Article
Endocrinology & Metabolism
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T. A. Lewis, Danial Ahwazi, Naomi X. Y. Ling, Jeppe K. Larsen, Atul S. Deshmukh, Mohammad A. Hossain, Jonathan S. Oakhill, Julien Ochala, Jeffrey J. Brault, Uma Sankar, David H. Drewry, John W. Scott, Carol A. Witczak, Kei Sakamoto
Summary: This study aimed to investigate the role of CaMKK2 in the activation of AMPK and glucose uptake in skeletal muscle following contractions. The results showed that the inhibition or genetic loss of CaMKK2 does not affect AMPK activation and glucose uptake.
MOLECULAR METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Ji Cao, Jingjing Zhang, Jianan Qian, Xue Wang, Wei Zhang, Xiangfan Chen
Summary: This study investigated the effect of RIPK3-regulated CaMKII on necroptosis in heart failure and its mechanism. The results showed that depletion of RIPK3 alleviated cardiac dysfunction, CaMKII activation, and necroptosis. These findings provide valuable insights into the pathogenesis and treatment strategy of heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Lise M. Sjogaard-Frich, Andreas Prestel, Emilie S. Pedersen, Marc Severin, Kristian Kolby Kristensen, Johan G. Olsen, Birthe B. Kragelund, Stine Falsig Pedersen
Summary: Through various biophysical techniques, this study reveals the complex interaction mechanism between CaM and NHE1, identifying multiple states and structures of the NHE1:CaM complex that can be modulated by stoichiometries, calcium concentrations, and phosphorylation. Experimental results suggest that CaM may enhance NHE1 regulation and indicate that this structural diversity is relevant to other CaM complexes as well.
Article
Environmental Sciences
Zhenjie Sun, Wenhui Gu, Zezhong Feng, Yaqin Fan, Jianfeng Niu, Guangce Wang
Summary: This study elucidated the expression regulation mechanism of the heat shock protein 70 gene in Neopyropia yezoensis under high temperature stress. The findings showed the involvement of cAMP-dependent protein kinase and activating transcription factors element in the transcription regulation of the gene. In addition, AMPK was also found to play a role in the induction of the gene. Furthermore, posttranscriptional mechanisms were proposed to be involved in the synthesis regulation of the heat shock protein 70-2 protein.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Tae-Jun Song, Choon-Ho Park, Kyu-Ree In, Jong-Bae Kim, Joo Hee Kim, Miran Kim, Hye Jin Chang
Summary: Betulinic acid (BA) is a naturally occurring compound with various biological effects including anti-malarial, anti-inflammatory, anti-cancer, and recently discovered anti-obesity and anti-diabetic activities. BA activates AMPK, leading to reduced blood glucose levels, increased glucose uptake, and enhanced endurance in mice, indicating its therapeutic potential for diabetes.
Article
Multidisciplinary Sciences
Naohiro Kon, Hsin-tzu Wang, Yoshiaki S. Kato, Kyouhei Uemoto, Naohiro Kawamoto, Koji Kawasaki, Ryosuke Enoki, Gen Kurosawa, Tatsuto Nakane, Yasunori Sugiyama, Hideaki Tagashira, Motomu Endo, Hideo Iwasaki, Takahiro Iwamoto, Kazuhiko Kume, Yoshitaka Fukada
Summary: Temperature compensation of circadian rhythms is achieved through NCX-mediated Ca2+ signaling, which plays essential roles in maintaining temperature-compensated oscillations.
Article
Biochemistry & Molecular Biology
Michal Marcinkowski, Tomas Pilzys, Damian Garbicz, Jan Piwowarski, Kaja Przygonska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jaroslaw Poznanski, Elzbieta Grzesiuk
Summary: FTO is an N-6-methyladenosine demethylase which can remove methyl groups from nucleic acids, forming complexes with other proteins. Research indicates an interaction between FTO and calmodulin (CaM), influencing calcium-binding loops in CaM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Premchand Rajeev, Nivedita Singh, Adel Kechkar, Cory Butler, Narendrakumar Ramanan, Jean-Baptiste Sibarita, Mini Jose, Deepak Nair
Summary: Synapse associated protein-97/Human Disk Large (SAP97/hDLG) is a conserved, alternatively spliced, modular, scaffolding protein critical in regulating the molecular organization of cell-cell junctions in vertebrates. The molecular determinants of first order phase transition of SAP97/hDLG is controlled by morpho-functional changes in its nanoscale organization. Additionally, the nanoscale molecular signatures of these signaling islands and phase transitions are altered in response to changes in cytosolic Ca2+, showing differential sensitivities to Ca2+ bound Calmodulin. SAP97/hDLG forms nanosized molecular domains in both heterologous cells and hippocampal pyramidal neurons, with molecular signatures and exchange kinetics being modulated by the availability of alternatively spliced isoforms.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Anastasiia Bohush, Wieslawa Lesniak, Serge Weis, Anna Filipek
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the formation of Lewy bodies and loss of dopaminergic neurons. Changes in intracellular Ca2+ levels can have serious consequences on cells, with calmodulin playing a crucial role in regulating neuronal plasticity. Therefore, alterations in the activity of calmodulin and its binding proteins may be linked to the development and progression of PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Yan Zou, Miaomiao Zhang, Qiongfeng Wu, Ning Zhao, Minwei Chen, Cui Yang, Yimei Du, Bing Han
Summary: This study demonstrates that TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy and dysfunction through the Ca2+/CaMKII mediated activation of NF kappa B-NLRP3. Therefore, TRPV4 may represent a potential therapeutic drug target for cardiac hypertrophy and dysfunction after pressure overload.
Article
Biochemistry & Molecular Biology
Tzu-Kang Lin, Chi-Feng Hung, Jing-Ru Weng, Ting-Yang Hsieh, Su-Jane Wang
Summary: This study found that Kaempferol 3-rhamnoside (KR) can inhibit 4-aminopyridine (4-AP)-evoked glutamate release. The inhibitory effect of KR is linked to the omission of external Ca2+ or the depletion of glutamate in synaptic vesicles, as well as the suppression of P/Q-type Ca2+ channel activity. Additionally, KR reduces the increase in Ca2+ concentration and the phosphorylation of CaMKII and its substrate synapsin I.
Article
Cell Biology
Jee Young Sohn, Hyeok-Jin Kwak, Ji Heon Rhim, Eui-Ju Yeo
Summary: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme that plays a role in cellular events such as DNA repair and apoptosis. This study suggests that increased AMP-activated protein kinase (AMPK) activity may be involved in the nuclear translocation of GAPDH in senescent cells.
Review
Endocrinology & Metabolism
Pamela Gaitan-Gonzalez, Rommel Sanchez-Hernandez, Jose-Antonio Arias-Montano, Angelica Rueda
Summary: Metabolic syndrome is a pre-diabetic state characterized by insulin resistance, visceral fat accumulation, and dyslipidemias, which increase the risk for developing cardiovascular disease. Increased synergistic tone in metabolic syndrome may contribute to the onset of pre-diabetic cardiomyopathy. The alterations in protein kinase A and Ca2+/calmodulin-dependent protein kinase II play important roles in functional responses mediated by beta(1)-adrenoceptors in pre-diabetes.
WORLD JOURNAL OF DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Hamish Stevens-Bullmore, Don Kulasiri, Sandhya Samarasinghe
Summary: This paper mathematically models the activation of CaM by Ca2+ and the binding of CaM to downstream proteins. The study found that under high stimulation, CaM redistributes from low-affinity to high-affinity binding targets and represses activation of opposing CaM-binding proteins. The model also discovered that CaMKII can repress cAMP production by repressing CaM-regulated proteins. Under low levels of Ca2+ stimulation, CaM signaling is unstable and unlikely to induce synaptic depression alone.
Article
Neurosciences
Cecile Hryhorczuk, Marc Florea, Demetra Rodaros, Isabelle Poirier, Caroline Daneault, Christine Des Rosiers, Andreas Arvanitogiannis, Thierry Alquier, Stephanie Fulton
NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Behavioral Sciences
Lionel Budry, Khalil Bouyakdan, Stephanie Tobin, Demetra Rodaros, Ann-Britt Marcher, Susanne Mandrup, Stephanie Fulton, Thierry Alquier
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Cell Biology
Alexandre Fisette, Stephanie Tobin, Lea Decarie-Spain, Khalil Bouyakdan, Marie-Line Peyot, S. R. Murthy Madiraju, Marc Prentki, Stephanie Fulton, Thierry Alquier
Article
Endocrinology & Metabolism
Anindya Ghosh, Shaaban Abdo, Shuiling Zhao, Chin-Han Wu, Yixuan Shi, Chao-Sheng Lo, Isabelle Chenier, Thierry Alquier, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S. D. Chan
Article
Neurosciences
Cecile Hryhorczuk, Zhenyu Sheng, Lea Decarie-Spain, Nicolas Giguere, Charles Ducrot, Louis-Eric Trudeau, Vanessa H. Routh, Thierry Alquier, Stephanie Fulton
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Endocrinology & Metabolism
Lea Decarie-Spain, Sandeep Sharma, Cecile Hryhorczuk, Victor Issa-Garcia, Philip A. Barker, Nathalie Arbour, Ihierry Alquier, Stephanie Fulton
MOLECULAR METABOLISM
(2018)
Editorial Material
Neurosciences
Stephanie Fulton, Thierry Alquier
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Endocrinology & Metabolism
Valentine S. Moulle, Caroline Tremblay, Anne-Laure Castell, Kevin Vivot, Melanie Ethier, Grace Fergusson, Thierry Alquier, Julien Hislain, Vincent Poitout
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Article
Medicine, Research & Experimental
Khalil Bouyakdan, Hugo Martin, Fabienne Lienard, Lionel Budry, Bouchra Taib, Demetra Rodaros, Chloe Chretien, Eric Biron, Zoe Husson, Daniela Cota, Luc Penicaud, Stephanie Fulton, Xavier Fioramonti, Thierry Alquier
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Review
Endocrinology & Metabolism
Romane Manceau, Danie Majeur, Thierry Alquier
Article
Acoustics
Marc Gesnik, Manish Bhatt, Marie-Helene Roy Cardinal, Francois Destrempes, Louise Allard, Bich N Nguyen, Thierry Alquier, Jean-Francois Giroux, An Tang, Guy Cloutier
ULTRASOUND IN MEDICINE AND BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Genevieve Demers, Jerome Roy, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Caroline Daneault, Christine Des Rosiers, Guillaume Ferreira, Thierry Alquier, Stephanie Fulton
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Neurosciences
Caitlin Menzies, Shama Naz, David Patten, Thierry Alquier, Brian M. Bennett, Baptiste Lacoste
Summary: This study provides the first characterization and comparison of basal metabolism in three mouse models of NDDs, showing that each mouse model exhibits a unique metabolic signature that is sex-specific, independent of food consumption, and minimally influenced by physical activity. The findings highlight the importance of understanding NDD-associated metabolic alterations for future preclinical and clinical interventions.
Article
Endocrinology & Metabolism
Khalil Bouyakdan, Romane Manceau, Josephine L. Robb, Demetra Rodaros, Stephanie Fulton, Thierry Alquier
Summary: Astroglial ACBP has an important role in regulating energy balance and feeding. Deletion of ACBP in astrocytes can lead to hyperphagia and diet-induced obesity, while overexpression can reduce feeding and body weight. However, experiments show that deleting ACBP in astrocytes does not affect weight loss during transition from a high fat diet to a chow diet in obese mice, nor the metabolic parameters in mice fed with a normal chow diet. However, it does impair meal pattern and feeding responses during refeeding after a fast and during cold exposure. These findings challenge the previous view that astroglial ACBP has anorectic effects and suggest that the regulation of feeding by ACBP depends on metabolic status.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Thierry Alquier, Vincent Poitout