Review
Chemistry, Multidisciplinary
Xinghang Dai, Long Ren, Mengxi Liu, Hao Cai, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: MDSCs have been explored as an important immunotherapeutic target in cancer immunology, and nanomedicines have shown potential in reversing immunosuppressive tumors into immunoresponsive ones to enhance therapeutic efficacy.
Article
Pharmacology & Pharmacy
Shaohui Tian, Thomas Welte, Junhua Mai, Yongbin Liu, Maricela Ramirez, Haifa Shen
Summary: A new reagent for enhanced tumor-targeted drug delivery has been identified, which has a higher binding affinity to MDSCs in tumor tissue and can effectively penetrate into the tumor tissue by hitchhiking on MDSCs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
T. Beikler, K. Bunte, Y. Chan, B. Weiher, S. Selbach, U. Peters, A. Klocke, R. M. Watt, T. F. Flemmig
Summary: The study evaluated the safety and efficacy of oral microbiota transplant (OMT) for treating periodontitis in dogs. Results showed that OMT may modulate the microbiota composition in dogs with naturally occurring periodontitis and can be applied safely.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Immunology
Zhuang Chen, Rui Yuan, Shengyun Hu, Weitang Yuan, Zhenqiang Sun
Summary: This review provides a comprehensive description of the characteristics, functions, and mechanisms of myeloid-derived suppressor cell exosomes (MDSCs-Exos) in tumor immunity. MDSCs-Exos show similar immunosuppressive, angiogenesis, and metastatic effects as parental MDSCs. Immunotherapy targeting MDSCs-Exos has great potential in both cancer and non-cancerous diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ting Zhao, Sheng Liu, Nasser H. Hanna, Shadia Jalal, Xinchun Ding, Jun Wan, Cong Yan, Hong Du
Summary: Understanding the mechanisms of MDSC biogenesis, particularly the role of LAL, can facilitate the diagnosis and prognosis of cancer, as well as the development of targeted immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Mai Nguyen, Clodia Osipo
Summary: Breast cancer therapies have improved survival rates, but recurrence and drug resistance remain challenging. Phytoestrogens have been found to target breast cancer stem cells and may complement conventional therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yunzhi Dang, Jiao Yu, Shuhong Zhao, Long Jin, Ximing Cao, Qing Wang
Summary: This study reveals a novel role of GOLM1 in promoting CRC metastasis, with its overexpression promoting immune escape and metastasis by recruiting MDSCs. The specific inhibitor of CCR2, PF-04136309, can effectively suppress GOLM1-mediated CRC metastasis, suggesting GOLM1 as a prognostic biomarker in human CRC.
Article
Chemistry, Physical
Tian Zhang, Honggang Xiong, Xianbin Ma, Yuan Gao, Peng Xue, Yuejun Kang, Zhi-Jun Sun, Zhigang Xu
Summary: Utilizing FIT nanoparticles to co-deliver TAD and ICG effectively targets MDSCs and enhances tumor immunogenicity, promoting ICD induction and alleviation of MDSCs for enhancing photothermal immunotherapy. In vivo experiments demonstrate improved immune response and ICB efficacy.
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jiao Yu, Xiaojiao Chen, Shuhong Zhao, Jingchen Jing, Qing Wang, Yunzhi Dang
Summary: This study found that HOXC10 is associated with metastasis in CRC patients and has prognostic value. HOXC10 overexpression enhances the metastatic ability of CRC cells and promotes the infiltration of MDSCs by upregulating CXCL5. CXCR2 inhibitors and anti-PD-L1 can effectively prevent CRC metastasis.
Review
Immunology
Celia Maria Curieses Andres, Jose Manuel Perez de la Lastra, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: Myeloid-derived suppressor cells (MDSCs) are expanded and dysregulated during various pathological processes, including cancer and COVID-19. They have the remarkable ability to suppress T cell and NK cell responses. The presence of reactive oxygen species (ROS) is associated with the presence of MDSCs in both cancer and COVID-19.
Article
Critical Care Medicine
Katherine E. Bline, Jennifer A. Muszynski, Adam J. Guess, Somaang Menocha, Melissa D. Moore-Clingenpeel, Jill K. Popelka, Josey M. Hensley, Lisa M. Steele, Ian C. Goldthwaite, Kathleen J. Jedreski, Mark W. Hall
Summary: This study found that children with septic shock have increased levels of MDSCs and impaired immune function compared to healthy controls. An initial percentage of MDSCs of 25.2% of total PBMCs was optimal in discriminating children with septic shock who experienced prolonged organ dysfunction. Additionally, children with prolonged organ dysfunction exhibited decreased TNF-alpha production capacity over time.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Review
Oncology
Cheng Cui, Penglin Lan, Li Fu
Summary: Gastrointestinal cancer is the most common type of cancer worldwide, with increasing incidence and mortality rates. Myeloid-derived suppressor cells (MDSCs) play a key role in regulating the immune response to tumors and may serve as prognostic markers and therapeutic targets in cancer patients.
CANCER COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Keywan Mortezaee
Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature immune cells that significantly increase in cancer patients, releasing factors that impact tumor-related events such as metastasis and immune evasion, and can serve as an indicator of tumor prognosis. They can be targeted in combination with current immunotherapies to enhance the immune system's response against tumors.
Article
Immunology
Natalie Gibbons, Michelle R. Goulart, Yu-Mei Chang, Konstantinos Efstathiou, Robert Purcell, Ying Wu, Laureen M. Peters, Mark Turmaine, Balazs Szladovits, Oliver A. Garden
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2017)
Article
Oncology
Brian M. Andersen, G. Elizabeth Pluhar, Charles E. Seiler, Michelle R. Goulart, Karen S. SantaCruz, Melissa M. Schutten, Joyce P. Meints, M. Gerard O'Sullivan, R. Timothy Bentley, Rebecca A. Packer, Stephanie A. Thomovsky, Annie V. Chen, Dominik Faissler, Wei Chen, Matthew A. Hunt, Michael R. Olin, John R. Ohlfest
Article
Immunology
G. Elizabeth Pluhar, Patrick T. Grogan, Charlie Seiler, Michelle Goulart, Karen S. SantaCruz, Cathy Carlson, Wei Chen, Mike R. Olin, Pedro R. Lowenstein, Maria G. Castro, Stephen J. Haines, John R. Ohlfest
Article
Multidisciplinary Sciences
Ying Wu, Yu-Mei Chang, Anneliese J. Stell, Simon L. Priestnall, Eshita Sharma, Michelle R. Goulart, John Gribben, Dong Xia, Oliver A. Garden
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Hemant M. Kocher, Bristi Basu, Fieke E. M. Froeling, Debashis Sarker, Sarah Slater, Dominic Carlin, Nandita M. deSouza, Katja N. De Paepe, Michelle R. Goulart, Christine Hughes, Ahmet Imrali, Rhiannon Roberts, Maria Pawula, Richard Houghton, Cheryl Lawrence, Yathushan Yogeswaran, Kelly Mousa, Carike Coetzee, Peter Sasieni, Aaron Prendergast, David J. Propper
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Michelle R. Goulart, Sabina I. Hlavaty, Yu-Mei Chang, Gerry Polton, Anneliese Stell, James Perry, Ying Wu, Eshita Sharma, John Broxholme, Avery C. Lee, Balazs Szladovits, Mark Turmaine, John Gribben, Dong Xia, Oliver A. Garden
SCIENTIFIC REPORTS
(2019)