Article
Endocrinology & Metabolism
Jesus M. Pradillo, Macarena Hernandez-Jimenez, Maria E. Fernandez-Valle, Violeta Medina, Juan E. Ortuno, Stuart M. Allan, Spencer D. Proctor, Juan M. Garcia-Segura, Maria J. Ledesma-Carbayo, Andres Santos, Maria A. Moro, Ignacio Lizasoain
Summary: The study found that stroke outcomes and angiogenesis/vasculogenesis in old rats are negatively affected by the co-morbidities present in the corpulent genotype. DCE-MRI may be a useful technique for non-invasive evaluation of vascular function and angiogenesis processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Inna Gertsenshteyn, Boris Epel, Amandeep Ahluwalia, Heejong Kim, Xiaobing Fan, Eugene Barth, Marta Zamora, Erica Markiewicz, Hsiu-Ming Tsai, Subramanian Sundramoorthy, Lara Leoni, John Lukens, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Mihai Giurcanu, Brian B. Roman, Gregory Karczmar, Chien-Min Kao, Howard Halpern, Chin-Tu Chen
Summary: This study compared FMISO PET images with pO(2) EPRI in mouse models to identify the optimal FMISO threshold for locating tumor hypoxia, showing a high overall hypoxia similarity between the two imaging methods. Additionally, the correlations between PET/EPRI hypoxia images and vascular permeability and extracellular-extravascular space from DCE-MRI were evaluated.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Nabil F. Saba, Pooja Vijayvargiya, Jan B. Vermorken, Juan P. Rodrigo, Stefan M. Willems, Nina Zidar, Remco de Bree, Antti Maekitie, Greg T. Wolf, Athanassios Argiris, Yong Teng, Alfio Ferlito
Summary: Therapies for squamous cell carcinomas of the head and neck are evolving rapidly, with the inclusion of immunotherapy and anti-angiogenic therapies. This review article explores the utility of anti-VEGF therapies on SCCHN and its interaction with the immune environment. The correlation between VEGF and the progression of SCCHN is strong, with nearly 90% of these cancers expressing VEGF.
Article
Biology
Jintao Ru, Beichen Lu, Buran Chen, Jialin Shi, Gaoxiang Chen, Meihao Wang, Zhifang Pan, Yezhi Lin, Zhihong Gao, Jiejie Zhou, Xiaoming Liu, Chen Zhang
Summary: Breast cancer is the most common cancer in women. Ultrasound and DCE-MRI are widely used for diagnosis, and we propose a segmentation network named Att-U-Node to address the challenges of current deep neural networks. The experiments show that the proposed model achieves competitive results for tumor segmentation and mitigates the common problems of deep neural networks.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Jennifer Hazel Elizabeth Baker, Firas Moosvi, Alastair Hugh Kyle, Judit Puspoky Banath, Katayoun Saatchi, Urs Otto Haefeli, Stefan Alexander Reinsberg, Andrew Ivor Minchinton
Summary: There is a need for a widely available, translatable, sensitive and non-invasive imaging biomarker for tumor hypoxia in radiation oncology. This study investigates the utility of dOE-MRI, a previously validated imaging approach, to detect VEGF-ablation treatment-induced changes in tumor oxygenation that result in radiosensitization. The results illustrate the effectiveness of dOE-MRI as a non-invasive biomarker for treatment response and tumor sensitivity during cancer interventions.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Adrian Moure, Guillermo Vilanova, Hector Gomez
Summary: This study investigates the complex interactions between interstitial flow and the affinity for matrix binding of different chemokine isoforms using a computational model. The results demonstrate that changing the matrix affinity of the chemokine isoform can invert the effect of interstitial flow on angiogenesis. These findings provide insight into the intricate mechanisms of angiogenesis in the tumor microenvironment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Zhiheng Li, Zhenhua Zhao, Chuchu Wang, Dandan Wang, Haijia Mao, Fang Liu, Ye Yang, Feng Tao, Zengxin Lu
Summary: This study aimed to investigate the correlations between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion histogram parameters and vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) expressions in advanced gastric cancer (AGC). The results showed that DCE-MRI perfusion histogram parameters could serve as imaging biomarkers to reflect VEGF and EGFR expressions in different Lauren classifications of AGC and estimate their difference.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
H. Tibermacine, P. Rouanet, M. Sbarra, R. Forghani, C. Reinhold, S. Nougaret
Summary: The study evaluated and compared different radiomics approaches for predicting disease-free survival in patients with locally advanced rectal cancer. The 3D radiomics model outperformed qualitative analysis and showed good performance in predicting DFS. Radiomics models have the potential to predict DFS more accurately than qualitative analysis.
BRITISH JOURNAL OF SURGERY
(2021)
Review
Oncology
Shaotao Jiang, Rongdang Fu, Jiewei Shi, Huijie Wu, Jialuo Mai, Xuefeng Hua, Huan Chen, Jie Liu, Minqiang Lu, Ning Li
Summary: CircRNAs play a crucial role in tumor angiogenesis and hold great potential for diagnosis and treatment of tumors, although the detailed biological regulatory mechanisms require further exploration.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Krishnasamy naidu gopal Hariprabu, Muthusamy Sathya, Selvaraj Vimalraj
Summary: Tumor angiogenesis is a critical target for cancer treatment, but current anti-angiogenic medicines are ineffective due to compensatory molecular mechanisms. The development of gene-editing technology like CRISPR/Cas9 provides new possibilities for cancer therapy by dissecting carcinogenesis pathways, identifying new biological targets, and potentially arming cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Zhibao Wang, Bo Cao, Peng Ji, Fan Yao
Summary: Propofol inhibits tubular structure formation and various biological functions of tumor-associated endothelial cells, including migration, adhesion, proliferation, and survival, by suppressing the expression and secretion of multiple pro-angiogenic factors and specific signaling pathways. These findings provide preclinical evidence for the anti-cancer properties of propofol and its potential mechanisms in inhibiting tumor growth and metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Computer Science, Artificial Intelligence
Edson Damasceno Carvalho, Otilio Paulo da Silva Neto, Mano Joseph Mathew, Antonio Oseas de Carvalho Filho
Summary: Predicting the response of breast tumors to treatment is crucial for patients undergoing neoadjuvant chemotherapy. This study presents a new methodology that effectively predicts tumor response using dynamic contrast magnetic resonance imaging (DCE-MRI) and achieved high accuracy in various steps such as tumor segmentation and classification of malignancy. The proposed methodology proves to be efficient and can be integrated into a support system for breast cancer treatment.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Christian Osterburg, Volker Doetsch
Summary: The p53 protein family is highly studied and has a high similarity between crucial domains of p53, p63 and p73. However, they have different roles in tumor suppression, quality control, and development. This review focuses on the structure, organization, and evolutionary origin of p63 and p73, as well as their interactions and isoforms.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Yu-Shan Huang, Jann-Tay Wang, Hui-Ming Tai, Pai-Chun Chang, Hsin-Chang Huang, Pan-Chyr Yang
Summary: This study investigated the activity of metal nanoparticles against respiratory pathogens, including multidrug-resistant organisms (MDROs). The results showed that metal nanoparticles exhibited good in vitro antibacterial activity against Gram-negative bacteria. They may be suitable for use as environmental disinfectants or inhaled agents to inhibit the growth of MDROs in the lower respiratory tract of patients with chronic lung diseases.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Oncology
Li-Hsin Chien, Tzu-Yu Chen, Chung-Hsing Chen, Kuan-Yu Chen, Chin-Fu Hsiao, Gee-Chen Chang, Ying-Huang Tsai, Wu-Chou Su, Ming-Shyan Huang, Yuh-Min Chen, Chih-Yi Chen, Sheng-Kai Liang, Chung-Yu Chen, Chih-Liang Wang, Hsiao-Han Hung, Hsin-Fang Jiang, Jia-Wei Hu, Nathaniel Rothman, Qing Lan, Tsang-Wu Liu, Chien-Jen Chen, Pan-Chyr Yang, I-Shou Chang, Chao A. Hsiung
Summary: This study proposes methods for adapting risk models for populations without prospective cohorts, using the example of adapting a lung cancer risk model in Taiwan. The adapted models show high performance in calibration and clinical usefulness.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Editorial Material
Medicine, Research & Experimental
Kuo-Yen Huang, Ming-Shiu Lin, Pan-Chyr Yang
Summary: There is an unmet clinical need to end the COVID-19 pandemic. The SARS-CoV-2 has continued to evolve, posing a challenge to vaccine efficacy and neutralizing antibody therapies. The Omicron variants are driving the fifth wave of the pandemic due to their ability to evade prior immunity and resist therapeutic antibodies. A recent study shows that engineered decoy ACE2 can reduce lung injury and improve survival in transgenic mice infected with a lethal dose of SARS-CoV-2, potentially targeting the Omicron variant.
EMBO MOLECULAR MEDICINE
(2022)
Article
Oncology
Ching-Yao Yang, Yen -Ting Lin, Li-Ju Lin, Ya-Hsuan Chang, Hsuan-Yu Chen, Yi -Pin Wang, Jin -Yuan Shih, Chong-Jen Yu, Pan-Chyr Yang
Summary: Taiwan implemented several health policies including smoking cessation, precision therapy, and LDCT screening to combat lung cancer. The nationwide cancer registry data showed that although lung cancer incidence continued to rise, the mortality rate decreased over time. The analysis of patient data from National Taiwan University Hospital revealed a significant improvement in 5-year survival, particularly in late-stage lung cancer, suggesting the importance of early detection.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Emily Pei-Ying Lin, Chih-Yuan Hsu, Jeng-Fong Chiou, Lynne Berry, Leora Horn, Paul Bunn, James Chih-Hsin Yang, Pan-Chyr Yang, Alex A. Adjei, Yu Shyr
Summary: This study utilizes meta-analysis to demonstrate that there is a roughly 10% increase in long-term survival probability among ICI long-term survivors in PD-L1 positive subpopulations across ICI treatment lines. Additionally, the ST-HR consistently performs worse than the Cox HR. Neither the LT-DP nor the ST-HR achieved statistical significance for patients with PD-L1 less than 1%. This analysis provides greater insight into the treatment effect of ICI in published trials.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
S-Ja Tseng, Ivan M. Kempson, Zi-Xian Liao, Yi-Cheng Ho, Pan-Chyr Yang
Summary: Resistance to approved targeted therapies in non-small cell lung cancer (NSCLC) is a challenge, and oncolytic virotherapy has potential but faces systemic administration and viral delivery issues. This study designs an acid-degradable nanoparticle that releases virus using lactate secreted by tumors, offering a potential avenue for NSCLC treatment.
Article
Oncology
Tetsuya Mitsudomi, Daniel Tan, James Chih-Hsin Yang, Myung-Ju Ahn, Ullas Batra, Byoung-Chul Cho, Gerardo Cornelio, Tony Lim, Tony Mok, Kumar Prabhash, Thanyanan Reungwetwattana, Sheng-Xiang Ren, Navneet Singh, Shinichi Toyooka, Yi-Long Wu, Pan-Chyr Yang, Yasushi Yatabe
Summary: This study provides consensus recommendations for biomarker testing in Asian patients with non-small cell lung cancer. It highlights the importance of analyzing actionable genetic alterations in EGFR, ALK, ROS1, and others, including uncommon EGFR mutations. The role of liquid biopsy in assessing tumor biomarkers is also discussed.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Keng-Mao Liao, Chih-Jung Chen, Wei-Jia Luo, Chen-Wei Hsu, Sung-Liang Yu, Pan-Chyr Yang, Kang-Yi Su
Summary: With an aging population and the numerous health impacts associated with old age, there is a growing need to find effective anti-aging drugs. In this study, diphenyleneiodonium (DPI) was identified as a potential anti-aging drug that promotes mitochondrial fission. DPI was found to reduce senescence-associated beta-galactosidase positive cells and increase proliferating cells. It also downregulated cell cycle arrest genes and SASP factors. DPI treatment in mice showed reduced senescence markers and improved physical impairments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Tong-Hong Wang, Kuo-Yen Huang, Chin-Chuan Chen, Ya-Hsuan Chang, Hsuan-Yu Chen, Chuen Hsueh, Yi-Tsen Liu, Shuenn-Chen Yang, Pan-Chyr Yang, Chi-Yuan Chen
Summary: This study investigated the molecular mechanisms of PM2.5 exposure on lung cancer progression. Short-term exposure to PM2.5 activated the EGFR pathway in lung cancer cells, while long-term exposure persistently promoted EGFR activation, cell proliferation, anchorage-independent growth, and tumor growth in a xenograft mouse model. PM2.5 activated AhR to translocate into the nucleus and promoted EGFR activation. AhR further interacted with the promoter of TMPRSS2, thereby upregulating TMPRSS2 and IL18 expression to promote cancer progression. Depletion of TMPRSS2 suppressed anchorage-independent growth and xenograft tumor growth. TMPRSS2 expression correlated with nuclear AhR expression and cancer stage in lung cancer patient tissue.
EMBO MOLECULAR MEDICINE
(2023)
Editorial Material
Oncology
Chao-Hua Chiu, Pan-Chyr Yang
JOURNAL OF THORACIC ONCOLOGY
(2023)
Letter
Oncology
Ching-Yao Yang, Yen-Ting Lin, Li-Ju Lin, Pan-Chyr Yang
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M. Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A. Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y. Y. Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E. Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H. Hosgood, Hideo Kunitoh, Harsh Patel, Shun-ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J. Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G. Schwartz, Richard Houlston, Margaret R. Spitz, Ivan P. Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, Bu-Tian Ji, H-Erich Wichmann, David C. Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I. Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C. H. Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K. C. Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A. Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L. Stevens, Joseph F. Fraumeni, Nilanjan Chatterjee, Olga Y. Gorlova, Chao Agnes Hsiung, Christopher I. Amos, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan
Summary: This study identified 12 novel susceptibility variants for lung adenocarcinoma and a total of 28 loci associated with the disease in East Asian populations. Additionally, new candidate genes were discovered, contributing to the understanding of the disease etiology. These findings have important implications for the research and translational applications of lung adenocarcinoma in individuals from East Asian populations.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Chia-Yi Lin, Kuo-Yen Huang, Shih-Han Kao, Ming-Shiu Lin, Chih-Chien Lin, Shuenn-Chen Yang, Wei-Chia Chung, Ya-Hsuan Chang, Rong-Jie Chein, Pan-Chyr Yang
Summary: In this study, a small molecule drug called PIK-93 was discovered to modulate the tumor microenvironment by reducing PD-L1 levels and enhancing the cytotoxicity of M1 macrophages. Combined with anti-PD-L1 antibodies, PIK-93 treatment enhanced T cell activation, inhibited tumor growth, and increased the recruitment of tumor-infiltrating lymphocytes.
Article
Biology
Jung-Hsuan Chang, Chia-Hua Chou, Jui-Ching Wu, Keng-Mao Liao, Wei-Jia Luo, Wei-Lun Hsu, Xuan-Ren Chen, Sung-Liang Yu, Szu-Hua Pan, Pan-Chyr Yang, Kang-Yi Su
Summary: Mice deficient in LCRMP-1 show reduced fertility and perturbed F-actin cytoskeleton dynamics via the PI3K-Akt-mTOR axis. LCRMP-1 is abundantly expressed in the testis and plays a crucial role in spermatogenesis. LCRMP-1 deficiency causes disorganized F-actin due to unbalanced signaling of F-actin dynamics through upregulated PI3K-Akt-mTOR signaling, leading to aberrant spermiation and reduced fertility.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
David Chi-Leung Lam, Chong-Kin Liam, Sita Andarini, Samina Park, Daniel S. W. Tan, Navneet Singh, Seung Hun Jang, Varut Vardhanabhuti, Antonio B. Ramos, Tomio Nakayama, Nguyen Viet Nhung, Kazuto Ashizawa, Yeun-Chung Chang, Jamsak Tscheikuna, Cong Cung Van, Wai Yee Chan, Yeur-Hur Lai, Pan-Chyr Yang
Summary: The incidence and mortality of lung cancer are highest in Asia compared to Europe and USA. In some areas in Asia, there is limited availability of robust diagnostic tools and treatment modalities, making it necessary to have a more specific approach for screening and early detection of lung cancer.
JOURNAL OF THORACIC ONCOLOGY
(2023)