Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
出版年份 2012 全文链接
标题
Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone
作者
关键词
-
出版物
PLoS One
Volume 7, Issue 7, Pages e39131
出版商
Public Library of Science (PLoS)
发表日期
2012-07-03
DOI
10.1371/journal.pone.0039131
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders
- (2011) Romano Di Fabio et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist
- (2011) Christopher J. Winrow et al. JOURNAL OF NEUROGENETICS
- Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep
- (2011) M. Mieda et al. JOURNAL OF NEUROSCIENCE
- Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia
- (2011) Christopher J. Winrow et al. NEUROPHARMACOLOGY
- Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists
- (2011) Alessandro Gozzi et al. PLoS One
- Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
- (2010) Paul J. Coleman et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin
- (2010) Eugene Nattie et al. JOURNAL OF APPLIED PHYSIOLOGY
- Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
- (2010) Christopher D. Cox et al. JOURNAL OF MEDICINAL CHEMISTRY
- State-dependent central chemoreception: A role of orexin
- (2010) Tomoyuki Kuwaki et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Orexin neurons as arousal-associated modulators of central cardiorespiratory regulation
- (2010) Tomoyuki Kuwaki et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor
- (2009) P Malherbe et al. BRITISH JOURNAL OF PHARMACOLOGY
- Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats
- (2009) David B. Whitman et al. ChemMedChem
- Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
- (2009) C. Dugovic et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- A key role for orexin in panic anxiety
- (2009) Philip L Johnson et al. NATURE MEDICINE
- The hypocretins as sensors for metabolism and arousal
- (2008) Antoine Adamantidis et al. JOURNAL OF PHYSIOLOGY-LONDON
- RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
- (2008) Theresa M. Ballard et al. PSYCHOPHARMACOLOGY
- Orexinergic modulation of breathing across vigilance states
- (2008) Tomoyuki Kuwaki RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs
- (2007) Kristian Linnet et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now