Inflammasome-Mediated IL-1β Production in Humans with Cystic Fibrosis

Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease

(2014) C. J. Blohmke et al.   JOURNAL OF IMMUNOLOGY

Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection

(2011) S. LeibundGut-Landmann et al.   JOURNAL OF IMMUNOLOGY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Dysfunctional CFTR Alters the Bactericidal Activity of Human Macrophages against Pseudomonas aeruginosa

(2011) Paola Del Porto et al.   PLoS One

Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis

(2011) Claudio Sorio et al.   PLoS One

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

(2011) Ying Zheng et al.   PLoS Pathogens

Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR

(2010) Monica Averna et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis

(2010) Sarah E. Rzemieniak et al.   IMMUNOLOGY

Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms

(2010) Jon R. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR5 as an Anti-Inflammatory Target and Modifier Gene in Cystic Fibrosis

(2010) C. J. Blohmke et al.   JOURNAL OF IMMUNOLOGY

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages

(2010) Sheetal Kotrange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proinflammatory Phenotype and Increased Caveolin-1 in Alveolar Macrophages with Silenced CFTR mRNA

(2010) Yaqin Xu et al.   PLoS One

Expression of Wild-Type CFTR Suppresses NF-κB-Driven Inflammatory Signalling

(2010) Mairi J. Hunter et al.   PLoS One

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Cystic fibrosis

(2009) Brian P O'Sullivan et al.   LANCET

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

IL1Bpolymorphisms modulate cystic fibrosis lung disease

(2009) Hara Levy et al.   PEDIATRIC PULMONOLOGY

CFTR Is a Negative Regulator of NFκB Mediated Innate Immune Response

(2009) Neeraj Vij et al.   PLoS One

Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/−Mice

(2008) Emanuela M. Bruscia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Interleukin-1β in Murine Cigarette Smoke–Induced Emphysema and Small Airway Remodeling

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Airway Inflammation in Cystic Fibrosis

(2008) Arnon Elizur et al.   CHEST

Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis

(2008) T. A. Douglas et al.   EUROPEAN RESPIRATORY JOURNAL

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA