Article
Chemistry, Multidisciplinary
Klare L. Bersch, Kristen E. DeMeester, Rachid Zagani, Shuyuan Chen, Kimberly A. Wodzanowski, Shuzhen Liu, Siavash Mashayekh, Hans-Christian Reinecker, Catherine L. Grimes
Summary: The article discusses the impact of bacterial peptidoglycan (PG) recognition elements on the human innate immune system, as well as immunostimulatory studies using synthesized PG-based disaccharide ligands.
ACS CENTRAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Ibrahim M. Sayed, Stella-Rita Ibeawuchi, Dominique Lie, Mahitha Shree Anandachar, Rama Pranadinata, Manuela Raffatellu, Soumita Das
Summary: The host engulfment protein ELMO1 interacts with WxxxE effectors like SifA, influencing intestinal inflammation and bacterial pathogenicity. The ELMO1-WxxxE effector interaction plays a crucial role in regulating bacterial colonization, dissemination, and induction of inflammatory cytokines. It has been found that the interaction between ELMO1 and WxxxE motif-containing effectors, such as SifA, not only affects the pathogenicity of enteric pathogens but also plays a role in modulating inflammatory responses and cellular activities.
Article
Microbiology
Bao-Rui Zhao, Xin-Xin Wang, Xian-Wei Wang
Summary: This study found that MjShoc2 in kuruma shrimp interacts with Vibrio anguillarum flagellin A (FlaA) and mediates its induced expression. The study established the Flagellin/MjShoc2/Erk/Stat signaling axis and revealed a new antibacterial strategy in shrimp.
Article
Engineering, Biomedical
Bon Il Koo, Seon-Mi Jin, Hayeon Kim, Dong Jae Lee, Eunji Lee, Yoon Sung Nam
Summary: The study introduced robust conjugation-free multilamellar protein antigen-lipid hybrid nanovesicles (MPLVs) for efficient antigen-specific immune responses, increasing immunological surface markers and cytokines in dendritic cells. Vaccination with MPLVs significantly enhanced anti-antigen antibody and interferon-gamma production by activating CD4(+) and CD8(+) T cells, suggesting MPLVs as a promising nanovaccine delivery platform for efficient antigen cross-presentation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Guangxia Yang, Kai Wang, Hua Song, Rujie Zhu, Shuai Ding, Hui Yang, Jian Sun, Xin Wen, Lingyun Sun
Summary: This study investigated the effect of celastrol on osteoarthritis (OA) and identified the mechanisms involved. The results showed that celastrol delayed cartilage damage, reduced osteophyte formation and bone resorption in an OA rat model. In vitro experiments also demonstrated that celastrol suppressed the production of inflammatory factors and inhibited matrix degradation. Furthermore, celastrol inhibited the TLR2/NF-kappa B signaling pathway. These findings suggest that celastrol could be a potential therapy for OA by targeting this signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Monika Hollenhorst, Rajender Nandigama, Saskia B. Evers, Igor Gamayun, Noran Abdel Wadood, Alaa Salah, Mario Pieper, Amanda Wyatt, Alexey Stukalov, Anna Gebhardt, Wiebke Nadolni, Wera Burow, Christian Herr, Christoph Beisswenger, Soumya Kusumakshi, Fabien Ectors, Tatjana Kichko, Lisa Huebner, Peter Reeh, Antje Munder, Sandra-Maria Wienhold, Martin Witzenrath, Robert Bals, Veit Flockerzi, Thomas Gudermann, Markus Bischoff, Peter Lipp, Susanna Zierler, Vladimir Chubanov, Andreas Pichlmair, Peter Koenig, Ulrich Boehm, Gabriela Krasteva-Christ
Summary: This study reveals that tracheal brush cells express functional taste receptors and that bitter taste signaling induces neurogenic inflammation, which mediates secretion of immune mediators and defense against bacterial infections.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Microbiology
Beth Mann, Jeremy Chase Crawford, Kavya Reddy, Josi Lott, Yong Ha Youn, Geli Gao, Cliff Guy, Ching-Heng Chou, Daniel Darnell, Sanchit Trivedi, Perrine Bomme, Allister J. J. Loughran, Paul G. G. Thomas, Young-Goo Han, Elaine I. I. Tuomanen
Summary: Maternal antibiotic treatment generates bacterial cell wall (BCW) which interacts with neural progenitor cells (NPCs) in the fetal brain, enhancing their proliferation and inhibiting ciliogenesis. This interaction changes brain structure and function, and is crucial for understanding brain developmental disorders.
Review
Immunology
Ioannis Kienes, Ella L. Johnston, Natalie J. Bitto, Maria Kaparakis-Liaskos, Thomas A. Kufer
Summary: This article summarizes the subversion strategies used by bacterial pathogens to evade host immune detection, focusing on the well-studied NLRs NOD1/2, NLRP3, and NLRC4. The authors discuss how bacterial pathogens activate these NLRs to promote inflammation and disease, as well as mechanisms used by bacteria to attenuate NLR activation and interfere with host immunity. They also highlight the role of NLRs in facilitating immunotolerance and persistence of bacteria in the host, and the therapeutic potential of harnessing bacterial immune subversion strategies for chronic inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tyler G. Normile, Timothy H. Chu, Brian S. Sheridan, Maurizio Del Poeta
Summary: The administration of the Cryptococcus neoformans Delta sgl1 mutant vaccine can protect mice from subsequent infection, even during CD4(+) T cell deficiency. IFN-gamma and IL-17A, produced by gamma delta T cells, play a crucial role in this protection mechanism. The interaction between sterylglucosides (SGs), GXM, and toll-like receptor 2 (TLR2) stimulates the production of IFN-gamma and IL-17A.
MUCOSAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zongjuan Li, Yang Zhang, Weifeng Hong, Biao Wang, Yixing Chen, Ping Yang, Jian Zhou, Jia Fan, Zhaochong Zeng, Shisuo Du
Summary: This study investigates the role of the gut microbiome in regulating response to radiotherapy in hepatocellular carcinoma (HCC) patients. The study found that dysbiosis of the gut microbiome impairs the antitumor immune response and leads to variations in the effectiveness of radiotherapy. The cGAS-STING-IFN-I pathway was identified as a key mechanism in this process. The study proposes cyclic-di-AMP as a potential target for modulating response to radiotherapy in HCC patients.
Article
Multidisciplinary Sciences
Kazuki Nagashima, Aishan Zhao, Katayoon Atabakhsh, Minwoo Bae, Jamie E. Blum, Allison Weakley, Sunit Jain, Xiandong Meng, Alice G. Cheng, Min Wang, Steven Higginbottom, Alex Dimas, Pallavi Murugkar, Elizabeth S. Sattely, James J. Moon, Emily P. Balskus, Michael A. Fischbach
Summary: Certain bacterial strains from the microbiome induce a potent T cell response, and many T cells in the gut repertoire recognize multiple bacterial strains. 13 T cell clones show a one-to-many TCR-to-strain relationship, recognizing 18 Firmicutes strains.
Article
Entomology
Miltan Chandra Roy, Yonggyun Kim
Summary: This study explored cellular immune responses of the mealworm Tenebrio molitor, showing that calcium signaling is associated with eicosanoid mediation, triggering the immune responses in the insect hemocytes.
ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA
(2021)
Article
Biochemistry & Molecular Biology
Sunhyo Ryu, Kareemah Ni, Chenghao Wang, Ayyanar Sivanantham, Jonathan M. Carnino, Hong-Long Ji, Yang Jin
Summary: Emerging evidence suggests that bacterial outer membrane vesicles (OMVs) released by Gram-negative bacteria play an important role in inflammatory responses and organ damage caused by bacterial infections. This study reveals that OMVs from various Gram-negative bacteria can induce pro-inflammatory activation in macrophages and inflammatory lung responses. The effects of OMVs on activating macrophages are more robust than those of LPS, and they trigger both surface protein-mediated signaling and intracellular signaling pathways. Bacterial OMVs should be considered as a repertoire of pathogen-associated molecular patterns (PAMPs) with broader functionality.
Review
Biochemistry & Molecular Biology
Dinshaw J. Patel, You Yu, Ning Jia
Summary: Second-messenger-mediated signaling by cyclic oligonucleotides plays a significant role in immune-mediated antiviral defense. Bacteria and archaea have evolved various complexes to activate effectors for viral defense. The defense mechanism includes the abortive infection mechanism and the suppression of host immunity by phages.
Article
Pharmacology & Pharmacy
Chen Zhang, Zhao Zhao, Peng-Qi Zhang, Sheng Guo, Bin Zhu
Summary: This study demonstrates the immunoprotection of mucosal vaccine G131c and reveals its ability to activate APCs at mucosal sites by interacting with TLR2, resulting in local and systemic immune responses.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Mary C. Gallo, Charmaine Kirkham, Samantha Eng, Remon S. Bebawee, Yong Kong, Melinda M. Pettigrew, Herve Tettelin, Timothy F. Murphy
INFECTION AND IMMUNITY
(2018)
Article
Multidisciplinary Sciences
Melinda M. Pettigrew, Christian P. Ahearn, Janneane F. Gent, Yong Kong, Mary C. Gallo, James B. Munro, Adonis D'Mello, Sanjay Sethi, Herve Tettelin, Timothy F. Murphy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Microbiology
David M. Jacobs, Heather M. Ochs-Balcom, Jiwei Zhao, Timothy F. Murphy, Sanjay Sethi
JOURNAL OF CLINICAL MICROBIOLOGY
(2018)
Article
Infectious Diseases
Fredrik Resman, Guillaume Manat, Victor Lindh, Timothy F. Murphy, Kristian Riesbeck
BMC INFECTIOUS DISEASES
(2018)
Article
Immunology
Timothy F. Murphy, Aimee L. Brauer, Melinda M. Pettigrew, Eric R. LaFontaine, Herve Tettelin
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Immunology
Yu-Ching Su, Emma Mattsson, Birendra Singh, Farshid Jalalvand, Timothy F. Murphy, Kristian Riesbeck
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Chemistry, Medicinal
Livia Shehaj, Santosh K. Choudary, Kamlesh M. Makwana, Mary C. Gallo, Timothy F. Murphy, Joshua A. Kritzer
ACS INFECTIOUS DISEASES
(2019)
Article
Microbiology
Timothy F. Murphy, Charmaine Kirkham, Adonis D'Mello, Sanjay Sethi, Melinda M. Pettigrew, Herve Tettelin
Summary: Chronic obstructive pulmonary disease (COPD) is a common and debilitating disorder that is the third leading cause of death worldwide. This study analyzed the persistence of nontypeable Haemophilus influenzae (NTHi) in COPD airways and found that the NTHi genome undergoes inversion during persistence, resulting in changes in expression of key virulence factors. It was also discovered that the adhesins HMW1 and HMW2 play a critical role in NTHi adherence and invasion of respiratory epithelial cells. These findings provide important insights into the mechanisms of NTHi persistence in COPD airways and may inform the development of novel interventions.
Article
Medicine, Research & Experimental
E. Bengert, L. Towle-Miller, J. Boccardo, G. Mercene, P. J. Ohtake, P. Balkundi, P. L. Elkin, J. Balthasar, T. F. Murphy, K. Noyes
Summary: This study proposes a practical method to track institutional changes in research teamwork and productivity using commonly available electronic databases. The study shows that the extent of interdisciplinary collaboration varies significantly depending on academic unit, faculty appointment, and seniority. Interdisciplinary grants constitute a significant proportion of all grants and have been on the rise in recent years. Departments with more interdisciplinary grants receive more research funding. Further research is needed to improve the efficiency of interdisciplinary collaborations.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Timothy F. Murphy, Rita Hubbard Robinson, Kelly M. Wofford, Alan J. Lesse, Susan Grinslade, Henry L. Taylor, Kinzer M. Pointer, George F. Nicholas, Heather Orom
Summary: The African American population in Buffalo, New York faces significant health disparities due to social determinants of health. A community-university partnership organized the annual Igniting Hope conference series to address these disparities. The series has become the premier conference on health disparities in the region, attracting community members, leaders, university faculty, and trainees. It has led to initiatives such as a new state law, mitigation of COVID-19 fatalities, and the establishment of a university-supported institute.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Microbiology
John M. Atack, Timothy F. Murphy, Melinda M. Pettigrew, Kate L. Seib, Michael P. Jennings
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Immunology
Antonia C. Perez, Antoinette Johnson, Ziqiang Chen, Gregory E. Wilding, Michael G. Malkowski, Timothy F. Murphy
INFECTION AND IMMUNITY
(2018)
Article
Microbiology
Brian T. Tsuji, James Fisher, Raheal Boadi-Yeboah, Patricia N. Holden, Sanjay Sethi, Melinda M. Pettigrew, Timothy F. Murphy
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Respiratory System
David M. Jacobs, Katia Noyes, Jiwei Zhao, Walter Gibson, Timothy F. Murphy, Sanjay Sethi, Heather M. Ochs-Balcom
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2018)
Article
Microbiology
John M. Atack, Timothy F. Murphy, Lauren O. Bakaletz, Kate L. Seib, Michael P. Jennings
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)