Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

The Role of Lysosomes in Limiting Drug Toxicity in Mice

(2010) R. A. Ndolo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Predicting resistance mutations using protein design algorithms

(2010) K. M. Frey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high content screening assay for identifying lysosomotropic compounds

(2010) Sashi Nadanaciva et al.   TOXICOLOGY IN VITRO

Iclaprim, a Novel Diaminopyrimidine for the Treatment of Resistant Gram-Positive Infections

(2009) Carrie A Sincak et al.   ANNALS OF PHARMACOTHERAPY

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques

(2009) A. A. Vickers et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

(2009) Kathleen M. Frey et al.   JOURNAL OF MOLECULAR BIOLOGY

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase

(2009) Kathleen M. Frey et al.   JOURNAL OF STRUCTURAL BIOLOGY

Role of Folate Antagonists in the Treatment of Methicillin-Resistant Staphylococcus aureus Infection

(2008) E. J. C. Goldstein et al.   CLINICAL INFECTIOUS DISEASES

Increasing telithromycin resistance among Streptococcus pyogenes in Europe

(2008) S. S. Richter et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure-Based Approach to the Development of Potent and Selective Inhibitors of Dihydrofolate Reductase fromCryptosporidium

(2008) David B. Bolstad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

(2008) Irith Wiegand et al.   Nature Protocols