Review
Biochemistry & Molecular Biology
Min-Jee Jo, Joo-Kyung Lee, Ji-Eun Kim, Gang-Jee Ko
Summary: The rapid growth of the elderly population has led to an increased need for extensive and advanced information on age-related organ dysfunction. The kidney, being one of the organs most affected by aging, experiences functional decline, including reduced size, decreased filtration rate, changes in blood flow, and increased inflammation and fibrosis. This review provides a foundation for understanding the functional and molecular mechanisms of aging kidneys and identifies potential targets for future treatments of age-related kidney issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, Vincenzo Papa, Sebastiano Gangemi
Summary: Atopic dermatitis is a chronic inflammatory skin disease where oxidative stress plays a key role. Phototherapy has immunomodulatory effects and reduces oxidative stress markers. Studying the impact of phototherapy on oxidative stress molecular pathways in atopic dermatitis-affected cells can lead to new drug treatment strategies.
Review
Chemistry, Multidisciplinary
Giuseppe Bardi, Luca Boselli, Pier Paolo Pompa
Summary: This review discusses the complex process of inflammation and the potential role of platinum nanozymes in reducing inflammation. By regulating ROS levels and clearing inflammatory mediators, platinum nanozymes can effectively decrease inflammation and have shown biocompatibility and immune compatibility.
Review
Chemistry, Multidisciplinary
Giuseppe Bardi, Luca Boselli, Pier Paolo Pompa
Summary: Inflammation is the body's response to pathogen infections or dysregulated metabolism, involving immune system components. Reactive Oxygen Species (ROS) play important roles in cell signaling and pathogen destruction, but excessive ROS can cause damage. Current anti-inflammatory therapies focus on inhibiting pro-inflammatory mediators, but increasing enzymatic activity to reduce ROS levels may be an alternative approach. Platinum-based nanozymes (PtNZs) have efficient catalytic functionalities and can reduce inflammation by scavenging ROS. In this review, we analyze inflammation triggers and the effects of PtNZs under inflammatory conditions and discuss potential design improvements to enhance their anti-inflammatory action.
Review
Pharmacology & Pharmacy
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale
Summary: Impairment in mitochondrial homeostasis plays a crucial role in sarcopenia, leading to loss of muscle mass and strength. Targeting mitochondrial defects and developing drug delivery systems show promising potential for prevention and treatment, but require further clinical studies for promotion.
Review
Biochemistry & Molecular Biology
Sean X. Gu, Sanjana Dayal
Summary: Aging is a major risk factor for various diseases, including cardiovascular disease. Reactive oxygen species and oxidative stress have been shown to play a role in age-related vascular diseases. Platelets, as key contributors in vascular disease progression, undergo oxidative changes that are associated with comorbid conditions such as diabetes, atherosclerosis, obesity, and cancer. Understanding the mechanistic links between oxidative stress and vascular diseases is crucial for developing targeted therapeutic strategies for age-associated vascular diseases.
Review
Cell Biology
Younis Ahmad Hajam, Raksha Rani, Shahid Yousuf Ganie, Tariq Ahmad Sheikh, Darakhshan Javaid, Syed Sanober Qadri, Sreepoorna Pramodh, Ahmad Alsulimani, Mustfa F. Alkhanani, Steve Harakeh, Arif Hussain, Shafiul Haque, Mohd Salim Reshi
Summary: This article discusses the mechanism of oxidative stress and its relationship with aging and related diseases.
Review
Pharmacology & Pharmacy
Xin-xing Yang, Rong Yang, Feng Zhang
Summary: Parkinson's disease is a common and chronic degenerative disease in the central nervous system. The main pathology involves the loss of dopaminergic neurons and the formation of Lewy bodies. The pathogenesis of PD is influenced by various independent factors, and regulating the Nrf2 pathway may be a promising strategy for preventing and treating PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Alzheimer's disease is the principal cause of dementia and is associated with neurodegenerative disorders. Hericium erinaceus, a nutritional mushroom with important antioxidant effects, has shown significant therapeutic effects in a rat model of AD, reducing behavioral changes and hippocampal neuronal degeneration.
Review
Food Science & Technology
Zhijun Yang, Dan-Dan Zhou, Si-Yu Huang, Ai-Ping Fang, Hua-Bin Li, Hui-Lian Zhu
Summary: Alzheimer's disease (AD) is the most common form of dementia in elderly people, and natural products and bioactive compounds have potential in preventing and treating AD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medicine, Research & Experimental
Kai Hu, Xiaozheng Yuan, Huan He, Hui Zhang, Fengsong Wang, Jing Qiao
Summary: This study demonstrates that chitotriose (COS) is a safe and effective therapeutic agent for experimental inflammatory bowel disease (IBD) as a redox regulator. COS effectively relieves inflammation, restores epithelial function, and reduces intestinal fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Sujit Kumar Bhutia
Summary: Vitamin D regulates cellular homeostasis through activating autophagy, protecting against oxidative stress and apoptosis, and inducing anticancer mechanisms. It also modulates inflammation and host immunity through autophagy signaling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Hussain Rao, Jonathan A. Jalali, Thomas P. Johnston, Peter Koulen
Summary: Diabetic retinopathy (DR) is a major cause of vision loss, with mechanisms involving triglyceride and cholesterol metabolism that require exploration of new therapeutic options. Analysis reveals that dysmetabolism of triglycerides and cholesterol, combined with diabetes, leads to clearer understanding of the pathogenesis of DR.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gianni Paulis, Giovanni De Giorgio, Luca Paulis
Summary: The article provides a narrative review of the current literature on antioxidant therapy for Peyronie's disease. The results demonstrate the positive effects of antioxidant treatment on the disease, although further randomized controlled studies are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Omar Hahad, Andreas Daiber, Matthias Michal, Marin Kuntic, Klaus Lieb, Manfred Beutel, Thomas Muenzel
Summary: Despite efforts to combat smoking, it remains a leading cause of morbidity and mortality globally. There is strong evidence linking smoking to increased risk of neuropsychiatric diseases, indicating the importance of addressing this relationship in public health policies and measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)