Concomitant Targeting of EGF Receptor, TGF-beta and Src Points to a Novel Therapeutic Approach in Pancreatic Cancer

A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells

(2011) Lorenzo F. Sempere et al.   CANCER BIOLOGY & THERAPY

A Genome-Wide Association Study of Overall Survival in Pancreatic Cancer Patients Treated with Gemcitabine in CALGB 80303

(2011) F. Innocenti et al.   CLINICAL CANCER RESEARCH

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

(2011) N. S. Nagaraj et al.   CLINICAL CANCER RESEARCH

TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

(2011) Laurens A. van Meeteren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis

(2011) C A Whipple et al.   ONCOGENE

Kinase signaling pathways as targets for intervention in pancreatic cancer

(2010) Meir Preis et al.   CANCER BIOLOGY & THERAPY

Stromal biology and therapy in pancreatic cancer

(2010) A. Neesse et al.   GUT

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies

(2010) M. Mimeault et al.   PHARMACOLOGICAL REVIEWS

Transforming Growth Factor   Induces Clustering of HER2 and Integrins by Activating Src-Focal Adhesion Kinase and Receptor Association to the Cytoskeleton

(2009) S. E. Wang et al.   CANCER RESEARCH

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

Met and c-Src Cooperate to Compensate for Loss of Epidermal Growth Factor Receptor Kinase Activity in Breast Cancer Cells

(2008) K. L. Mueller et al.   CANCER RESEARCH

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Reversing Cancer From Inside and Out: Oncogene Addiction, Cellular Senescence, and the Angiogenic Switch

(2008) Dean W. Felsher   Lymphatic Research and Biology

LY2109761, a novel transforming growth factor   receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

(2008) D. Melisi et al.   MOLECULAR CANCER THERAPEUTICS

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE