Article
Biochemistry & Molecular Biology
Chen-Lin Yu, Meng-Shih Weng, Wei-Cheng Chen, Kai-Ting Chien, Chih-Wen Chi, Ching-Hu Chung, Chia-Wen Huang, Po-Chuan Wang, Chien-Chih Chen, An-Chi Tsai, Shih-Chia Liu, Shih-Wei Wang
Summary: Moscatilin inhibits the metastatic behavior of HCC cells without cytotoxicity, potentially through the Akt/NF-kappa B signaling pathway to impede HCC invasion and uPA expression. It may serve as a potential anti-metastatic agent against human HCC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Victor M. Schuettfort, Benjamin Pradere, David D'Andrea, Nico C. Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I. Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Comperat, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma levels of uPA, SuPAR, and PAI-one were confirmed to be associated with aggressive disease features and worse survival outcomes in patients treated with RC for UCB. These biomarkers have the potential to identify patients who may benefit from intensified/multimodal therapy and improve the discriminatory power of predictive/prognostic models.
JOURNAL OF UROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Manuel Yepes, Yena Woo, Cynthia Martin-Jimenez
Summary: The neurovascular unit is a complex structure involving various cells and components that are essential for maintaining normal neuronal function. Plasminogen activators play a crucial role in regulating the function of the neurovascular unit, with dysfunction leading to neurodegenerative disorders. Research on the expression and function of tissue-type plasminogen activator and urokinase-type plasminogen activator in the neurovascular unit has provided valuable insights into neurovascular and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dhiraj Kumar Sah, Pham Ngoc Khoi, Shinan Li, Archana Arjunan, Jae-Uk Jeong, Young Do Jung
Summary: EGCG can inhibit the invasion ability of bladder cancer cells induced by IL-1β by suppressing the expression of uPAR through the inhibition of ERK1/2, JNK, AP-1, and NF-κB activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Koji Sugioka, Teruo Nishida, Aya Kodama-Takahashi, Junko Murakami, Fukutaro Mano, Kiyotaka Okada, Masahiko Fukuda, Shunji Kusaka
Summary: Corneal fibroblasts are regulated by collagen, and the targeting of Endo180 and uPA receptor may play a role in the regulation of alpha-SMA expression in a manner dependent on TGF-beta signaling. uPA deficiency may promote the interaction between collagen and Endo180 and increase alpha-SMA expression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Julia Elrod, Annika Heuer, Jasmin Knopf, Janina Schoen, Lavinia Schoenfeld, Magdalena Trochimiuk, Carolin Stiel, Birgit Appl, Laia Pagerols Raluy, Ceren Saygi, Leticija Zlatar, Sami Hosari, Dmytro Royzman, Thomas H. Winkler, Guenter Lochnit, Moritz Leppkes, Robert Gruetzmann, Georg Schett, Christian Tomuschat, Konrad Reinshagen, Martin Herrmann, Tobias A. Fuchs, Michael Boettcher
Summary: Peritoneal adhesions, commonly occurring conditions causing intestinal obstruction and pelvic pain, are poorly understood. However, DNases have been found to significantly reduce the formation of adhesions in experimental models.
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chung-Ze Wu, Li-Chien Chang, Chao-Wen Cheng, Te-Chao Fang, Yuh-Feng Lin, Dee Pei, Jin-Shuen Chen
Summary: The study investigated the relationship between urokinase plasminogen activator (uPA), metabolic disorders, glomerular filtration rate, and adipose tissues using obese mouse models. Results showed that triglyceride levels, insulin resistance, and body weight increased with duration on a high fat diet (HFD), while the expression of uPA decreased in brown adipose tissue (BAT) in obese mice fed a HFD. These findings suggest a potential association between BAT fibrosis and dysfunction in obese models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ashna A. Kumar, Benjamin J. Buckley, Marie Ranson
Summary: This review provides an overview of the role of the urokinase plasminogen activation system (uPAS) in pancreatic cancer, with a focus on pancreatic ductal adenocarcinoma (PDAC), and summarizes the substantial evidence supporting the role of uPAS components in this disease. The review further outlines the potential clinical utility of uPAS components as diagnostic and prognostic biomarkers for PDAC, as well as the rationale for developing novel uPAS-targeted therapeutics.
Review
Biochemistry & Molecular Biology
Paola Manzo, Valentina Giudice, Filomena Napolitano, Danilo De Novellis, Bianca Serio, Paolo Moscato, Nunzia Montuori, Carmine Selleri
Summary: The microenvironment is crucial for multiple myeloma development and progression. Macrophages and the urokinase plasminogen activator receptor (uPAR) system play important roles in these processes. Inhibitors of uPAR have shown potential therapeutic effects in primary multiple myeloma cells, reducing interleukein-6 and DKK-1 levels in culture medium. However, further studies are needed to validate these preliminary results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Torry A. Tucker, Steven Idell
Summary: This review discusses the fibrinolytic pathway, how local derangements of fibrinolysis promote extravascular fibrin deposition, and how pleural mesothelial cells contribute to lung scarring. It also explores the diagnostic value of soluble uPAR in grading pleural effusions, and the clinical importance of single-chain urokinase plasminogen activator (uPA) for treating loculated pleural collections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Review
Cell Biology
Steven L. Gonias
Summary: Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are serine proteases that play a crucial role in fibrinolysis in mammalian systems. Cells have evolved receptor systems to detect and respond to tPA and uPA, impacting various aspects of cell physiology. This review highlights the structure and function of plasminogen activator receptor assemblies and their role in regulating innate immunity and inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Immunology
Yu-Wen Cheng, Ze-Bei Zhang, Bei-Di Lan, Jing-Rong Lin, Xiao-Hui Chen, Ling-Ran Kong, Lian Xu, Cheng -Chao Ruan, Ping-Jin Gao
Summary: Obesity-induced adipose tissue-derived factors play a key role in cardiac damage, with the newly identified adipokine PDGF-D potentially regulating cardiac remodeling in obese mice. The study demonstrates that uPA activates PDGF-D and accelerates AngII-induced cardiac remodeling in obese mice by a new interaction pattern between macrophage and adipocyte.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Article
Orthopedics
Hiromi Sasaki, Satoshi Nagano, Hirofumi Shimada, Shunsuke Nakamura, Takao Setoguchi, Setsuro Komiya
JOURNAL OF ORTHOPAEDIC SCIENCE
(2018)
Article
Oncology
Hiromi Sasaki, Satoshi Nagano, Masahiro Yokouchi, Takao Setoguchi, Hirofumi Shimada, Takuya Yamamoto, Yasuhiro Ishidou, Setsuro Komiya
Article
Surgery
Costansia Bureta, Hiroyuki Tominaga, Takuya Yamamoto, Takao Setoguchi, Hideki Kawamura, Satoshi Nagano, Ichiro Kawamura, Masahiko Abematsu, Hironori Kakoi, Yasuhiro Ishidou, Setsuro Komiya
Article
Nutrition & Dietetics
Hiroto Tokumoto, Hiroyuki Tominaga, Yoshiya Arishima, Go Jokoji, Masaki Akimoto, Hideo Ohtsubo, Eiji Taketomi, Nobuhiko Sunahara, Satoshi Nagano, Yasuhiro Ishidou, Setsuro Komiya, Takao Setoguchi
Article
Nutrition & Dietetics
Hiromi Sasaki, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi, Takao Setoguchi
Article
Endocrinology & Metabolism
Yuhei Yahiro, Shingo Maeda, Naohiro Shinohara, Go Jokoji, Daisuke Sakuma, Takao Setoguchi, Yasuhiro Ishidou, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi
JOURNAL OF BONE AND MINERAL METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Yoshinobu Saitoh, Costansia Bureta, Hiromi Sasaki, Satoshi Nagano, Shingo Maeda, Tatsuhiko Furukawa, Noboru Taniguchi, Takao Setoguchi
MOLECULAR CARCINOGENESIS
(2019)
Article
Nutrition & Dietetics
Hiromi Sasaki, Satoshi Nagano, Noboru Taniguchi, Takao Setoguchi
Article
Oncology
Costansia Bureta, Yoshinobu Saitoh, Hiroto Tokumoto, Hiromi Sasaki, Shingo Maeda, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi, Takao Setoguchi
Article
Oncology
Takayuki Nakashima, Satoshi Nagano, Takao Setoguchi, Hiromi Sasaki, Yoshinobu Saitoh, Shingo Maeda, Setsuro Komiya, Noboru Taniguchi
Article
Orthopedics
Setsuro Komiya, Satoshi Nagano, Takao Setoguchi
JOURNAL OF ORTHOPAEDIC SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Hiroto Tokumoto, Takao Setoguchi, Yoshinobu Saitoh, Hiromi Sasaki, Satoshi Nagano, Shingo Maeda, Akihide Tanimoto, Noboru Taniguchi
MOLECULAR CARCINOGENESIS
(2019)
Article
Neurosciences
Costansia Bureta, Takao Setoguchi, Yoshinobu Saitoh, Hiroyuki Tominaga, Shingo Maeda, Satoshi Nagano, Setsuro Komiya, Takuya Yamamoto, Noboru Taniguchi
Article
Environmental Sciences
Hyuma Makizako, Ryoji Kiyama, Daisaku Nishimoto, Ikuko Nishio, Tomomi Masumitsu, Yuriko Ikeda, Misako Hisamatsu, Sachiko Shimizu, Masami Mizuno, Mikiyo Wakamatsu, Naomi Inoue, Takayuki Tabira, Tadasu Ohshige, Ayako Yamashita, Satoshi Nagano
Summary: Regular exercise has been found to be significantly correlated with improved self-rated health and sleep quality in middle-aged adults during the COVID-19 pandemic, while no significant correlation was observed in young and older adults. Promoting regular exercise among middle-aged individuals during the pandemic may lead to better overall health outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Hiroyuki Tominaga, Manei Oku, Yoshiya Arishima, Toru Ikeda, Yasuhiro Ishidou, Satoshi Nagano, Masato Minami, Akio Ido, Setsuro Komiya, Takao Setoguchi
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
(2018)