Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 99, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2021.108841
Keywords
Autophagy; Cancer; Inflammation; Immunity; Vitamin D; Oxidative stress
Funding
- Indian Council of Medical Research (ICMR) Govt. of India [5/13/20/2020/NCD-III]
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Vitamin D regulates cellular homeostasis through activating autophagy, protecting against oxidative stress and apoptosis, and inducing anticancer mechanisms. It also modulates inflammation and host immunity through autophagy signaling.
Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and epidemiological evidence establishes an association between vitamin D deficiency and various human diseases. Here, the role of autophagy, the cellular self-degradation process, in vitamin D-dependent function is documented in different cellular settings and discussed the molecular aspects for treating chronic inflammatory, infectious diseases, and cancer. Vitamin D activates autophagy through a genomic and non-genomic signaling pathway to influence a wide variety of physiological functions of different body organs along with bone health and calcium metabolism. Moreover, it induces autophagy as a protective mechanism to inhibit oxidative stress and apoptosis to regulate cell proliferation, differentiation, and immune modulation. Furthermore, vitamin D and its receptor regulate autophagy signaling to control inflammation and host immunity by activating antimicrobial defense mechanisms. Vitamin D has been revealed as a potent anticancer agent and induces autophagy to increase the response to radiation and chemotherapeutic drugs for potential cancer therapy. Increasing vitamin D levels in the human body through timely exposure to sunlight or vitamin D supplements could activate autophagy as part of the homeostasis mechanism to prevent multiple human diseases and aging-associated dysfunctions. (c) 2021 Elsevier Inc. All rights reserved.
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