Journal
CHEMMEDCHEM
Volume 4, Issue 9, Pages 1399-1409Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200900256
Keywords
antitumor agents; chaperones; Hsp90; molecular modeling; structure-based drug design
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The molecular chaperone Hsp90 is responsible for activation and stabilization of several oncoproteins in cancer cells, and has emerged as an important target in cancer treatment because of this pivotal role. In recent years, interests have arisen around structure-based design of small molecules aimed at inhibiting the chaperone activity of Hsp90. In this review, we, illustrate the recent advances in structure-based and in silico strategies aimed at discovering and optimizing Hsp90 inhibitors.
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