The Atypical Stimulant and Nootropic Modafinil Interacts with the Dopamine Transporter in a Different Manner than Classical Cocaine-Like Inhibitors

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue

(2011) Yongfang Zhao et al.   NATURE

Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113

(2011) Erik R. Hill et al.   NEUROPHARMACOLOGY

The Substrate-Driven Transition to an Inward-Facing Conformation in the Functional Mechanism of the Dopamine Transporter

(2011) Jufang Shan et al.   PLoS One

Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies

(2010) David V. Herin et al.   Annals of the New York Academy of Sciences

The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization

(2010) Angela M. Batman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys.

(2010) Jennifer L. Newman et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Effect of an acute d-amphetamine administration on context information memory in healthy volunteers: evidence from a source memory task

(2010) Inge Zeeuws et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding

(2010) Weimin C. Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant

(2010) Tai-Xiang Xu et al.   JOURNAL OF NEUROCHEMISTRY

Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter

(2010) Kyle C. Schmitt et al.   JOURNAL OF NEUROCHEMISTRY

N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects

(2010) S.-M. Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dopamine Transporter-Dependent and -Independent Striatal Binding of the Benztropine Analog JHW 007, a Cocaine Antagonist with Low Abuse Liability

(2010) T. A. Kopajtic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

(2010) Yongfang Zhao et al.   NATURE

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site

(2010) Chayne L. Piscitelli et al.   NATURE

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters

(2010) Derek P Claxton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus

(2010) Marian Tsanov et al.   NEUROPHARMACOLOGY

Modulatory Effects of Modafinil on Neural Circuits Regulating Emotion and Cognition

(2010) Roberta Rasetti et al.   NEUROPSYCHOPHARMACOLOGY

Modafinil Blocks Reinstatement of Extinguished Opiate-Seeking in Rats: Mediation by a Glutamate Mechanism

(2010) Pouya Tahsili-Fahadan et al.   NEUROPSYCHOPHARMACOLOGY

Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates

(2010) Paul W. Czoty et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents

(2010) Neil E. Paterson et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

SARs at the Monoamine Transporters for a Novel Series of Modafinil Analogues

(2010) Jianjing Cao et al.   ACS Medicinal Chemistry Letters

Modafinil does not serve as a reinforcer in cocaine abusers

(2009) Suzanne K. Vosburg et al.   DRUG AND ALCOHOL DEPENDENCE

Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain

(2009) Nora D. Volkow et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters

(2009) Ying-Jian Liang et al.   JOURNAL OF NEUROCHEMISTRY

Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil

(2009) D. Zolkowska et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity

(2009) G. Tanda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors

(2009) T. Hiranita et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanism for Cocaine Blocking the Transport of Dopamine: Insights from Molecular Modeling and Dynamics Simulations

(2009) Xiaoqin Huang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures

(2009) Zheng Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Dopamine Uptake Inhibitor 3α-[bis(4′-fluorophenyl)metoxy]-tropane Reduces Cocaine-Induced Early-Gene Expression, Locomotor Activity and Conditioned Reward

(2009) Clara Velázquez-Sánchez et al.   NEUROPSYCHOPHARMACOLOGY

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

(2009) M. Quick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics of leucine and dopamine transporter proteins in a model cell membrane lipid bilayer

(2009) Patrick C. Gedeon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Depression-like deficits in rats improved by subchronic modafinil

(2009) Ralf Regenthal et al.   PSYCHOPHARMACOLOGY

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter

(2008) Julie Kniazeff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area

(2008) Paul Labute   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site

(2008) Lei Shi et al.   MOLECULAR CELL

The binding sites for cocaine and dopamine in the dopamine transporter overlap

(2008) Thijs Beuming et al.   NATURE NEUROSCIENCE

Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys

(2008) Heather L. Kimmel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Modafinil improves rapid shifts of attention

(2008) Natalie L. Marchant et al.   PSYCHOPHARMACOLOGY

A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation

(2008) S. K. Singh et al.   SCIENCE

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

(2007) Richard B. Rothman et al.   BIOCHEMICAL PHARMACOLOGY

The explicit learning of new names for known objects is improved by dexamphetamine

(2007) Emma Whiting et al.   BRAIN AND LANGUAGE