Article
Immunology
Mary Darby Jackson, Sandy M. Wong, Brian J. Akerley
Summary: NTHi utilizes sialic acid to evade host immune defenses and sialylation protects NTHi glycan structures from IgM and complement-mediated killing. Sialylation of LOS reduced the survival of siaB mutant in the murine lung due to decreased IgM binding, highlighting the importance of this evasion strategy in NTHi infection.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Justin T. H. Chan, Amparo Picard-Sanchez, Jovana Majstorovic, Alexander Rebl, Dirk Koczan, Filip Dycka, Astrid S. Holzer, Tomas Korytar
Summary: The presence of pathogen antibodies on red blood cells of infected rainbow trout indicates that red blood cells play a larger role in host immunity than previously appreciated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Johannes S. Gach, Stephanie Y. Matsuno, Mayalen Mercado, Lars Hangartner, Donald N. Forthal
Summary: The low abundance of envelope spikes and the inability of IgG to aggregate virions make HIV-1 a poor target for antibody-mediated clearance. However, by generating multimers of the neutralizing antibody VRC01 and introducing complement, the internalization of HIV-1 virions can be improved, providing a potential therapeutic approach to clearing the virus.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arya Ghate, Samriddhi Sharma, Palak Agrawal, Arvind Sahu
Summary: Macrophages polarize into different functional phenotypes - M1 and M2 - each expressing distinct complement receptors. While M1 cells show increased expression of CR1/2 and M2 cells exhibit higher expression of CR4, CR3 is equally expressed on both phenotypes. These complement receptor expression patterns can aid in better locating a macrophage along its phenotypic spectrum when combined with other known polarization markers.
MOLECULAR IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hanmant Gaikwad, Yue Li, Guankui Wang, Ronghui Li, Shaodong Dai, Cody Rester, Ross Kedl, Laura Saba, Nirmal K. Banda, Robert Scheinman, Casey Patrick, Krishna M. G. Mallela, S. Moein Moghimi, Dmitri Simberg
Summary: This study investigates the role of neutralizing antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 in complement activation and opsonization. The researchers found that anti-RBD antibodies can fix complement, but each antibody has limited ability to bind complement. Additionally, complement-dependent uptake was only observed in vaccinated donors with high anti-RBD titers.
Article
Immunology
Edward B. Irvine, Anthony O'Neil, Patricia A. Darrah, Sally Shin, Alok Choudhary, Wenjun Li, William Honnen, Smriti Mehra, Deepak Kaushal, Hannah Priyadarshini Gideon, JoAnne L. Flynn, Mario Roederer, Robert A. Seder, Abraham Pinter, Sarah Fortune, Galit Alter
Summary: Alter and colleagues demonstrate that IgM titers in plasma and bronchoalveolar lavage fluid are markers of reduced Mtb burden in rhesus macaques vaccinated intravenously with Bacille Calmette-Guerin. This study suggests the potential importance of IgM responses as a marker and mediator of protection against TB, highlighting the superior antibody responses induced by intravenous BCG compared to traditional intradermal administration.
Article
Microbiology
Valentina A. Schmidt, Victoria Rose Stevens, Javan Esfandiari, Konstantin P. Lyashchenko
Summary: This study has demonstrated that staphylococcal protein A employed for antibody detection in rapid point-of-care tests can capture not only IgG antibodies but also IgM antibodies, which may facilitate the identification of acute-stage HIV and syphilis infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Dongpeng Jiang, Haiwen Huang, Huimin Qin, Koukou Tang, Xiangru Shi, Tingting Zhu, Yuqing Gao, Ying Zhang, Xiaopeng Tian, Jianhong Fu, Weiwei Qu, Weilan Cai, Yang Xu, Depei Wu, Jianhong Chu
Summary: BCMA-targeting CAR-T therapy has shown promising responses in MM, but alternative targets are needed for BCMA-deficient tumors and BCMA antigen-loss relapse. This study reveals that FcRH5 is expressed on MM cells and can be targeted with CAR-T cells. FcRH5 CAR-T cells exhibit antigen-specific activation, cytokine secretion, and cytotoxicity against MM cells, and show robust tumoricidal efficacy in mouse models. FcRH5/BCMA-bispecific CAR-T cells demonstrate improved efficacy compared to mono-specific CAR-T cells.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Wilfried Posch, Marta Bermejo-Jambrina, Marion Steger, Christina Witting, Gabriel Diem, Paul Hoertnagl, Hubert Hackl, Cornelia Lass-Floerl, Lukas A. Huber, Teunis B. H. Geijtenbeek, Doris Wilflingseder
Summary: Complement-opsonized HIV-1 triggers efficient antiviral responses in dendritic cells by activating multiple signaling pathways. Complement plays a crucial role in inducing effective antiviral immune responses by preventing HIV-1 suppressive mechanisms and activating specific cytosolic sensors.
Article
Oncology
Beatrice T. Wang, Tasnim Kothambawala, Ling Wang, Thomas J. Matthew, Susan E. Calhoun, Avneesh K. Saini, Maya F. Kotturi, Genevive Hernandez, Eric W. Humke, Marvin S. Peterson, Angus M. Sinclair, Bruce A. Keyt
Summary: IGM-8444, an engineered multivalent agonistic IgM antibody with high avidity to DR5, induces cancer cell apoptosis through efficient DR5 multimerization. It shows potent cytotoxicity in a broad range of solid and hematologic cancer cell lines, and exhibits synergistic effects when combined with chemotherapy or BCL-2 inhibition, without increasing hepatotoxicity, supporting its clinical development in cancer therapy.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Immunology
Sian E. Jossi, Melissa Arcuri, Areej Alshayea, Ruby R. Persaud, Edith Marcial-Juarez, Elena Palmieri, Roberta Di Benedetto, Marisol Perez-Toledo, Jamie Pillaye, Will M. Channell, Anna E. Schager, Rachel E. Lamerton, Charlotte N. Cook, Margaret Goodall, Takeshi Haneda, Andreas J. Baumler, Lucy H. Jackson-Jones, Kai-Michael Toellner, Calman A. MacLennan, Ian R. Henderson, Francesca Micoli, Adam F. Cunningham
Summary: Vi-specific IgM or IgG can independently protect against infection, and superior protection from vaccination with TCV in adults may be related to the ability of the response to persist better.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jeromine Klingler, Gregory S. Lambert, Vincenza Itri, Sean Liu, Juan C. Bandres, Gospel Enyindah-Asonye, Xiaomei Liu, Viviana Simon, Charles R. Gleason, Giulio Kleiner, Hsin-Ping Chiu, Chuan-Tien Hung, Shreyas Kowdle, Fatima Amanat, Benhur Lee, Susan Zolla-Pazner, Chitra Upadhyay, Catarina E. Hioe
Summary: This study examined antibody responses in plasma and saliva after vaccination or infection, finding a significant correlation between the two despite differences in Ig isotypes. Plasma antibodies demonstrated comparable neutralization and antibody-dependent cellular phagocytosis (ADCP) potencies, but vaccination induced a greater capacity to activate complement compared to convalescent individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Iara Maira de Oliveira Viana, Sabrina Roussel, Joan Defrene, Eliana Martins Lima, Frederic Barabe, Nicolas Bertrand
Summary: Significant progress has been made in the field of nanomedicine, allowing for more efficient drug delivery and recognition of therapeutic effects through a collaboration of engineering and medicine. Successes in gene silencing methods beyond oncology have paved the way for new therapies. The global pandemic has highlighted the potential of mRNA vaccines, emphasizing the need for rational design of therapies and vaccines in the future.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Dermatology
Daniel Leonard Seiler, Marie Kleingarn, Katja Hendrika Kahler, Caroline Gruner, Jovan Schanzenbacher, Elvira Ehlers-Jeske, Samyr Kenno, Christian David Sadik, Enno Schmidt, Katja Bieber, Jorg Kohl, Ralf J. Ludwig, Christian Marcel Karsten
Summary: This study reveals the proinflammatory role of C5aR2 in the pathogenesis of antibody-induced tissue damage in epidermolysis bullosa acquisita (EBA).
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Jo-Lewis Banga Ndzouboukou, Yan-di Zhang, Qing Lei, Xiao-song Lin, Zong-jie Yao, Hui Fu, Le-yong Yuan, Xiong-lin Fan
Summary: The study found that the IgG antibody responses elicited in healthy individuals after inactivated SARS-CoV-2 vaccination were significantly higher than IgM, and sex did not have an effect on the antibody response. Age and the detection time after the second dose of vaccination can influence the antibody levels.
CURRENT MEDICAL SCIENCE
(2021)
Article
Immunology
Joakim J. E. Bergstrom, Birgitta Heyman
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Joakim J. E. Bergstrom, Hui Xu, Birgitta Heyman
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Lu Zhang, Zhoujie Ding, Birgitta Heyman
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Hui Xu, Lu Zhang, Birgitta Heyman
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Allergy
Maya Salomonsson, Andrei Malinovschi, Pia Kalm-Stephens, Joakim S. Dahlin, Christer Janson, Kjell Alving, Jenny Hallgren
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Review
Immunology
Erika Mendez-Enriquez, Jenny Hallgren
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Allergy
Maya Salomonsson, Johanna Ungerstedt, Perla A. Alvarado-Vazquez, Jenny Hallgren
Article
Allergy
Jenny Hallgren, Lars Hellman, Marcus Maurer, Gunnar P. Nilsson, Sara Wernersson, Magnus Abrink, Gunnar Pejler
Article
Immunology
Maya Salomonsson, Joakim S. Dahlin, Johanna Ungerstedt, Jenny Hallgren
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Hui Xu, Birgitta Heyman
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Letter
Allergy
Perla A. Alvarado-Vazquez, Erika Mendez-Enriquez, Jenny Hallgren
Article
Allergy
Erika Mendez-Enriquez, Perla Abigail Alvarado-Vazquez, Willem Abma, Oscar E. Simonson, Sergey Rodin, Thorsten B. Feyerabend, Hans-Reimer Rodewald, Andrei Malinovschi, Christer Janson, Mikael Adner, Jenny Hallgren
Summary: This study found that mast cells release serotonin, which enhances bronchoconstriction and AHR. Mast cells play a key role in the pathogenesis of asthma, and M3-directed treatments may also act by targeting mast cells.
Letter
Allergy
Blondal Viiu, Janson Christer, Sundbom Fredrik, P. Borres Magnus, Hallgren Jenny, Tsolakis Nikolaos, Alving Kjell, Malinovschi Andrei
Article
Allergy
Erika Mendez-Enriquez, Maya Salomonsson, Jens Eriksson, Christer Janson, Andrei Malinovschi, Mikael E. Sellin, Jenny Hallgren
Summary: It has been found that mast cell progenitors can be activated by IgE cross-linking, which may contribute to the development of acute allergic airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)