez-Pacheco, Naray A. Acevedo-Dominguez, Gloria Soldevila
Summary: There is a strong correlation between obesity and an increased risk of breast cancer. Obesity can promote tumor growth through inducing systemic alterations of the immune cell homeostasis. The interaction between adipocytes, cancer cells, and immune cells plays a role in breast cancer development in obesity.
Article
Biochemistry & Molecular Biology
Sandra Ortega-Francisco, Marisol de la Fuente-Granada, Evelyn K. Alvarez Salazar, Lizbeth Airais Bolanos-Castro, Gabriela Fonseca-Camarillo, Roxana Olguin-Alor, German R. Aleman-Muench, Fernando Lopez-Casillas, Chander Raman, Eduardo A. Garcia-Zepeda, Gloria Soldevila
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
