Structural Insights from Binding Poses of CCR2 and CCR5 with Clinically Important Antagonists: A Combined In Silico Study

Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist

(2011) Changsheng Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binding Site Analysis of CCR2 Through In Silico Methodologies: Docking, CoMFA, and CoMSIA

(2011) Gugan Kothandan et al.   Chemical Biology & Drug Design

Homology modeling of human CCR5 and analysis of its binding properties through molecular docking and molecular dynamics simulation

(2010) Mohsen Shahlaei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ligand Based CoMFA, CoMSIA and HQSAR Analysis of CCR5 Antagonists

(2010) Changdev G. Gadhe et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

(2010) Alexander Pasternak et al.   ACS Medicinal Chemistry Letters

Plerixafor

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Chemokine receptor antagonists: part 2

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chemokine receptor antagonists: Part 1

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Comparative Docking Study of Anibamine as the First Natural Product CCR5 Antagonist in CCR5 Homology Models

(2009) Guo Li et al.   Journal of Chemical Information and Modeling

Elucidation of Binding Sites of Dual Antagonists in the Human Chemokine Receptors CCR2 and CCR5

(2009) S. E. Hall et al.   MOLECULAR PHARMACOLOGY

Maraviroc, a CCR5 Coreceptor Antagonist That Blocks Entry of Human Immunodeficiency Virus Type 1

(2009) Joshua S Hunt et al.   PHARMACOTHERAPY

Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists

(2008) Robert J. Cherney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series

(2008) Wilna J. Moree et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Binding modes of CCR5-targetting HIV entry inhibitors: Partial and full antagonists

(2008) Ting Wang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Expanding GPCR homology model binding sites via a balloon potential: A molecular dynamics refinement approach

(2008) S. Roy Kimura et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Chemokines and Their Receptors: Drug Targets in Immunity and Inflammation

(2007) Antonella Viola et al.   Annual Review of Pharmacology and Toxicology