Article
Entomology
Zhenchen Wu, Jia Ye, Jiali Qian, Endang Rinawati Purba, Qinghe Zhang, Longwa Zhang, Dingze Mang
Summary: Chemosensory receptor genes play an important role in insect chemodetection, but the understanding of these genes in Coleoptera is limited. In this study, the chemosensory receptor genes of the red-necked longicorn beetle were analyzed, and their functions in pheromone sensing and taste perception were identified.
Article
Behavioral Sciences
Daniel Kowatschew, Sigrun Korsching
Summary: The sense of smell relies on large gene families to detect and differentiate various odors. Four major olfactory receptor families have been discovered, with only three already present in lamprey, a jawless vertebrate. However, a fourth family was believed to have originated in jawed vertebrates. This study examined the complete vomeronasal receptor repertoire in three lamprey species and found evidence of v1r and v2r genes, indicating an early origin of the V2R family in the shared ancestor of jawed and jawless vertebrates. Despite the presence of v2r genes, lampreys have not yet acquired an olfactory function for this family, suggesting a disconnect between the evolutionary origin and functional onset of the V2R family as olfactory receptors.
Article
Entomology
Basman H. Al-Jalely, Wei Xu
Summary: The study focused on the olfactory system of Trichogramma pretiosum, identifying 22 putative odorant binding proteins (OBPs) and 105 odorant receptors (ORs) using scanning electron microscopy to observe four types of olfactory sensilla. By examining the expression patterns of OBPs in male and female adults, three female-specific OBPs were identified, suggesting their crucial roles in host-seeking and oviposition behaviors. This research enriches our understanding of T. pretiosum olfactory genes and enhances our knowledge of its olfactory system.
Article
Entomology
Yu Zhang, Kai Feng, Ruolan Mei, Wei Li, Fang Tang
Summary: This study used transcriptome sequencing to investigate the expression of antennal genes in Micromelalopha troglodyta and identified olfactory-related genes. The results showed that these genes are abundantly expressed in the antennae and head, laying the foundation for future research on the olfactory system in M. troglodyta and providing a theoretical basis for biological control.
JOURNAL OF INSECT SCIENCE
(2022)
Article
Parasitology
Zhengbo He, Zhengrong Yu, Xingfei He, Youjin Hao, Liang Qiao, Shihui Luo, Jingjing Zhang, Bin Chen
Summary: This study provides a genome-wide analysis of OR genes in An. sinensis, identifying 59 putative OR genes and investigating their expression patterns and characteristics. The findings suggest the involvement of ORs in odor reception in this species.
PARASITES & VECTORS
(2022)
Review
Physiology
Federica Zinghirino, Xena Giada Pappalardo, Angela Messina, Giuseppe Nicosia, Vito De Pinto, Francesca Guarino
Summary: Despite similarity in sequence and structure, VDAC1 and VDAC2 have different biological roles in normal and pathological conditions. VDAC1 and VDAC2 are expressed at higher levels in human and mouse tissues, except for VDAC3 which is more highly expressed in the reproductive system. The expression of VDAC genes is mainly regulated by transcription factors involved in controlling cell growth, proliferation and differentiation, apoptosis, and bioenergetic metabolism.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Entomology
Jingtao Liu, Jiaoxin Xie, Adel Khashaveh, Jingjiang Zhou, Yongjun Zhang, Hui Dong, Bin Cong, Shaohua Gu
Summary: In this study, odorant receptor genes of the green peach aphid were identified and their phylogenetic relationship and genomic structure were analyzed. The results showed that the odorant receptors of the green peach aphid play an important role in chemical sensing and provide a foundation for investigating the interactions between aphids and hosts and natural enemies.
Article
Multidisciplinary Sciences
Chiori Ijichi, Kenji Kondo, Masayoshi Kobayashi, Ayaka Shirasawa, Kazutaka Shimbo, Kunio Nakata, Yutaka Maruyama, Yusuke Ihara, Yayoi Kawato, Teruhisa Mannen, Rie Takeshita, Yoshimi Kikuchi, Yuki Saito, Tatsuya Yamasoba
Summary: In this study, lipocalin 15 (LCN15) was identified as an abundant component of olfactory mucus. LCN15 localized to the Bowman's glands of the olfactory cleft mucosa and was produced in non-degenerated areas of the olfactory neuroepithelium. The concentration of LCN15 in the mucus was found to be lower in older individuals with normal olfaction and tended to be lower in patients with idiopathic olfactory loss, suggesting that LCN15 may serve as a biomarker for Bowman's gland activity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yaoyao Chen, Boer Hong, Yuhua Zhang, Xiaolian Chen, Tong Zhang, Guohua Zhong, Xin Yi
Summary: Animals under nutrient-poor conditions save energy by adjusting behavior and physiology. Starvation attenuates olfactory responses in Bactrocera dorsalis, which can be reversed by sugar re-feeding but not protein-rich diet. The study reveals the FoxO-Ors axis as a regulatory mechanism for odorant receptors during starvation and re-feeding cycles, providing an improved understanding of how the insulin signaling pathway shapes olfactory plasticity.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Entomology
Basman H. Al-Jalely, Penghao Wang, Yalin Liao, Wei Xu
Summary: This study conducted transcriptome sequencing on the antennae of male and female adult Diadegma semiclausum wasps, revealing differential expression of OBPs and ORs, providing important insights into the olfactory system of D. semiclausum.
BULLETIN OF ENTOMOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Shoko Nakamuta, Masanori Mori, Miho Ito, Masanori Kurita, Masao Miyazaki, Yoshio Yamamoto, Nobuaki Nakamuta
Summary: The olfactory organ of turtles has an upper chamber epithelium (UCE) with associated glands and a lower chamber epithelium (LCE) devoid of glands. The UCE is responsible for detecting airborne odorants, while the LCE detects waterborne odorants. This study investigated the localization of odorant receptors (ORs) in green sea turtle hatchlings, finding that class I ORs were mainly expressed in the LCE, suggesting its sensitivity to waterborne odorants, whereas class II ORs were expressed in both the UCE and LCE, indicating that the entire olfactory organ detects airborne odorants. The widespread expression of class II ORs may enhance sea turtles' ability to sense airborne odorants.
CELL AND TISSUE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Si-Sheng Li, Zhi-Chao Yan, Juan-Juan Zhao, Yuan-Xi Li
Summary: Insects perceive environmental chemicals through olfaction and gustation, leading to behaviors critical for survival. Analysis of chemosensory receptor genes from T. japonicum showed differential expression in male and female heads, with more chemosensory-related genes in females possibly related to host-seeking or mate sensing behaviors. The study identified 66 chemosensory receptor genes, mainly ORs, IRs, and GRs, highly expressed in the heads, suggesting roles in olfaction and gustation, with potential functions in host-seeking or mate sensing.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Review
Pharmacology & Pharmacy
Tao Tong, Yanan Wang, Seong-Gook Kang, Kunlun Huang
Summary: This study outlines the key biological functions and potential molecular mechanisms of ectopic ORs in response to flavor compounds, discussing research opportunities for utilizing them as therapeutic strategies in the treatment of human disease and the challenges to be overcome in the future. The recognition of the potential of ectopic ORs, especially in response to food-derived odorant compounds, as a promising therapeutic strategy for various diseases is emphasized, given their potent function, signaling pathway, and pharmacology in diverse tissues and cell types as G protein-coupled receptors.
Article
Multidisciplinary Sciences
Dania Jundi, Jean-Pierre Coutanceau, Erika Bullier, Soumaiya Imarraine, Ziad Fajloun, Elim Hong
Summary: The expression of olfactory receptor (OR) genes in non-olfactory tissues has been found in rodents and humans, with over 400 genes in humans and 1000 in rodents. Zebrafish have around 140 OR genes, with 31 genes expressed in various tissues, showing conservation of expression in non-olfactory tissues across vertebrates.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxiao Wang, Haoyu Liu, Guanglin Xie, Wenkai Wang, Yuxia Yang
Summary: In this study, transcriptomes from different tissues of the soldier beetle Podabrus annulatus were sequenced and analyzed. A total of 75.74 Gb clean reads were obtained and assembled into 95,274 unigenes. Annotation and tBLASTn results identified 101 candidate olfactory-related genes, including OBPs, CSPs, ORs, GRs, IRs, and SNMPs. Phylogenetic analyses showed a close relationship between Podabrus annulatus and Photinus pyralis in terms of ORs, GRs, and IRs. Differential expression analysis revealed tissue-specific expression patterns of certain OBPs. This study lays the foundation for future research on the molecular mechanism of olfactory recognition in Podabrus annulatus.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Gabriela D. A. Guardia, Bruna R. Correa, Patricia Rosa Araujo, Mei Qiao, Suzanne Burns, Luiz O. F. Penalva, Pedro A. F. Galante
NPJ GENOMIC MEDICINE
(2020)
Article
Neurosciences
Leonardo Fontoura Ormundo, Cleiton Fagundes Machado, Erika Demasceno Sakamoto, Viviane Simoes, Lucia Armelin-Correa
MOLECULAR AND CELLULAR NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Isaias Glezer, Alexandre Bruni-Cardoso, Deborah Schechtman, Bettina Malnic
Summary: Olfactory disorders are increasingly being reported in individuals infected with SARS-CoV-2, impacting quality of life and potentially leading to various health issues. Infected individuals experience sudden loss of smell without the typical nasal congestion seen in common colds or other respiratory infections, suggesting a distinct mechanism for olfactory loss in COVID-19.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Maysa M. Cruz, Jussara J. Simao, Roberta D. C. C. de Sa, Talita S. M. Farias, Viviane S. da Silva, Fernanda Abdala, Vitor J. Antraco, Lucia Armelin-Correa, Maria Isabel C. Alonso-Vale
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Biochemical Research Methods
Natallia Kalinava, Abraham Apfel, Robert Cartmell, Sujaya Srinivasan, Ming-Shan Chien, Kyung In Kim, Ryan Golhar, Kathryn E. Bednarz, Saumya Pant, Joseph Szustakowski, Scott D. Chasalow, Ariella Sasson, Stefan Kirov
Review
Cell Biology
Smija M. Kurian, Rafaella G. Naressi, Diogo Manoel, Ann-Sophie Barwich, Bettina Malnic, Luis R. Saraiva
Summary: Odor detection starts with the activation of odorant receptors in mature olfactory sensory neurons, and different odorants activate unique receptors, providing an explanation for perceiving different odors. Recent studies have found that antagonist interactions play an important role in the formation of combinatorial receptor code.
CELL AND TISSUE RESEARCH
(2021)
Article
Neurosciences
Artur Guazzelli Leme Silva, Maira Harume Nagai, Thiago Seike Nakahara, Bettina Malnic
Summary: Analysis of the Olfr17 gene expression in mice revealed differential levels between genetic backgrounds, indicating a significant impact of genetic variations and epigenetic modifications on OR gene alleles.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Article
Nutrition & Dietetics
Vitor Jaco Antraco, Bruna Kelly Sousa Hirata, Jussara de Jesus Simao, Maysa Mariana Cruz, Viviane Simoes da Silva, Roberta Dourado Cavalcante da Cunha de Sa, Fernanda Miranda Abdala, Lucia Armelin-Correa, Maria Isabel Cardoso Alonso-Vale
Summary: The study showed that n-3 PUFA can alleviate obesity, dyslipidemia, and hepatic steatosis induced by HFD. FO treatment decreased excessive accumulation and hypertrophy of white adipose tissue, while increasing adipocyte numbers, contributing to the healthy expansion of WAT.
Article
Physiology
Mariana Ferreira Sbrana, Marco Aurelio Fornazieri, Alexandre Bruni-Cardoso, Vivian Avelino-Silva, Deborah Schechtman, Richard Louis Voegels, Bettina Malnic, Isaias Glezer, Fabio de Rezende Pinna
Summary: During the COVID-19 pandemic, a higher incidence of olfactory dysfunction was observed in healthcare professionals who tested positive for SARS-CoV-2, with high rates of remission within two weeks.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Viviane S. da Silva, Jussara J. Simao, Victor Plata, Andressa Franca de Sousa, Roberta D. C. da Cunha de Sa, Cleiton Fagundes Machado, Taiza Stumpp, Maria Isabel C. Alonso-Vale, Lucia Armelin-Correa
Summary: This study analyzed the effects of a high-fat diet on the posttranscriptional modifications of H3K27 and the expression of histone-modifying enzymes in adipose-derived stromal cells (ASCs) from white adipose tissue. The results showed that an HFD significantly reduces the acetylation of H3K27 in ASCs and the expression of ATP-citrate lyase in subcutaneous ASCs.
Editorial Material
Pharmacology & Pharmacy
Rafaella G. Naressi, Deborah Schechtman, Bettina Malnic
Summary: Odorant receptors (ORs) are G protein-coupled receptors highly expressed in olfactory sensory neurons. Recent evidence suggests they are also expressed in nonolfactory tissues, making them potential drug targets. This article discusses the challenges and strategies in targeting these receptors.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Jussara J. Simao, Maysa M. Cruz, Fernanda M. Abdala, Andressa Bolsoni-Lopes, Lucia Armelin-Correa, Maria Isabel C. Alonso-Vale
Summary: The study demonstrates that palmitoleic acid (n7) can alleviate or prevent low-grade chronic inflammation caused by obesity by inducing adipocyte differentiation and reducing the expression of inflammatory cytokines.
Article
Genetics & Heredity
Adriana Di-Battista, Bianca Pereira Favilla, Malu Zamariolli, Natalia Nunes, Alexandre Defelicibus, Lucia Armelin-Correa, Israel Tojal da Silva, Alexandre Reymond, Mariana Moyses-Oliveira, Maria Isabel Melaragno
Summary: The repositioning effect of balanced X-autosome translocations may be a key mechanism underlying the pathogenesis of premature ovarian insufficiency (POI).
EPIGENETICS & CHROMATIN
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Phelipe Silva, Cassandra Lyra, Bettina Malnic, Ana Takakura, Thiago Moreira