Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90

Determination of the volume changes induced by ligand binding to heat shock protein 90 using high-pressure denaturation

(2011) Zigmantas Toleikis et al.   ANALYTICAL BIOCHEMISTRY

Design, synthesis, and evaluation of small molecule Hsp90 probes

(2011) Tony Taldone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms

(2010) Asta Zubrienė et al.   BIOPHYSICAL CHEMISTRY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding of the Hsp90 molecular chaperone reaches new heights

(2010) Cara K Vaughan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3β

(2009) Vanessa M. Banz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone

(2009) Inga Cikotiene et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hsp90 and co-chaperones twist the functions of diverse client proteins

(2009) Abbey Zuehlke et al.   BIOPOLYMERS

Geldanamycin and its anti-cancer activities

(2009) Yayoi Fukuyo et al.   CANCER LETTERS

Structure-Based and in silico Design of Hsp90 Inhibitors

(2009) Miriam Sgobba et al.   ChemMedChem

Measurement of Nanomolar Dissociation Constants by Titration Calorimetry and Thermal Shift Assay – Radicicol Binding to Hsp90 and Ethoxzolamide Binding to CAII

(2009) Asta Zubrienė et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

(2009) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

(2009) Kenneth H. Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

(2009) Pei-Pei Kung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heat Shock Protein 90: Inhibitors in Clinical Trials

(2009) Marco A. Biamonte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90

(2009) Sanjay Nilapwar et al.   JOURNAL OF MOLECULAR BIOLOGY

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Visualizing the twists and turns of a molecular chaperone

(2009) Len Neckers et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Hsp90 mosaic: a picture emerges

(2009) Matthias P Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions

(2009) D Walerych et al.   ONCOGENE

The complex dance of the molecular chaperone Hsp90

(2009) Len Neckers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure-based design of molecular cancer therapeutics

(2009) Rob L.M. van Montfort et al.   TRENDS IN BIOTECHNOLOGY

Discovery and development of heat shock protein 90 inhibitors

(2008) Tony Taldone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands

(2008) Piotras Cimmperman et al.   BIOPHYSICAL JOURNAL

Do enthalpy and entropy distinguish first in class from best in class?

(2008) E FREIRE   DRUG DISCOVERY TODAY

The Hsp90 Chaperone Machinery

(2008) Sebastian Karl Wandinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY