Article
Multidisciplinary Sciences
Denise Chan, Phillip R. Bennett, Yun S. Lee, Samit Kundu, T. G. Teoh, Malko Adan, Saqa Ahmed, Richard G. Brown, Anna L. David, Holly Lewis, Belen Gimeno-Molina, Jane E. Norman, Sarah J. Stock, Vasso Terzidou, Pascale Kropf, Marina Botto, David A. MacIntyre, Lynne Sykes
Summary: This study provides mechanistic insight into the role of vaginal microbiota and immunological factors in spontaneous preterm birth (sPTB). The findings suggest that the complement system, in conjunction with specific vaginal microbial and associated immunological changes, contributes to the development of sPTB.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Nataschja I. Ho, Marcel G. Camps, Juan J. Garcia-Vallejo, Erik Bos, Abraham J. Koster, Martijn Verdoes, Yvette van Kooyk, Ferry Ossendorp
Summary: Dendritic cells have the unique ability to present exogenous antigens through MHC class I molecules, with the antigen being conserved in storage compartments for days. These compartments in DCs lack certain molecules involved in MHC class I processing, and the co-localization of active cathepsin X with protein antigen suggests a novel role for cathepsin X in antigen processing and cross-presentation. These compartments can preserve protein antigens from different uptake routes and contribute to long-lasting antigen cross-presentation.
Article
Chemistry, Multidisciplinary
Philipp Schineis, Zuzanna K. Kotkowska, Sarah Vogel-Kindgen, Mona C. Friess, Martine Theisen, David Schwyter, Lucy Hausammann, Saurav Subedi, Eleni M. Varypataki, Ying Waeckerle-Men, Isabel Kolm, Thomas M. Kuendig, Anders Hogset, Bruno Gander, Cornelia Halin, Pal Johansen
Summary: Antigen cross-presentation to cytotoxic CD8+ T cells is crucial for anti-tumor and anti-viral immune responses. Co-encapsulation of photosensitizers and antigens into microspheres with subsequent photochemical internalization has emerged as a promising strategy. In vivo, dendritic cells take up the microspheres in peripheral tissues and migrate to tissue-draining lymph nodes for CD8+ T cell priming.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Susmita K. Singh, Marie Larsson, Thomas Schon, Olle Stendahl, Robert Blomgran
JOURNAL OF IMMUNOLOGY
(2019)
Article
Allergy
Jonas Hultberg, Jan Ernerudh, Marie Larsson, Asa Nilsdotter-Augustinsson, Sofia Nystrom
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Review
Microbiology
Yean K. Yong, Hong Y. Tan, Alireza Saeidi, Won F. Wong, Ramachandran Vignesh, Vijayakumar Velu, Rajaraman Eri, Marie Larsson, Esaki M. Shankar
FRONTIERS IN MICROBIOLOGY
(2019)
Editorial Material
Immunology
A. S. Smiline Girija, Esaki M. Shankar, Marie Larsson
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Esaki M. Shankar, Karlhans F. Che, Yean K. Yong, A. S. Smiline Girija, Vijayakumar Velu, Abdul W. Ansari, Marie Larsson
Summary: A significant number of COVID-19 patients are asymptomatic carriers, contributing to the exponential increase in global cases, while some regions boast a surprisingly high recovery rate. Understanding how exotic animals control viruses and regulate inflammation could provide valuable insights for developing therapeutic strategies against COVID-19.
PATHOGENS AND DISEASE
(2021)
Article
Medicine, Research & Experimental
Sui-Weng Wong, Yi-Wen Ting, Yean-Kong Yong, Hong-Yien Tan, Muttiah Barathan, Behnaz Riazalhosseini, Chook Jack Bee, Kok-Keng Tee, Marie Larsson, Vijayakumar Velu, Esaki M. Shankar, Rosmawati Mohamed
Summary: This study investigates the pathogenesis of NAFLD in patients with chronic HBV infection and reveals the correlation between liver function markers and NAFLD as well as liver fibrosis. IL-13 and CCL11 play crucial roles in linking metabolic syndrome, chronic inflammation, and progression of liver cirrhosis in CHB patients.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2021)
Article
Immunology
Cecilia Svanberg, Rada Ellegard, Elisa Crisci, Mohammad Khalid, Ninnie Borendal Wodlin, Maria Svenvik, Sofia Nystrom, Kenzie Birse, Adam Burgener, Esaki M. Shankar, Marie Larsson
Summary: Exposure of cervical biopsies to complement-opsonized HIV increased the rate of infection, with enhanced expression of genes and proteins associated with viral replication. The findings suggest that HIV opsonization alters signaling pathways in cervical mucosa to promote viral establishment and infection, laying a foundation for further studies on early HIV-induced events in pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Johanna Raffetseder, Robert Lindau, Sigrid van der Veen, Goran Berg, Marie Larsson, Jan Ernerudh
Summary: During pregnancy, MAIT cells play dual roles in immune modulation and antimicrobial defense, requiring strict regulation to prevent pregnancy complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Helena Enocsson, Jonas Wettero, Maija-Leena Eloranta, Birgitta Gullstrand, Cecilia Svanberg, Marie Larsson, Anders A. Bengtsson, Lars Ronnblom, Christopher Sjowall
Summary: This study evaluated the potential of galectin-9 and a range of chemokines/cytokines as surrogate markers of type I IFN and/or SLE disease activity. The results demonstrated an association between galectin-9 and CXCL10 with type I IFN in SLE but a stronger correlation with TNF. Despite CXCL10 and CCL19 performing best in terms of disease activity association, none of the investigated biomarkers showed a convincing relationship with disease activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anirban Sengupta, Mohammad Azharuddin, Maria E. Cardona, Claudia Devito, Eleanore von Castelmur, Anna Wehlin, Zuzanna Pietras, Maria Sunnerhagen, Robert Selegard, Daniel Aili, Ali Alamer, Jorma Hinkula, Noha Al-Otaibi
Summary: This study investigated the effectiveness of using a combination of specific antigens and adjuvants through intranasal administration in inducing immune responses. The results showed that this strategy was able to induce both mucosal and systemic immune responses. Additionally, lipid adjuvants were found to enhance the vaccine effect.
Review
Immunology
Anirban Sengupta, Mohammad Azharuddin, Noha Al-Otaibi, Jorma Hinkula
Summary: The use of gold nanoparticles (GNPs) in vaccine development has gained popularity due to their excellent properties in biocompatibility, immune modulation, and antigen delivery. GNPs can effectively combat various pathogens by modulating immune responses of cells and antibodies. Despite their potential toxicity, it is worth further exploring and investing in GNPs for vaccine development.
Article
Immunology
Armin Spreco, Orjan Dahlstrom, Anna Joud, Dennis Nordvall, Cecilia Fagerstrom, Eva Blomqvist, Fredrik Gustafsson, Jorma Hinkula, Thomas Schon, Toomas Timpka
Summary: Hybrid immunity provides greater protection against breakthrough infection compared to vaccination alone, but the benefits are diminished for high-risk populations and with the circulation of the Omicron variant and its sublineages.
Article
Biochemistry & Molecular Biology
Maria E. Cardona, Jorma Hinkula, Kristin Gustafsson, Birger Christensson, Britta Wahren, Abdalla J. Mohamed, C. I. Edvard Smith, H. Jose Arteaga
Summary: Treatment with RNAi against HIV-1 transcripts can effectively inhibit viral replication but also leads to the selection of escape mutants. Blocking both viral and host transcripts improves the antiviral effect. The study demonstrates that short hairpin RNA (shRNA) targeting CCR5 provides more sustained protection than shRNA targeting HIV-1 rev. Partial reduction in CCR5 expression significantly decreases HIV-1 infection, and shCCR5 performs better than shRev in mixed treated and untreated cultures.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Jasmin Knopf, Johanna Sjowall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjowall
Summary: The severity of COVID-19 is related to immune response, which raises concerns for patients with autoimmune disorders. Thromboembolism, characterized by the occlusion of vessels by NETs, is a complication of COVID-19. This study suggests that an imbalance in NET formation and clearance may exacerbate autoimmunity and disease severity. Serologic evidence of SARS-CoV-2 exposure has minor impact on the course of SLE.
Article
Immunology
Anirban Sengupta, Noha Al-Otaibi, Jorma Hinkula, Jixin Zhong
Summary: This study reveals the critical immune mechanisms and sex-specific immune response differences in diabetic individuals after receiving seasonal influenza vaccination. Diabetic females show a shift in immune response towards stronger Th1/Th17 responses but suppressed humoral immunity. Diabetic males exhibit enhanced humoral Th2-immunity. Males recover better and show less weight change. The study suggests a need for sex-specific customized vaccine regimens to take advantage of the strengths and weaknesses in immune protection for individuals with diabetes.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)