Article
Clinical Neurology
Zhu Sha, Shi Jing, Gao Feng, Hongjun Hao, Xianzeng Liu
Summary: A case of neurosyphilis with positive anti-NMDAR antibody was reported in a 54-year-old man with acute memory deficits. The patient was initially diagnosed with acute ischemic stroke (AIS) and treated with rt-PA, but episodic memory and orientation disorder persisted. Positive results for syphilis and elevated leukocyte count and protein level in cerebrospinal fluid (CSF) were found. The patient was ultimately diagnosed with neurosyphilis with positive anti-NMDAR antibody and showed improvement with treatment.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Marian Galovic, Adam Al-Diwani, Umesh Vivekananda, Matthew C. Walker, Sarosh R. Irani, Matthias J. Koepp, NEST Investigators
Summary: This study investigates the changes in N-methyl-d-aspartate receptor (NMDAR) density during the recovery from NMDAR-antibody encephalitis using a radiotracer and positron emission tomography.
Review
Chemistry, Medicinal
Amir Parsa Abhari, Masoud Etemadifar, Niloufar Yazdanpanah, Nima Rezaei
Summary: N-methyl-D-aspartate receptors (NMDARs) play a crucial role in regulating physiological processes in the brain and nervous system. Dysfunction of NMDARs can contribute to various pathologies, including cell death and brain dysfunction. Research has shown the significant involvement of NMDARs in demyelinating disorders and anti-NMDAR encephalitis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Neurosciences
Xi Zhao, Yuou Teng, Jingnian Ni, Ting Li, Jing Shi, Mingqing Wei
Summary: This study analyzed the clinical characteristics and prognostic factors of patients with anti-NMDAR encephalitis. Most patients had prodromal symptoms of about 2 weeks, including psychiatric symptoms, flu-like symptoms, and seizures. Poor prognoses were associated with autonomic instability, central hypoventilation, and ICU support. Older patients were more likely to develop central hypoventilation, cognitive impairment, and memory impairment, while younger patients were more likely to have seizures. The IVGC+IVIG treatment regimen resulted in better prognoses.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Pediatrics
Shiqi Guang, Jiannan Ma, Xiaotun Ren, Shuizhen Zhou, Jian Yang, Jianzhao Zhang, Xiaoshuang Cao, Linxiu Zhong, Xiao Ding, Xiaosu Wang, Changhong Ren, Weihua Zhang, Linmei Zhang, Min Zhang, Jing Sun, Miriam Kessi, Fei Yin, Jing Peng, Yuwu Jiang
Summary: This study focused on pediatric patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and suggested that second-line immunotherapy should be considered for patients with mRS >= 4 after first-line treatment and those with concomitantly positive MOG-Ab. Repetitive first-line immunotherapy can be an alternative when second-line treatment is not feasible, and both strategies help reduce relapse rates.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Nicolas Lundahl Ciano-Petersen, Pablo Cabezudo-Garcia, Sergio Muniz-Castrillo, Jerome Honnorat, Pedro Jesus Serrano-Castro, Begona Oliver-Martos
Summary: Discovery of biomarkers in rare diseases, like anti-NMDAR encephalitis, is crucial for better diagnosis, prognosis, and treatment development. Clinical and paraclinical markers are widely explored, while soluble molecules are proposed as biomarkers for clinical activity, inflammation, prognosis, and treatment response, requiring further studies for clinical validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Hanyu Luo, Xiao Ding, Yuhang Li, Jiannan Ma, Benke Liu, Lvli Zhou, Yaxin Zheng, Yan Jiang, Xiujuan Li, Li Jiang
Summary: This study analyzed the clinical characteristics of children with anti-NMDAR encephalitis after Japanese encephalitis (JE). The findings suggest that the clinical manifestation of anti-NMDAR encephalitis after JE may differ from classical anti-NMDAR encephalitis, and the prognosis is worse.
PEDIATRIC NEUROLOGY
(2022)
Review
Neurosciences
Bin Dong, Yang Yue, Han Dong, Yuehui Wang
Summary: NMDA receptors play a critical role in synaptic transmission and plasticity, and abnormalities in their expression and function can result in neurological disorders. NMDAR hypofunction is widely implicated in several disorders and is associated with disease progression and manifestation. Targeting NMDAR hypofunction could be a promising therapeutic approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Faruk Ekinci, Dincer Yildizdas, Ozden Ozgur Horoz, Ahmet Yontem, Gulen Gul Mert
Summary: In pediatric patients with anti-NMDAR encephalitis, pulmonary embolism should be considered as a potential cause of respiratory insufficiency, along with other symptoms such as altered consciousness, breathing instability, hypersalivation, status epilepticus, or dystonia, and appropriate treatment should be provided.
POSTGRADUATE MEDICINE
(2021)
Article
Clinical Neurology
Xue Gong, Rong Luo, Jie Liu, Kundian Guo, Aiqing Li, Xu Liu, Yue Liu, Dong Zhou, Zhen Hong
Summary: This study compared the effectiveness and safety of different treatment strategies as initial therapy for anti-NMDAR encephalitis. The results showed that combined treatment with IVIg and IVMP had a higher response rate, improved Rankin Scale scores, and lower recurrence rate compared to either IVIg or IVMP monotherapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sara de la Salle, Joelle Choueiry, Judy McIntosh, Hayley Bowers, Vadim Ilivitsky, Verner Knott
Summary: This study found that a subanesthetic dose of the NMDAR antagonist ketamine impaired auditory sensory gating, providing further evidence for the role of NMDAR hypofunction in schizophrenia.
PSYCHOPHARMACOLOGY
(2022)
Letter
Clinical Neurology
Zahra Vahabi, Farnaz Etesam, Atefeh Zandifar, Rahim Badrfam
Summary: Studies show that stress can affect the permeability of the blood-brain barrier, leading to an increase in NMDAR antibody positivity. Additionally, antibody-secreting cells in the intrathecal area of the brain can redistribute under various environmental stresses, further highlighting the role of environmental stress in Anti NMDAR encephalitis.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Hanyu Luo, Yuhang Li, Yaxin Zheng, Lvli Zhou, Jiaxin Yang, Zhixu Fang, Yan Jiang, Juan Wang, Zhengxiong Yao, Min Chen, Li Jiang
Summary: The NEOS score is a potentially reliable model to predict the one-year functional outcome in Chinese children with anti-NMDAR encephalitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Helena Arino, Ester Coutinho, Thomas A. Pollak, Robert Stewart
Summary: In a secondary mental health service, the positivity rate of NMDAR-IgG was low, with a positive predictive value for encephalitis around 50% in patients with chronic presentations and absence of other diagnostic criteria for encephalitis or autoimmune psychosis. Chronic neuropsychiatric problems in patients with anti-NMDAR encephalitis are not uncommon, highlighting the need for improved diagnostic and treatment strategies.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Hadi Zarif, Sarah Nicolas, Melanie Guyot, Salma Hosseiny, Anne Lazzari, Maria Magdalena Canali, Julie Cazareth, Frederic Brau, Valentine Golzne, Elisa Dourneau, Maud Maillaut, Carmelo Luci, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Douglas Daoudlarian, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Review
Medicine, Research & Experimental
Sarah Nicolas, Joelle Chabry, Alice Guyon, Hadi Zarif, Catherine Heurteaux, Agnes Petit-Paitel
M S-MEDECINE SCIENCES
(2018)
Article
Endocrinology & Metabolism
Hadi Zarif, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
NEUROIMMUNOMODULATION
(2019)
Article
Biotechnology & Applied Microbiology
Melanie Guyot, Thomas Simon, Franck Ceppo, Clara Panzolini, Alice Guyon, Julien Lavergne, Emilie Murris, Douglas Daoudlarian, Romain Brusini, Hadi Zarif, Sophie Abelanet, Sandrine Hugues-Ascery, Jean-Louis Divoux, Stephen J. Lewis, Arun Sridhar, Nicolas Glaichenhaus, Philippe Blancou
NATURE BIOTECHNOLOGY
(2019)
Article
Neurosciences
Helene Party, Cleo Dujarrier, Marie Hebert, Sophie Lenoir, Sara Martinez de Lizarrondo, Raphael Delepee, Claudine Fauchon, Marie-Christine Bouton, Pauline Obiang, Olivier Godefroy, Etienne Save, Laurent Lecardeur, Joelle Chabry, Denis Vivien, Veronique Agin
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2019)
Article
Endocrinology & Metabolism
Sarah Nicolas, Nathalie Rochet, Nadine Gautier, Joelle Chabry, Didier F. Pisani
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Neurosciences
Giovanne B. Diniz, Daniella S. Battagello, Marianne O. Klein, Bianca S. M. Bono, Jozelia G. P. Ferreira, Livia C. Motta-Teixeira, Jessica C. G. Duarte, Francoise Presse, Jean-Louis Nahon, Antoine Adamantidis, Melissa J. Chee, Luciane V. Sita, Jackson C. Bittencourt
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Microbiology
Patricia Bermudez-Martin, Jerome A. J. Becker, Nicolas Caramello, Sebastian P. Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurelia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joelle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic
Summary: The microbial metabolite p-Cresol induces ASD-like behavioral symptoms in mice, particularly social behavior deficits, and is associated with decreased activity of central dopamine neurons. These behavioral deficits induced by p-Cresol can be transferred via fecal microbiota transplantation and are dependent on changes in microbiota composition.
Article
Social Sciences, Interdisciplinary
Alice Guyon, Jerome Ravenet, Nancy Midol
Summary: The practices of Indian or Chinese energy arts face both taxonomic and axiological challenges, but contribute to bridging the gap between Western and Eastern scientific cultures and promoting sustainable sports through reconciling different paradigms.
STAPS-SCIENCES ET TECHNIQUES DES ACTIVITES PHYSIQUES ET SPORTIVES
(2021)
Article
Oncology
Maria Magdalena Canali, Melanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnes Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel, Masashi Kato, Evelyne Mougneau, Nicolas Glaichenhaus, Philippe Blancou
Summary: An enriched environment reduces lung metastasis in mice, potentially through the reprogramming of inflammatory monocytes and modulation of adrenergic receptors and glucocorticoid receptors signaling. This study highlights the complex role of inflammatory monocytes in cancer progression and suggests a novel anti-tumor mechanism associated with environmental factors.
CANCER CELL INTERNATIONAL
(2023)
Article
Ophthalmology
Mathieu Marconi, Christophe Zimmer, Noelia Do Carmo Blanco, Alice Guyon
Summary: Eyes constantly move to optimize the brain's interpretation of visual scenes. Eye movements are controlled by complex neural networks and can be influenced by cognitive activity. The Neuro Linguistic Programming theory associates gaze directions with specific mental tasks, but few studies have examined its validity.
JOURNAL OF EYE MOVEMENT RESEARCH
(2023)
Article
Neurosciences
Hadi Zarif, Selma Hosseiny, Agnes Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Julie Cazareth, Anne Lazzari, Catherine Heurteaux, Nicolas Glaichenhaus, Joelle Chabry, Alice Guyon, Agnes Petit-Paitel
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2018)