Article
Immunology
Sophia Giang, David A. Horwitz, Sean Bickerton, Antonio La Cava
Summary: This study introduces a method to produce acellular tolerogenic aAPCs using PLGA nanoparticles, which can induce human T cells to become functional Tregs and modulate systemic autoimmunity. It highlights the potential of using PLGA NPs as a targeted approach to repair IL-2 and/or TGF-beta defects in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Juliane Schuhmacher, Leon Kleemann, Jennifer Rebecca Richardson, Elisa Rusch, Hans-Georg Rammensee, Cecile Gouttefangeas
Summary: Elongated peptides (EPs) are widely used for screening immune cell responses, and this study presents an in vitro protocol for their amplification and functional analysis. It was found that the elongation site of EPs affected the response of CD8(+) T cells, while CD4(+) T cell responses were completely lost in some tests. However, the use of short-term amplification and a TLR3 agonist significantly improved the detection of both CD8(+) and CD4(+) T cell reactivities.
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Immunology
Ezgi Sengun, Tim G. A. M. Wolfs, Valery L. E. van Bruggen, Bram van Cranenbroek, Elles R. Simonetti, Daan Ophelders, Marien I. de Jonge, Irma Joosten, Renate G. van der Molen
Summary: Inflammation is a physiological state where immune cells respond to harmful insults. Human mesenchymal stem cells (hMSC) have immunomodulatory effects and regenerative capacity, making them a promising therapeutic option for inflammation. However, the regulatory effects of hMSC on T cells, particularly in CD4(+) T cell memory formation and responsiveness, are not fully understood. Our study investigated the effects of umbilical cord mesenchymal stem cells (UC-MSC) on CD4(+) T cells and found that cell-cell contact and paracrine factors are necessary for the immunomodulatory effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elizabeth Robins, Ming Zheng, Qingshan Ni, Siqi Liu, Chen Liang, Baojun Zhang, Jian Guo, Yuan Zhuang, You-Wen He, Ping Zhu, Ying Wan, Qi-Jing Li
Summary: Recent research has revealed that CD4(+) and CD8(+) T cells in adaptive immunity can exhibit significant lineage plasticity, even undergoing fundamental lineage reprogramming. This shift in functional potential may suggest a new direction for HIV vaccine design.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Beatriz Coutinho de Oliveira, Ailton Alvaro da Silva, Marton Kaique de Andrade Cavalcante, Maria Edileuza Felinto de Brito, Maria Carolina Accioly Brelaz de Castro, Vanessa Lucilia Silveira de Medeiros, Rafael de Freitas e Silva, Valeria Rego Alves Pereira
Summary: Cutaneous Leishmaniasis (CL) is a skin ulcer disease caused by protozoans, and there is no vaccine available. Previous research identified T cell epitopes of Leishmania braziliensis and tested their ability to rescue memory T cells during natural infection. The study found increased frequencies of TCM and TEM, especially in the CD8 compartment, during CL. These results suggest a potentially immunogenic profile of the peptides and support the development of anti-Leishmania formulations.
Article
Immunology
Nianbin Song, Robin A. Welsh, Scheherazade Sadegh-Nasseri
Summary: The absence of HLA-DO protein alters the presentation of foreign antigens and impacts the development of memory cells. This finding provides new insights for vaccine design and improves immune memory responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Shi Zou, Yuting Tan, Yanni Xiang, Yang Liu, Qi Zhu, Songjie Wu, Wei Guo, Mingqi Luo, Ling Shen, Ke Liang
Summary: This study found a significant increase in CD4 and CD8 double-positive (DP) T cells in patients with HIV/TB coinfection. Additionally, these DP T cells also expressed more cytotoxic markers. This suggests that DP T cells may play an important immune role in HIV/TB infection.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cell Biology
Menglu Gao, Yili Liu, Mingquan Guo, Qianying Wang, Yan Wang, Jian Fan, Yinzhong Shen, Junjie Hou, Yanmin Wan, Zhaoqin Zhu
Summary: The study found that frequencies of lymphocytes and T cells decreased significantly in COVID-19 patients, while the CD4(+)/CD8(+)T cell ratios increased significantly in patients over 45 years old. Regulatory CD4(+) and CD8(+) T cells may play distinct roles in the pathogenesis of COVID-19, and NK cells might contribute to the lymphopenia associated with COVID-19.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Leila Khajavi, Xuan-Hung Nguyen, Clemence Queriault, Marianne Chabod, Lucie Barateau, Yves Dauvilliers, Matthias Zytnicki, Roland Liblau
Summary: This study identified differentially expressed genes in T-cell subsets between narcolepsy patients and healthy controls through RNA sequencing analysis, and found that these genes are involved in processes such as immune synapse formation, TCR activation, and inflammatory response. The results showed an inflammatory transcriptomic profile in naive CD4 and CD8 T-cell subsets, possibly indicating their involvement in the development or progression of narcolepsy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hui Jin, Monowar Aziz, Atsushi Murao, Molly Kobritz, Andrew J. Shih, Robert P. Adelson, Max Brenner, Ping Wang
Summary: Extracellular cold-inducible RNA-binding protein (eCIRP) is a key factor in the severity and mortality of sepsis, which induces the formation of antigen-presenting aged neutrophils (APANs) through CD4+ T cell activation, Th1 polarization, and IFN-gamma-mediated hyper-NETosis. APANs exacerbate acute lung injury (ALI) and worsen the survival of septic animals. These findings highlight the role of eCIRP and APANs in sepsis pathogenesis and potential therapeutic targets.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Neurosciences
Tugberk Kaya, Nicola Mattugini, Lu Liu, Hao Ji, Ludovico Cantuti-Castelvetri, Jianping Wu, Martina Schifferer, Janos Groh, Rudolf Martini, Simon Besson-Girard, Seiji Kaji, Arthur Liesz, Ozgun Gokce, Mikael Simons
Summary: This study identified age-related alterations of oligodendrocyte cell state in aging murine white matter and found interferon (IFN)-responsive oligodendrocytes in proximity to CD8(+) T cells. Functional lymphocytes were shown to influence the number of IFN-responsive oligodendrocytes, with T-cell checkpoint inhibition exacerbating the aging response.
NATURE NEUROSCIENCE
(2022)
Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Lene S. Hoydahl, Terje Frigstad, Ingunn B. Rasmussen, Inger Oynebraten, Karoline W. Schjetne, Jan Terje Andersen, Terje E. Michaelsen, Elin Lunde, Bjarne Bogen, Inger Sandlie
Summary: Different antibody-antigen fusion modes have varying effects on inducing T-cell responses, with Troybody being more effective than fusion of antigen to the C-terminus of antibodies. This approach enhances activation of CD4 and CD8 peptide-specific T cells.
