Improved siRNA/shRNA Functionality by Mismatched Duplex

Multilayer checkpoints for microRNA authenticity during RISC assembly

(2011) Tomoko Kawamata et al.   EMBO REPORTS

Silencing Early Viral Replication in Macrophages and Dendritic Cells Effectively Suppresses Flavivirus Encephalitis

(2011) Chunting Ye et al.   PLoS One

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

(2011) S. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

(2010) Dirk Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

(2010) Maria B. Laursen et al.   Molecular BioSystems

Modulation of thermal stability can enhance the potency of siRNA

(2010) H. Addepalli et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

2'-O-Methyl–Modified Anti-MDR1 Fork-siRNA Duplexes Exhibiting High Nuclease Resistance and Prolonged Silencing Activity

(2010) Natalya S. Petrova (Kruglova) et al.   OLIGONUCLEOTIDES

Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

(2010) Olga V. Matveeva et al.   PLoS One

Essential and overlapping functions for mammalian Argonautes in microRNA silencing

(2009) H. Su et al.   GENES & DEVELOPMENT

Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2

(2009) T. Katoh et al.   GENES & DEVELOPMENT

ATP-dependent human RISC assembly pathways

(2009) Mayuko Yoda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

(2009) Tomoko Kawamata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

(2009) Bingbing Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs

(2009) L. L. Snyder et al.   NUCLEIC ACIDS RESEARCH

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Both Strands of siRNA Have Potential to Guide Posttranscriptional Gene Silencing in Mammalian Cells

(2009) Jun-Xia Wei et al.   PLoS One

Alternative Processing of Primary microRNA Transcripts by Drosha Generates 5′ End Variation of Mature microRNA

(2009) Haoquan Wu et al.   PLoS One

Focusing on RISC assembly in mammalian cells

(2008) Junmei Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

(2008) Masayuki Sano et al.   NUCLEIC ACIDS RESEARCH

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Argonaute protein family

(2008) Julia Höck et al.   GENOME BIOLOGY