Article
Cell Biology
Julie Faitg, Clay Lacefield, Tracey Davey, Kathryn White, Ross Laws, Stylianos Kosmidis, Amy K. Reeve, Eric R. Kandel, Amy E. Vincent, Martin Picard
Summary: This study used quantitative three-dimensional electron microscopy to map mitochondrial network morphology and complexity in the mouse brain. Differences in mitochondrial morphology across different cell types and ages were identified, providing a foundation for further research on the role of neuronal mitochondria in the aging brain.
Article
Multidisciplinary Sciences
Shivaprasad H. Sathyanarayana, Jasmine A. Saunders, Jacob Slaughter, Kamran Tariq, Rajarshi Chakrabarti, Madhumala K. Sadanandappa, Bryan W. Luikart, Giovanni Bosco
Summary: This study investigated the interaction between PTEN and FMRP in the development of hippocampal granule neurons. The findings suggest that PTEN protein expression is negatively regulated by FMRP, and disruptions in this regulation may contribute to the pathogenesis of Fmr1-related fragile X neurodevelopmental disorders. The study also showed that heterozygosity of Pten can partially restore cellular phenotypes caused by Fmr1 knockout, while complete deletion of both Pten and Fmr1 results in severe abnormalities in neuron development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sreyashi Samaddar, Sudarshana Purkayastha, Souleymane Diallo, Subramanyam J. Tantry, Ryan Schroder, Pranavan Chanthrakumar, Michael J. Flory, Probal Banerjee
Summary: The neurotransmitter serotonin and its receptor 5-HT1A play a crucial role in mood disorders and brain development. Stimulation of 5-HT1A receptor leads to increased neuroblast proliferation through the PKCε and ERK1/2 signaling pathway, ultimately resulting in the development of mature neurons in the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ana R. A. A. Quadros, Rocio Diez Arazola, Andrea Romaguera Alvarez, Johny Pires, Rhiannon M. Meredith, Ingrid Saarloos, Matthijs Verhage, Ruud F. Toonen
Summary: FBXO41 plays a critical role in synaptic transmission and brain development, and its loss can lead to deficits in these processes.
Article
Neurosciences
Kai-Ge Ma, Hai-Bo Hu, Jin-Song Zhou, Chao Ji, Qi-Sheng Yan, Si-Ming Peng, Lan-Dong Ren, Bing-Nan Yang, Xin-Li Xiao, Yan-Bing Ma, Feng Wu, Kai-Wei Si, Xiao-Lin Wu, Jian-Xin Liu
Summary: It has been found that Gpc4 plays a crucial role in the development of mossy fiber sprouting in the hippocampus, with the mTOR pathway being essential for Gpc4-regulated MFS. Additionally, suppressing Gpc4 expression after status epilepticus has shown to attenuate spontaneous recurrent seizures, indicating that Gpc4 may be a promising target for antiepileptic studies.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
Joanna Mattis, Ala Somarowthu, Kevin M. Goff, Evan Jiang, Jina Yom, Nathaniel Sotuyo, Laura M. Mcgarry, Huijie Feng, Keisuke Kaneko, Ethan M. Goldberg
Summary: Dravet syndrome is a neurodevelopmental disorder characterized by treatment-resistant epilepsy, intellectual disability, and increased risk of sudden death. A study found that there is a dysfunction in the filtering of input signals in the hippocampal dentate gyrus in a mouse model of Dravet syndrome. This dysfunction is not due to impaired inhibitory neurons, but rather excessive excitation to granule cells. Stimulation of certain neurons or inhibiting inhibitory neurons can lower the seizure threshold in these mice. Activation of inhibitory neurons can normalize the neuronal responses.
Article
Nutrition & Dietetics
Xiaoxuan Hu, Jing An, Qian Ge, Meiqi Sun, Zixuan Zhang, Zhenlu Cai, Ruolan Tan, Tianyou Ma, Haixia Lu
Summary: Maternal high-fat diet during pregnancy and lactation impairs neurogenesis in offspring by reducing neural stem cells and promoting premature neuronal differentiation.
Article
Neurosciences
Lyles R. Clark, Sanghee Yun, Nana K. Acquah, Priya L. Kumar, Hannah E. Metheny, Rikley C. C. Paixao, Akivas S. Cohen, Amelia J. Eisch
Summary: This study discusses the impact of mild traumatic brain injuries (mTBIs) on the process of adult hippocampal DG neurogenesis. The results show that mTBI induces transient increases in neurogenesis in the ipsilateral hippocampal region, but not in the contralateral hemisphere. These findings are important for understanding the functional implications of TBI-induced neurogenesis and potential neuron replacement or repair after TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jorg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav Korobeynyk, Izaskun Mallona, Fritjof Helmchen, Francois Guillemot, Benjamin D. Simons, Sebastian Jessberger
Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Zhiting Gong, Zongliang Wang, Le Jiang, Xiaobing Wang, Bensi Zhang, Manoj Kumar Vashisth, Qiang Zhou
Summary: This study demonstrates that inhibiting fear memory renewal by conducting an extinction procedure within the reconsolidation window leads to increased c-fos expression in the dorsal dentate gyrus (dDG). Activating the excitatory neurons in the dDG during extinction training enhances fear memory extinction and prevents renewal, while inhibiting these excitatory neurons hinders fear memory extinction. Additionally, inhibiting fear engram cells during extinction training also inhibits fear memory extinction.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Sarah Houben, Megane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie Ando
Summary: AHN plays a critical role in sustaining hippocampal functions such as learning and memory, and impaired AHN in AD patients may contribute to cognitive deficits. NFTs and amyloid plaques are key neuropathological hallmarks of AD, with abnormal tau protein accumulation impacting AHN. Further research is needed to fully understand the relationship between tau pathology and AHN.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Marc Briquet, Anne-Berengere Rocher, Maxime Alessandri, Nadia Rosenberg, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Celine Schmuziger, Vanessa Ginet, Julien Puyal, Etienne Pralong, Roy Thomas Daniel, Stefan Offermanns, Jean-Yves Chatton
Summary: Lactate can be utilized by neurons as an energy source and can decrease synaptic activity through activation of HCAR1 receptor, making HCAR1 an attractive target for the treatment of epilepsy.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Psychiatry
Hu Meng, Qiongwei Li, Jinxin Wang, Weihua Yue, Dai Zhang, Xiaoxuan Sun, Lifang Wang, Jun Li
Summary: Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social interaction and communication. This study aimed to improve the social deficit in a mouse model by increasing neurogenesis in the hippocampus. Three approaches were used: repeated oxytocin administration, enriched environment, and overexpression of Cdk4-CyclinD1 complex in neural stem cells. Results showed increased proliferation of neural stem cells and newborn neurons, as well as significant improvement in social recognition deficit. These findings provide new insight into the treatment of autism.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Jaclyn Iannucci, Damir Nizamutdinov, Lee A. Shapiro
Summary: Gulf War illness (GWI) is a chronic disorder associated with exposure to neurological chemicals. A mouse model study showed that continuous vagus nerve stimulation can improve some symptoms.
Article
Neurosciences
Shu-Xin Zhang, Li-Hui Duan, Hong Qian, Xiang Yu
NEUROSCIENCE BULLETIN
(2016)
Article
Neurosciences
Min-Yin Li, Wan-Ying Miao, Qiu-Zi Wu, Shun-Ji He, Guoquan Yan, Yanrui Yang, Jia-Jia Liu, M. Mark Taketo, Xiang Yu
Article
Neurosciences
Miao Wang, Huiping Li, Toru Takumi, Zilong Qiu, Xiu Xu, Xiang Yu, Wen-Jie Bian
NEUROSCIENCE BULLETIN
(2017)
Editorial Material
Neurosciences
Xiang Yu, Zilong Qiu, Dai Zhang
NEUROSCIENCE BULLETIN
(2017)
Article
Behavioral Sciences
Chun-Chun Hu, Xiu Xu, Guo-Liang Xiong, Qiong Xu, Bing-Rui Zhou, Chun-Yang Li, Qi Qin, Chun-Xue Liu, Hui-Ping Li, Yun-Jun Sun, Xiang Yu
Article
Neurosciences
Lihui Duan, Xiao-Di Zhang, Wan-Ying Miao, Yun-Jun Sun, Guoliang Xiong, Qiuzi Wu, Guangying Li, Ping Yang, Hang Yu, Humingzhu Li, Yue Wang, Min Zhang, Li-Yuan Hu, Xiaoping Tong, Wen-Hao Zhou, Xiang Yu
Article
Multidisciplinary Sciences
Huimin Liu, Shaoming Sang, Yuan Lu, Zhongfeng Wang, Xiang Yu, Chunjiu Zhong
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Miao Wang, Zixian Yu, Guangying Li, Xiang Yu
Article
Cell Biology
Huateng Cao, Min-Yin Li, Guangying Li, Shu-Jing Li, Bincheng Wen, Yuan Lu, Xiang Yu
Article
Neurosciences
Hang Yu, Wanying Miao, En Ji, Shajin Huang, Sen Jin, Xutao Zhu, Ming-Zhe Liu, Yan-Gang Sun, Fuqiang Xu, Xiang Yu
Summary: Affective and pleasant touch can enhance the firing of oxytocin neurons in mouse paraventricular hypothalamus, promoting social interactions and positive affective valence. Tachykinin 1 neurons in the lateral and ventrolateral periaqueductal gray send excitatory projections to oxytocin neurons in the paraventricular hypothalamus, and their activation promotes social interactions and preference for social touch context.
Editorial Material
Neurosciences
Xiang Yu, Xiu Xu
NEUROSCIENCE BULLETIN
(2023)
Editorial Material
Neurosciences
Xiang Yu
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Neurosciences
Miao Wang, Xiang Yu
Summary: Sensory experience plays a crucial role in shaping the structure and function of neuronal circuits in both development and adulthood. This review examines how experience affects the plasticity of pyramidal neurons in sensory cortices, discussing the advantages and limitations of labeling techniques and identifying the most plastic structural parameters. The review also highlights recent advances in sparse labeling and imaging techniques that could provide insights into unanswered questions in the field of structural plasticity.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Cell Biology
Lingbo Wang, Min-Yin Li, Chao Qu, Wan-Ying Miao, Qi Yin, Jiaoyang Liao, Hua-Teng Cao, Min Huang, Kai Wang, Erwei Zuo, Guangdun Peng, Shu-Xin Zhang, Guodong Chen, Qing Li, Ke Tang, Qian Yu, Zhoujie Li, Catherine C. L. Wong, Guoliang Xu, Naihe Jing, Xiang Yu, Jinsong Li
Article
Cell Biology
Shu-Xin Zhang, Li-Hui Duan, Shun-Ji He, Gui-Feng Zhuang, Xiang Yu